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1
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44849141907
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Regulation of the high affinity IgE receptor (Fc epsilonRI) in human neutrophils: role of seasonal allergen exposure and Th-2 cytokines
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Alphonse M.P., Saffar A.S., Shan L., HayGlass K.T., Simons F.E., and Gounni A.S. Regulation of the high affinity IgE receptor (Fc epsilonRI) in human neutrophils: role of seasonal allergen exposure and Th-2 cytokines. PLoS ONE 3 (2008) e1921
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Human airway smooth muscle cells express the high affinity receptor for IgE (Fc epsilon RI): a critical role of Fc epsilon RI in human airway smooth muscle cell function
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Gounni A.S., Wellemans V., Yang J., Bellesort F., Kassiri K., Gangloff S., Guenounou M., Halayko A.J., Hamid Q., and Lamkhioued B. Human airway smooth muscle cells express the high affinity receptor for IgE (Fc epsilon RI): a critical role of Fc epsilon RI in human airway smooth muscle cell function. J Immunol 175 (2005) 2613-2621
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4
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36348954295
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Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?
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A surprising observation that FcεRI can be found in neural tissue cells.
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Ganguly S., Grodzki C., Sugden D., Moller M., Odom S., Gaildrat P., Gery I., Siraganian R.P., Rivera J., and Klein D.C. Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?. J Biol Chem 282 (2007) 32758-32764. A surprising observation that FcεRI can be found in neural tissue cells.
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5
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0034744221
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Expression and modulation of FcεRIα and FcεRIβ in human blood basophils
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Saini S., Richardson J.J., Wofsy C., Lavens-Phillips, Bochner B., and MacGlashan Jr. D.W. Expression and modulation of FcεRIα and FcεRIβ in human blood basophils. J All Clin Immunol 107 (2001) 832-841
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Saini, S.1
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6
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40149110023
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Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI
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Hartman M.L., Lin S.Y., Jouvin M.H., and Kinet J.P. Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI. Mol Immunol 45 (2008) 2307-2311
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Hartman, M.L.1
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7
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34848923612
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Endocytosis, re-cycling and degradation of unoccupied FcεRI in human basophils
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Study showing the life-cycle behavior of human FcεRI in peripheral blood basophils. This study demonstrates that the unoccupied receptor is lost by endocytosis and that IL-3 controls recycling of receptor.
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MacGlashan Jr. D.W. Endocytosis, re-cycling and degradation of unoccupied FcεRI in human basophils. J Leukoc Biol 82 (2007) 1003-1010. Study showing the life-cycle behavior of human FcεRI in peripheral blood basophils. This study demonstrates that the unoccupied receptor is lost by endocytosis and that IL-3 controls recycling of receptor.
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MacGlashan Jr., D.W.1
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8
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45749121689
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IL-10 suppresses mast cell IgE receptor expression and signaling in vitro and in vivo
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Kennedy Norton S., Barnstein B., Brenzovich J., Bailey D.P., Kashyap M., Speiran K., Ford J., Conrad D., Watowich S., Moralle M.R., et al. IL-10 suppresses mast cell IgE receptor expression and signaling in vitro and in vivo. J Immunol 180 (2008) 2848-2854
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Kennedy Norton, S.1
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9
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42149162890
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Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling
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A demonstration that expression of FcεRI in murine mast cells can be regulated by cell-cell contact with a murine T cell.
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Kashyap M., Thornton A.M., Norton S.K., Barnstein B., Macey M., Brenzovich J., Shevach E., Leonard W.J., and Ryan J.J. Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling. J Immunol 180 (2008) 2039-2043. A demonstration that expression of FcεRI in murine mast cells can be regulated by cell-cell contact with a murine T cell.
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Kashyap, M.1
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10
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Wang Q.H., Nishiyama C., Nakano N., Shimokawa N., Hara M., Kanada S., Ogawa H., and Okumura K. Suppressive effect of Elf-1 on FcepsilonRI alpha-chain expression in primary mast cells. Immunogenetics 60 (2008) 557-563
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Wang, Q.H.1
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p28, a novel IgE receptor-associated protein, is a sensor of receptor occupation by its ligand in mast cells
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Charles N., Monteiro R.C., and Benhamou M. p28, a novel IgE receptor-associated protein, is a sensor of receptor occupation by its ligand in mast cells. J Biol Chem 279 (2004) 12312-12318
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Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases
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Kitaura J., Eto K., Kinoshita T., Kawakami Y., Leitges M., Lowell C.A., and Kawakami T. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol 174 (2005) 4495-4504
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Kitaura, J.1
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13
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28444471199
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Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response
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Matsuda K., Piliponsky A.M., Iikura M., Nakae S., Wang E.W., Dutta S.M., Kawakami T., Tsai M., and Galli S.J. Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response. J Allergy Clin Immunol 116 (2005) 1357-1363
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48649092277
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Pivotal Advance: IgE accelerates in vitro development of mast cells and modifies their phenotype
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Kashiwakura J.I., Xiao W., Kitaura J., Kawakami Y., Maeda-Yamamoto M., Pfeiffer J.R., Wilson B.S., Blank U., and Kawakami T. Pivotal Advance: IgE accelerates in vitro development of mast cells and modifies their phenotype. J Leukoc Biol 84 (2008) 357-367
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15
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0023185832
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Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE
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MacDonald S.M., Lichtenstein L.M., Proud D., Plaut M., Naclerio R.M., MacGlashan Jr. D.W., and Kagey S.A. Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE. J Immunol 139 (1987) 506-512
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16
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Human IgE+ and IgE- are not equivalent to mouse highly cytokinergic IgE
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Xie L., Schroeder J.T., Langdon J.M., Sora-Scott R.S., Kawakami T., and MacDonald S.M. Human IgE+ and IgE- are not equivalent to mouse highly cytokinergic IgE. J Allergy Clin Immunol 121 (2008) 1027-1033
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Bivalent ligands with rigid double-stranded DNA spacers reveal structural constraints on signaling by Fc epsilon RI
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Paar J.M., Harris N.T., Holowka D., and Baird B. Bivalent ligands with rigid double-stranded DNA spacers reveal structural constraints on signaling by Fc epsilon RI. J Immunol 169 (2002) 856-864
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Kinetic proofreading in T-cell receptor signal transduction
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McKeithan, T.W.1
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20
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Death of a dogma or enforcing the artificial: monomeric IgE binding may initiate mast cell response by inducing its receptor aggregation
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A very useful set of calculations regarding the presence of spontaneous aggregates at high densities of FcεRI that may have application to the studies of monomeric IgE stimulating mast cells. It is notable, however, that this paper does not address the issue of aggregate lifetime.
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Schweitzer-Stenner R., and Pecht I. Death of a dogma or enforcing the artificial: monomeric IgE binding may initiate mast cell response by inducing its receptor aggregation. J Immunol 174 (2005) 4461-4464. A very useful set of calculations regarding the presence of spontaneous aggregates at high densities of FcεRI that may have application to the studies of monomeric IgE stimulating mast cells. It is notable, however, that this paper does not address the issue of aggregate lifetime.
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Schweitzer-Stenner, R.1
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0022615314
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Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links
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MacGlashan Jr. D.W., Peters S.P., Warner J., and Lichtenstein L.M. Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links. J Immunol 136 (1986) 2231-2239
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MacGlashan Jr., D.W.1
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0018743531
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Histamine release due to bivalent penicilloyl haptens: the relation of activation and desensitization of basophils to dynamic aspects of ligand binding to cell surface antibody
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Dembo M., Goldstein B., Sobotka A.K., and Lichtenstein L.M. Histamine release due to bivalent penicilloyl haptens: the relation of activation and desensitization of basophils to dynamic aspects of ligand binding to cell surface antibody. J Immunol 122 (1979) 518-528
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24
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0036347746
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Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
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Parravicini V., Gadina M., Kovarova M., Odom S., Gonzalez-Espinosa C., Furumoto Y., Saitoh S., Samelson L.E., O'Shea J.J., and Rivera J. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 3 (2002) 741-748
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Parravicini, V.1
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25
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34948882787
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The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn
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Following on the heals of studies implicating a second src-family kinase in FcεRI signaling, this study adds another layer of complexity into the very earliest steps of FcεRI signaling by proposing that a third src-family member is involved.
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Hong H., Kitaura J., Xiao W., Horejsi V., Ra C., Lowell C.A., Kawakami Y., and Kawakami T. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood 110 (2007) 2511-2519. Following on the heals of studies implicating a second src-family kinase in FcεRI signaling, this study adds another layer of complexity into the very earliest steps of FcεRI signaling by proposing that a third src-family member is involved.
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Hong, H.1
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26
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The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production
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Furumoto Y., Nunomura S., Terada T., Rivera J., and Ra C. The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. J Biol Chem 279 (2004) 49177-49187
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27
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26444527081
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Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE
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Nunomura S., Gon Y., Yoshimaru T., Suzuki Y., Nishimoto H., Kawakami T., and Ra C. Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. Int Immunol 17 (2005) 685-694
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Nunomura, S.1
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Nonspecific desensitization, functional memory and the characteristics of SHIP phosphorylation following IgE-mediated stimulation of human basophils
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MacGlashan Jr. D.W., and Vilarino N. Nonspecific desensitization, functional memory and the characteristics of SHIP phosphorylation following IgE-mediated stimulation of human basophils. J Immunol 177 (2006) 1040-1051
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J Immunol
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MacGlashan Jr., D.W.1
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Ishmael S., and MacGlashan Jr. D.W. Kinetics of Syk expression in human basophils differentiatling from CD34+ progenitors. FASEB J 22 (2008) 1071-1075
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MacGlashan Jr., D.W.2
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31
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33847281336
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Relationship between Syk and SHIP expression and secretion from human basophils in the general population
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This study provides important background on the expression levels of 6 critical signaling elements in peripheral blood basophils obtained from a general population sample. Notably, variance in the expression of syk accounts for a major portion of the variance in IgE-mediated histamine release in general population.
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MacGlashan Jr. D.W. Relationship between Syk and SHIP expression and secretion from human basophils in the general population. J Allergy Clin Immunol 119 (2007) 626-633. This study provides important background on the expression levels of 6 critical signaling elements in peripheral blood basophils obtained from a general population sample. Notably, variance in the expression of syk accounts for a major portion of the variance in IgE-mediated histamine release in general population.
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J Allergy Clin Immunol
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MacGlashan Jr., D.W.1
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Src homology 2 domain-containing inositol 5' phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils
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Vonakis B.M., Gibbons Jr. S., Sora R., Langdon J.M., and MacDonald S.M. Src homology 2 domain-containing inositol 5' phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils. J Allergy Clin Immunol 108 (2001) 822-831
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33
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33846796264
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Basophil FcepsilonRI histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria
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Vonakis B.M., Vasagar K., Gibbons Jr. S.P., Gober L., Sterba P.M., Chang H., and Saini S.S. Basophil FcepsilonRI histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria. J Allergy Clin Immunol 119 (2007) 441-448
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34
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Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation
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Gibbs B.F., Rathling A., Zillikens D., Huber M., and Haas H. Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation. J Allergy Clin Immunol 118 (2006) 1060-1067
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J Allergy Clin Immunol
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Gibbs, B.F.1
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35
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34250874425
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The inositol 5′-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production
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A great deal of attention has previously been focused on expression and activity of SHIP1 in mast cell function. This study explores the role of SHIP2, which is often present with SHIP1 in basophils or mast cells.
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Leung W.H., and Bolland S. The inositol 5′-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J Immunol 179 (2007) 95-102. A great deal of attention has previously been focused on expression and activity of SHIP1 in mast cell function. This study explores the role of SHIP2, which is often present with SHIP1 in basophils or mast cells.
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J Immunol
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Leung, W.H.1
Bolland, S.2
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36
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37349067978
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Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels
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An important demonstration of the criticality of the CRACM1 protein in the cytosolic calcium response in mast cells and therefore the ability of mast cells to mediate allergic inflammation.
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Vig M., DeHaven W.I., Bird G.S., Billingsley J.M., Wang H., Rao P.E., Hutchings A.B., Jouvin M.H., Putney J.W., and Kinet J.P. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol 9 (2008) 89-96. An important demonstration of the criticality of the CRACM1 protein in the cytosolic calcium response in mast cells and therefore the ability of mast cells to mediate allergic inflammation.
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Nat Immunol
, vol.9
, pp. 89-96
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Vig, M.1
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37
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37349073896
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Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
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An important demonstration of the criticality of both CRACM1 and STIM1 in mediating the cytocolic calcium response in mast cells.
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Baba Y., Nishida K., Fujii Y., Hirano T., Hikida M., and Kurosaki T. Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat Immunol 9 (2008) 81-88. An important demonstration of the criticality of both CRACM1 and STIM1 in mediating the cytocolic calcium response in mast cells.
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Nat Immunol
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Baba, Y.1
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38
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42149127676
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Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line
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