Unrelated Transplantation for Poor-Prognosis Adult Acute Lymphoblastic Leukemia: Long-Term Outcome Analysis and Study of the Impact of Hematopoietic Graft Source

Biology of Blood and Marrow Transplantation

Volumn 16, Issue 7, 2010, Pages 957-966

  Ferrá, Christelle ^a   Sanz, Jaime ^b   de la Cámara, Rafael ^c   Sanz, Guillermo ^b   Bermúdez, Arancha ^d   Valcárcel, David ^e   Rovira, Montserrat ^f   Serrano, David ^g   Caballero, Dolores ^h   Espigado, Ildefonso ⁱ   Morgades, Mireia ^a   Heras, Inmaculada ^j   Solano, Carlos ^k   Duarte, Rafael ^l   Barrenetxea, Cristina ^m   García Noblejas, Ana ^c   Díez Martin, José L ^g   Iriondo, Arturo ^d   Carreras, Enric ^f   Sierra, Jordi ^e   Sanz, Miguel Ángel ^b   Ribera, Josep Maria ^a   more..

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d Unidad de Alta Resolución Hospitalaría Hospital Marqués de Valdecilla Santander   (Spain)

^e HOSPITAL SANT PAU   (Spain)

^f HOSPITAL CLÍNIC   (Spain)

^g HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^h HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

ⁱ HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^j HOSPITAL MORALES MESEGUER   (Spain)

^k HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^l HOSPITAL DURAN I REYNALS   (Spain)

^m HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

more..

Author keywords

Adult acute lymphoblastic leukemia; Poor risk; Unrelated cord blood transplantation; Unrelated donor hematopoietic stem cell transplantation

Indexed keywords

CYCLOSPORIN A; METHOTREXATE; MYCOPHENOLIC ACID; PREDNISONE;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CANCER REGRESSION; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; CYTOGENETICS; DISEASE FREE SURVIVAL; FEMALE; GENE FREQUENCY; GENE REARRANGEMENT; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PROGNOSIS;

EID: 77953554452     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2010.02.003     Document Type: Article

References (51)

1. Bishop M.R., Logan B.R., Gandham S., et al. Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: a comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research. Bone Marrow Transplant 2007, 41:635-642.
2. Goldstone A.H., Richards S.M., Lazarus H.M., et al. In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional onsolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993). Blood 2008, 111:1827-1833.
3. Ljungman P., Urbano-Ispizua A., Cavazzana-Calvo M., et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe. Bone Marrow Transplant 2006, 37:439-449.
4. Thiebault A., Vernant J.P., Degos L., et al. Adult acute lymphocytic leukemia study testing chemotherapy, and autologous and allogeneic transplantation: follow-up reports of the French protocol LALA 87. Hematol Oncol Clin North Am 2000, 14:1353-1366.
5. Thomas X., Boiron J.M., Huguet F., et al. Outcome of treatment of adults with acute lymphoblastic leukemia: analysis of LAL-94 trial. J Clin Oncol 2004, 22:4075-4086.
6. Hallböök H., Hägglund H., Stockelberg D., et al. Autologous and allogeneic stem cell transplantation in adult ALL: the Swedish Adult ALL Group experience. Bone Marrow Transplant 2005, 35:1141-1148.
7. Marks D.I., Aversa F., Lazarus H.M. Alternative donor transplants for adult acute lymphoblastic leukaemia: a comparison of the three major options. Bone Marrow Transplant 2006, 38:467-475.
8. Bachanova V., Weisdorf D. Unrelated donor allogeneic transplantation for adult acute lymphoblastic leukaemia: a review. Bone Marrow Transplant 2008, 41:455-464.
9. Hoelzer D., Göckbuget N. New approaches in acute lymphoblastic leukemia in adults. Where do we go?. Semin Oncol 2000, 27:540-559.
10. Ribera J.M., Oriol A., Bethencourt C., et al. Comparison of intensive chemotherapy, allogeneic or autologous stem cell transplantation as post-remission treatment for adult patients with high-risk acute lymphoblastic leukaemia: results of the PETHEMA ALL-93 trial. Haematologica 2005, 90:1346-1356.
11. Cornelissen J.J., Carston M., Kollman C., et al. Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome. Blood 2001, 97:1572-1577.
12. Chim C.S., Lie A.K.W., Au W.Y., et al. Long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favourable outcome with BMT at first remission and HLA-matched related donor. Bone Marrow Transplant 2007, 40:339-347.
13. Kiehl M.G., Kraut L., Schwerdfeger R., et al. Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission. J Clin Oncol 2004, 22:2816-2825.
14. Fielding A.K., Rowe J.M., Richards S.M., et al. Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia confirms superiority of allogeneic transplant over chemotherapy in the pre-imatinib era: results from the international ALL trial MRC UKALLXII/ECOG2993. Blood 2009, 113:4489-4496.
15. Schoemans H., Theunissen K., Maertens J., et al. Adult umbilical cord blood transplantation: a comprehensive review. Bone Marrow Transplant 2006, 38:83-93.
16. Sanz G.F., Saavedra S., Planelles D., et al. Standarized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 2001, 98:2332-2338.
17. Rubinstein P., Carrier C., Scaradavou A., et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998, 339:1565-1577.
18. Rocha V., Labopin M., Sanz G., et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukaemia. N Eng J Med 2004, 351:2276-2285.
19. Laughlin M.J., Eapen M., Rubinstein P., et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukaemia. N Eng J Med 2004, 351:2265-2275.
20. Takahashi S., Iseki T., Ooi J., et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood 2004, 104:3813-3820.
21. Magro E., Regidor C., Cabrera R., et al. Early hematopoietic recovery after single unit unrelated cord blood transplantation in adults supported by co-infusion of mobilized stem cells from a third-party donor. Haematologica 2006, 91:640-648.
22. Kamani N., Spellman S., Hurley C.K., et al. State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplants. Biol Blood Marrow Transplant 2008, 14:1-6.
23. Atsuta Y., Suzuki R., Nagamura-Inoue T., et al. Disease-specific analyses of unrelated cord blood transplant compared with unrelated bone marrow transplant in adult patients with acute leukemia. Blood 2009, 113:1631-1638.
24. Ribera J.M., Oriol A., Morgades M., et al. Treatment of high-risk (HR) Philadelphia chromosome-negative (Ph-) adult acute lymphoblastic leukemia (ALL) according to classical risk factors and minimal residual disease (MRD): interim results of the PETHEMA ALL-AR-03 Trial. 48th Annual Meeting of the American Society of Hemaotology, Orlando, FL, December 9-12 [abstract 1872]. Blood 2006, 106:531a.
25. Ribera J.M., Oriol A., González M., et al. Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukaemia: final results of the CSTIBES02 trial. Haematologica 2010, 95:87-95.
26. Przepiorka D., Weisdorf D., Martin P., et al. Consensus conference on acute GVHD grading. Bone Marrow Transplant 1995, 15:825-828.
27. Sullivan K.M., Agura E., Anesetti C., et al. Chronic graft-versus-host disease and other late complications of bone marrow transplantation. Semin Hematol 1991, 28:250-259.
28. Atkinson K. Chronic graft-versus-host disease. Bone Marrow Transplant 1990, 5:69-82.
29. Kaplan E.L., Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
30. Gray R.J. A class of k-sample tests for comparing the cumulative incidence of a competiting risk. Ann Stat 1988, 16:1141-1154.
31. Barker J.N., Davies S.M., DeFor T., et al. Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood 2001, 97:2957-2961.
32. Eapen M., Rubinstein P., Zhang M.J., et al. Outcome of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 2007, 369:1947-1954.
33. Tomblyn M.B., Arora M., Baker S., et al. Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome. J Clin Oncol 2009, 27:3634-3641.
34. Garderet L., Labopin M., Gorin N.C., et al. Patients with acute lymphoblastic leukaemia allografted with a matched unrelated donor may have a lower survival with a peripheral blood stem cell graft compared to bone marrow. Bone Marrow Transplant 2003, 31:23-29.
35. Weisdorf D., Spellman S., Haagenson M., et al. Classification of HLA-matching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival. Biol Blood Marrow Transplant 2008, 14:748-758.
36. Filipovich A.H., Weisdorf D., Pavletic S., et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease, I: Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant 2005, 11:945-955.
37. Barker J.N. Umbilical cord blood (UCB) transplantation: an alternative to the use of unrelated volunteer donors?. Hematol Am Soc Hematol Educ Program 2007, 2007:55-61.
38. Parody R., Martino R., Rovira M., et al. Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation. Biol Blood Marrow Transplant 2006, 12:734-748.
39. Dahlke J., Kröger N., Zabelina T., et al. Comparable results in patients with acute lymphoblastic leukemia after related and unrelated stem cell transplantation. Bone Marrow Transplant 2006, 37:155-163.
40. Doney K., Hägglund H., Leisenring W., et al. Predictive factors for outcome of allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia. Biol Blood Marrow Transplant 2003, 9:472-481.
41. Lee S., Cho B.S., Kim S.Y., et al. Allogeneic stem cell transplantation in first complete remission enhances graft-versus leukemia effect in adults with acute lymphoblastic leukemia: antileukemic activity of chronic graft-versus host disease. Biol Blood Marrow Transplant 2007, 13:1083-1094.
42. Zikos P., Van Lint M.T., Lamparelli T., et al. Allogeneic hemopoietic stem cell transplantation for patients with high-risk acute lymphoblastic leukemia: favorable impact of chronic graft-versus-host disease on survival and relapse. Haematologica 1998, 83:896-903.
43. Nordlander A., Mattsson J., Ringdén O., et al. Graft-versus-host disease is associated with a lower relapse incidence after hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia. Biol Blood Marrow Transplant 2004, 10. 195-20.
44. Stirewalt D.L., Guthrie K.A., Beppu L., et al. Predictors of relapse and overall survival in Philadelphia chromosome-positive acute lymphoblastic leukemia after transplantation. Biol Blood Marrow Transplant 2003, 9:206-212.
45. Grigg A.P., Szer J., Beresford J., et al. Factors affecting the outcome of allogeneic bone marrow transplantation for adult patients with refractory or relapsed acute leukaemia. Br J Haematol 1999, 107:409-418.
46. Kumar P., Defor T.E., Brunstein C., et al. Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source in survival. Biol Blood Marrow Transplant 2008, 14:1394-1400.
47. Granados E., De La Camara R., Madero L., et al. Hematopoietic cell transplantation in acute lymphoblastic leukaemia: better long-term event-free survival with conditioning regimens containing total body irradiation. Hematologica 2000, 85:1060-1067.
48. Verneris M.R., Brunstein C.G., Barker J., et al. Relapse risk after umbilical cord blood transplantation: enhanced graft-versusleukemia effect in recipients of 2 units. Blood 2009, 114:4293-4299.
49. Frassoni F., Gualandi F., Podestà M., et al. Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study. Lancet Oncol 2008, 9:831-839.
50. Brunstein C.G., Barker J.N., Weisdorf D.J., et al. Intra-BM injection to enhance engraftment after myeloablative umbilical cord blood transplantation with two partially HLA-matched units. Bone Marrow Transplant 2009, 43:935-940.
51. Flomenberg N., Baxter-Lowe L.A., Confer D., et al. Impact of HLA class I and II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C is associated with a strong adverse effect on transplantation outcome. Blood 2004, 104:1923-1930.