Central pontine and extrapontine myelinolysis despite careful correction of hyponatremia: Clinical and neuropathological findings of a case

Neurological Sciences

Volumn 31, Issue 2, 2010, Pages 227-230

  Pietrini, Vladimiro ^a   Mozzani, Flavio ^b   Crafa, Pellegrino ^a   Sivelli, Roberto ^a   Cademartiri, Filippo ^b   Crisi, Girolamo ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY HOSPITAL OF PARMA   (Italy)

Author keywords

Central pontine myelinolysis; Demyelination; Hyponatremia; MRI; Neuropathology

Indexed keywords

CANRENONE; CORTICOSTEROID; DIURETIC AGENT; FUROSEMIDE; HYDROCHLOROTHIAZIDE; IMMUNOGLOBULIN; METHYLPREDNISOLONE; SODIUM; SODIUM CHLORIDE; URIC ACID;

ADULT; ANOREXIA; ARTICLE; ASTHENIA; AUTOPSY; BASAL GANGLION; BREAST CANCER; CASE REPORT; CENTRAL PONTINE MYELINOLYSIS; DIFFERENTIAL DIAGNOSIS; DIFFUSION WEIGHTED IMAGING; DROWSINESS; DRUG MEGADOSE; DYSMETRIA; DYSPHAGIA; FEMALE; HUMAN; HUMAN TISSUE; HYPERTENSION; HYPONATREMIA; HYSTERECTOMY; INAPPROPRIATE VASOPRESSIN SECRETION; LEG EDEMA; LETHARGY; LOW DRUG DOSE; MASTECTOMY; NAUSEA; NEUROPATHOLOGY; PEMPHIGUS; QUADRIPLEGIA; SALPINGOOOPHORECTOMY; SODIUM BLOOD LEVEL; SODIUM URINE LEVEL; STOMACH PAIN; TREMOR; VOMITING;

ACUTE DISEASE; BRAIN; DIFFUSION MAGNETIC RESONANCE IMAGING; DISEASE PROGRESSION; FATAL OUTCOME; FEMALE; HUMANS; HYPONATREMIA; MACROPHAGES; MIDDLE AGED; MYELINOLYSIS, CENTRAL PONTINE; PULMONARY EMBOLISM; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 77953545622     PISSN: 15901874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10072-009-0173-0     Document Type: Article

References (15)

1. Brown WD (2000) Osmotic demyelination disorders: central pontine and extrapontine myelinolysis. Curr Opin Neurol 13(6):691-697
2. Martin RJ (2004) Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes. J Neurol Neurosurg Psychiatry 75(Suppl 3):iii22-iii28
3. Kleinschmidt-DeMasters BK, Rojiani AM, Filley CM (2006) Central and extrapontine myelinolysis: then...and now. J Neuropathol Exp Neurol 65(1):1-11
4. Mast H, Gordon PH, Mohr JP, Tatemichi TK (1995) Central pontine myelinolysis: clinical syndrome with normal serum sodium. Eur J Med Res 1(3):168-170
5. Sugimoto T, Murata T, Omori M, Wada Y (2003) Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. J Neurol Neurosurg Psychiatry 74(3):353-355
6. Michell AW, Burn DJ, Reading PJ (2003) Central pontine myelinolysis temporally related to hypophosphataemia. J Neurol Neurosurg Psychiatry 74(6):820
7. Omari A, Kormas N, Field M (2002) Delayed onset of central pontine myelinolysis despite appropriate correction of hyponatraemia. Intern Med J 32(5-6):273-274
8. Adrogué HJ, Madias NE (2000) Hyponatremia. N Engl J Med 342(21):1581-1589
9. Riggs JE, Schochet SS Jr (1989) Osmotic stress, osmotic myelinolysis, and oligodendrocyte topography. Arch Pathol Lab Med 113(12):1386-1388
10. Newell KL, Kleinschmidt-DeMasters BK (1996) Central pontine myelinolysis at autopsy; a twelve year retrospective analysis. J Neurol Sci 142(1-2):134-139
11. Gocht A, Colmant HJ (1987) Central pontine myelinolysis: a report of 58 cases. Clin Neuropathol 6:262-270
12. Bibl D, Lampl C, Gabriel C, Jüngling G, Brock H, Köstler G (1999) Treatment of central pontine myelinolysis with therapeutic plasmapheresis. Lancet 353(9159):1155
13. Finsterer J, Engelmayer E, Trnka E, Stiskal M (2000) Immunoglobulins are effective in pontine myelinolysis. Clin Neuropharmacol 23(2):110-113
14. Nakano H, Ohara Y, Bandoh K, Miyaoka M (1996) A case of central pontine myelinolysis after surgical removal of a pituitary tumor. Surg Neurol 46(1):32-36
15. Silver SM, Schroeder BM, Sterns RH, Rojiani AM (2006) Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. J Neuropathol Exp Neurol 65:37-44