Humanized antibodies with broad-spectrum neutralization to avian influenza virus H5N1

Antiviral Research

Volumn 87, Issue 1, 2010, Pages 81-84

  Chen, Yingwei ^a   Luo, Wenxin ^a   Wu, Wai Lan ^b   Fang, Zhong ^a   Xia, Lin ^a   Gui, Xun ^a   Chen, Yixin ^a   Chen, Honglin ^b   Shih, J Wai Kuo ^a   Xia, Ningshao ^a  

^a XIAMEN UNIVERSITY   (China)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Broad spectrum neutralization; H5N1; Humanized antibody

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 10F7; MONOCLONAL ANTIBODY 4D1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMAGGLUTINATION INHIBITION; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS NEUTRALIZATION; VIRUS VIRULENCE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; BODY WEIGHT; EPITOPE MAPPING; HEMAGGLUTINATION INHIBITION TESTS; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN VARIABLE REGION; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; MICE; NEUTRALIZATION TESTS; ORTHOMYXOVIRIDAE INFECTIONS; SURVIVAL ANALYSIS;

ANIMALIA; AVES; AVIAN INFLUENZA VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 77953535080     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2010.04.012     Document Type: Article

References (17)

1. Chen H., Smith G.J., Li K.S., Wang J., Fan X.H., Rayner J.M., Vijaykrishna D., Zhang J.X., Zhang L.J., Guo C.T., Cheung C.L., Xu K.M., Duan L., Huang K., Qin K., Leung Y.H., Wu W.L., Lu H.R., Chen Y., Xia N.S., Naipospos T.S., Yuen K.Y., Hassan S.S., Bahri S., Nguyen T.D., Webster R.G., Peiris J.S., Guan Y. Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:2845-2850.
2. Chen Y., Qin K., Wu .W.L., Li G., Zhang J., Du H., Ng M.H., Shih J.W., Peiris J.S., Guan Y., Chen H., Xia N. Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes. J. Infect. Dis. 2009, 199:49-58.
3. Dharan N.J., Gubareva L.V., Meyer J.J., Okomo-Adhiambo M., McClinton R.C., Marshall S.A., George St.K., Epperson S., Brammer L., Klimov A.I., Bresee J.S., Fry A.M. Infections with oseltamivir-resistant influenza A (H1N1) virus in the United States. JAMA 2009, 301:1034-1041. Oseltamivir-Resistance Working Group.
4. Duan L., Bahl J., Smith G.J., Wang J., Vijaykrishna D., Zhang L.J., Zhang J.X., Li K.S., Fan X.H., Cheung C.L., Huang K., Poon L.L., Shortridge K.F., Webster R.G., Peiris J.S., Chen H., Guan Y. The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. Virology 2008, 380:243-254.
5. Golemis E.A., Adams P.D. Protein-Protein Interactions: A Molecular Cloning Manual 2005, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 2nd ed.
6. Hanson B.J., Boon A.C., Lim A.P., Webb A., Ooi E.E., Webby R.J. Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice. Respir. Res. 2006, 7:126.
7. Kaverin N.V., Rudneva I.A., Ilyushina N.A., Varich N.L., Lipatov A.S., Smirnov Y.A., Govorkova E.A., Gitelman A.K., Lvov D.K., Webster R.G. Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants. J. Gen. Virol. 2002, 83:2497-2505.
8. Luke T.C., Kilbane E.M., Jackson J.L., Hoffman S.L. Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?. Ann. Intern. Med. 2006, 145:599-609.
9. Luo W., Chen Y., Li L., Xu C., Miao J., Shih J.W., Zhang J., Xia N. Construction and characterization of the chimeric antibody 8C11to the hepatitis E virus. FEMS Immunol. Med. Microbiol. 2007, 51:18-25.
10. Peiris J.S., de Jong M.D., Guan Y. Avian influenza virus (H5N1): a threat to human health. Clin. Microbiol. Rev. 2007, 20:243-267.
11. Prabakaran M., Prabhu N., He F., Hongliang Q., Ho H.T., Qiang J., Meng T., Goutama M., Kwang J. Combination therapy using chimeric monoclonal antibodies protects mice from lethal H5N1 infection and prevents formation of escape mutants. PLoS ONE 2009, 4:e5672.
12. Simmons C.P., Bernasconi N.L., Suguitan A.L., Mills K., Ward J.M., Chau N.V., Hien T.T., Sallusto F., Ha do Q., Farrar J., de Jong M.D., Lanzavecchia A., Subbarao K. Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Med. 2007, 4:e178.
13. Stevens J., Blixt O., Tumpey T.M., Taubenberger J.K., Paulson J.C., Wilson I.A. Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 2006, 312:404-410.
14. Throsby M., van den Brink E., Jongeneelen M., Poon L.L., Alard P., Cornelissen L., Bakker A., Cox F., van Deventer E., Guan Y., Cinatl J., ter Meulen J., Lasters I., Carsetti R., Peiris M., de Kruif J., Goudsmit J. Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS ONE 2008, 3:e3942.
15. Waldmann T.A., Morris J.C. Development of antibodies and chimeric molecules for cancer immunotherapy. Adv. Immunol. 2006, 90:83-131.
16. World Health Organization (WHO), 2009. Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO. Available at: http://www.who.int/csr/disease/avian_influenza/country/cases_table_2009_04_08/en/index.html.
17. Wu W.L., Chen Y., Wang P., Song W., Lau S.Y., Rayner J.M., Smith G.J., Webster R.G., Peiris J.S., Lin T., Xia N., Guan Y., Chen H. Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. J. Virol. 2008, 82:1798-1807.