PALB2 mutations in male breast cancer: A population-based study in Central Italy

Breast Cancer Research and Treatment

Volumn 122, Issue 1, 2010, Pages 299-301

  Silvestri, Valentina ^a   Rizzolo, Piera ^a   Zanna, Ines ^b   Falchetti, Mario ^a   Masala, Giovanna ^b   Bianchi, Simonetta ^c   Papi, Laura ^c   Giannini, Giuseppe ^a   Palli, Domenico ^b   Ottini, Laura ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; PALB2 PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; 5' UNTRANSLATED REGION; APOPTOSIS REGULATORY PROTEIN; BLID PROTEIN, HUMAN; BRCA2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PALB2 PROTEIN, HUMAN; PROTEIN BINDING; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; AMINO ACID SUBSTITUTION; BREAST CANCER; CONTROLLED STUDY; FAMILY HISTORY; GENE MUTATION; HETEROZYGOSITY; HUMAN; ITALY; LETTER; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NUCLEIC ACID BASE SUBSTITUTION; PENETRANCE; POPULATION GENETICS; PRIORITY JOURNAL; 5' UNTRANSLATED REGION; BREAST NEOPLASMS, MALE; CHEMISTRY; EXON; GENETIC PREDISPOSITION; GENETICS; GERMLINE MUTATION; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; POINT MUTATION; PROTEIN TERTIARY STRUCTURE; TUMOR SUPPRESSOR GENE; VERY ELDERLY;

5' UNTRANSLATED REGIONS; ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; BRCA2 PROTEIN; BREAST NEOPLASMS, MALE; DNA MUTATIONAL ANALYSIS; EXONS; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; ITALY; MALE; MIDDLE AGED; MUTATION, MISSENSE; NUCLEAR PROTEINS; PENETRANCE; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TUMOR SUPPRESSOR PROTEINS; APOPTOSIS REGULATORY PROTEINS;

EID: 77953534887     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0797-z     Document Type: Letter

References (10)

1. L Ottini D Palli S Rizzo M Federico V Bazan A Russo 2010 Male breast cancer Crit Rev Oncol Hematol 73 2 141 155 10.1016/j.critrevonc.2009.04.003 19427229
2. L Ottini P Rizzolo I Zanna M Falchetti G Masala K Ceccarelli V Vezzosi A Gulino G Giannini S Bianchi F Sera D Palli 2009 BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy Breast Cancer Res Treat 116 3 577 586 10.1007/s10549-008-0194-z 18819001
3. N Rahman S Seal D Thompson P Kelly A Renwick A Elliott S Reid K Spanova R Barfoot T Chagtai H Jayatilake L McGuffog S Hanks DG Evans D Eccles Breast Cancer Susceptibility Collaboration (UK) DF Easton MR Stratton 2007 PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene Nat Genet 39 2 165 167 10.1038/ng1959 1:CAS:528:DC%2BD2sXpvFeqsw%3D%3D 17200668 (Pubitemid 46184346)
4. AY Cao J Huang Z Hu WF Li ZL Ma LL Tang B Zhang FX Su J Zhou GH Di KW Shen J Wu JS Lu JM Luo WT Yuan ZZ Shen W Huang ZM Shao 2009 The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives Breast Cancer Res Treat 114 3 457 462 10.1007/s10549-008-0036-z 1:CAS:528:DC%2BD1MXisFSqt7o%3D 18446436
5. H Erkko B Xia J Nikkila J Schleutker K Syrjakoski A Mannermaa A Kallioniemi K Pylkas SM Karppinen K Rapakko A Miron Q Sheng G Li H Mattila DW Bell DA Haber M Grip M Reiman A Jukkola-Vuorinen A Mustonen J Kere LA Aaltonen VM Kosma V Kataja Y Soini RI Drapkin DM Livingston R Winqvist 2007 A recurrent mutation in PALB2 in Finnish cancer families Nature 446 7133 316 319 10.1038/nature05609 1:CAS:528:DC%2BD2sXivVSns78%3D 17287723 (Pubitemid 46426155)
6. C Thellenberg B Malmer B Tavelin H Grönberg 2003 Second primary cancers in men with prostate cancer: an increased risk of male breast cancer J Urol 169 4 1345 1348 10.1097/01.ju.0000056706.88960.7c 12629357 (Pubitemid 36323781)
7. Hemminki K, Scélo G, Boffetta P, Mellemkjaer L, Tracey E, Andersen A, Brewster DH, Pukkala E, McBride M, Kliewer EV, Chia K-S, Pompe-Kirn V, Martos C, Jonasson JG, Li X, Brennan P (2005) Second primary malignancies in patients with male breast cancer. Br J Cancer 92(7):1288-1292
8. Sauty de Chalon A, Teo Z, Park DJ, Odefrey FA, kConFab, Hopper JL, Southey MC (2009) Are PALB2 mutations associated with increased risk of male breast cancer? Breast Cancer Res Treat. doi: 10.1007/s10549-009-0673-x
9. Chen P, Liang J, Wang Z, Zhou X, Chen L, Li M, Xie D, Hu Z, Shen H, Wang H (2008) Association of common PALB2 polymorphisms with breast cancer risk: a case-control study. Clin Cancer Res 14(18):5931-5937
10. Cao AY, Yu KD, Yin WJ, Jin W, Di GH, Shen ZZ, Shao ZM (2009) Five common single nucleotide polymorphisms in the PALB2 gene and susceptibility to breast cancer in eastern Chinese population. Breast Cancer Res Treat. doi: 10.1007/s10549-009-0637-1