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1
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79951964692
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In vitro susceptibility testing: When, where, and what to use
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This detailed review describes reference and alternative approaches for susceptibility testing of yeasts and molds; their clinical relevance or lack thereof is also discussed
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Espinel-Ingroff A: In vitro susceptibility testing: when, where, and what to use. J Invasive Fungal Infect 2008, 2:52-61. This detailed review describes reference and alternative approaches for susceptibility testing of yeasts and molds; their clinical relevance or lack thereof is also discussed.
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(2008)
J Invasive Fungal Infect
, vol.2
, pp. 52-61
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Espinel-Ingroff, A.1
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2
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53349157204
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Epidemiology of invasive mold infections in allogeneic stem cell transplant recipients: Biological risk factors for infection according to time after transplantation
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A recent report of the epidemiology of mold infections is provided in this article
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Garcia-Vidal C, Upton A, Kirby KA, Marr KA: Epidemiology of invasive mold infections in allogeneic stem cell transplant recipients: biological risk factors for infection according to time after transplantation. Clin Infect Dis 2008, 47:1041-1050. A recent report of the epidemiology of mold infections is provided in this article.
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(2008)
Clin Infect Dis
, vol.47
, pp. 1041-1050
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Garcia-Vidal, C.1
Upton, A.2
Kirby, K.A.3
Marr, K.A.4
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3
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58749083534
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Epidemiology and outcome of invasive fungal infections in adult hematopoietic stem cell transplant recipients: Analysis of multicenter PATH Alliance Registry
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This article provides a recent report of the epidemiology and the outcome of mold infections in this group of patients
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Neofytos D, Horn D, Anaissie E, et al.: Epidemiology and outcome of invasive fungal infections in adult hematopoietic stem cell transplant recipients: analysis of multicenter PATH Alliance Registry. Clin Infect Dis 2009, 48:265-273. This article provides a recent report of the epidemiology and the outcome of mold infections in this group of patients.
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(2009)
Clin Infect Dis
, vol.48
, pp. 265-273
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Neofytos, D.1
Horn, D.2
Anaissie, E.3
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4
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56749159784
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Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism
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This study reports on the emergence and prevalence of itraconazole resistance in A. fumigatus during the past 14 years in The Netherlands. Itraconazole resistance was associated with reduced susceptibility to other triazoles
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Snelders E, van der Lee HA, Kuijpers J, et al.: Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. PLoS Med 2008, 5:1629-1637. This study reports on the emergence and prevalence of itraconazole resistance in A. fumigatus during the past 14 years in The Netherlands. Itraconazole resistance was associated with reduced susceptibility to other triazoles.
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(2008)
PLoS Med
, vol.5
, pp. 1629-1637
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Snelders, E.1
Van Der Lee, H.A.2
Kuijpers, J.3
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5
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53149135483
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In vitro survey of triazole cross-resistance among more than 700 clinical isolates of Aspergillus spp.
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This article provides the incidence of triazole resistance in various Aspergillus spp isolates
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Pfaller MA, Messer SA, Boyken L, et al.: In vitro survey of triazole cross-resistance among more than 700 clinical isolates of Aspergillus spp. J Clin Microbiol 2008, 46:2568-2572. This article provides the incidence of triazole resistance in various Aspergillus spp isolates.
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(2008)
J Clin Microbiol
, vol.46
, pp. 2568-2572
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Pfaller, M.A.1
Messer, S.A.2
Boyken, L.3
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6
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55249114346
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Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylase A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus
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This article reports on the molecular characterization of voriconazole resistance in A. flavus
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Krishnan-Natesan S, Chandrasekar PH, Alangaden GJ, Manavathu EK: Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylase A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus. Int J Antimicrob Agents 2008, 32:519-524. This article reports on the molecular characterization of voriconazole resistance in A. flavus.
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(2008)
Int J Antimicrob Agents
, vol.32
, pp. 519-524
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Krishnan-Natesan, S.1
Chandrasekar, P.H.2
Alangaden, G.J.3
Manavathu, E.K.4
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7
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34250223076
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A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations
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This article describes a new molecular azole resistance mechanism in A. fumigatus
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Mellado E, Garcia-Effron G, Alcazar-Fuoli L, et al.: A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. Antimicrob Agents Chemother 2007, 51:1897-1904. This article describes a new molecular azole resistance mechanism in A. fumigatus.
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(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 1897-1904
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Mellado, E.1
Garcia-Effron, G.2
Alcazar-Fuoli, L.3
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8
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35848964834
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A ser67Pro substitution in Fk51p confers resistance to echinocandin drugs in Aspergillus fumigatus
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A similar mutation to that associated with echinocandin resistance in Candida albicans was also associated with resistance to echinocandins in A. fumigatus
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Rocha EM, Garcia-Effron G, Park S, Perlin DS: A ser67Pro substitution in Fk51p confers resistance to echinocandin drugs in Aspergillus fumigatus. Antimicrob Agents Chemother 2007, 51:4174-4176. A similar mutation to that associated with echinocandin resistance in Candida albicans was also associated with resistance to echinocandins in A. fumigatus.
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(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 4174-4176
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Rocha, E.M.1
Garcia-Effron, G.2
Park, S.3
Perlin, D.S.4
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9
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42049089497
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Potential basis for amphotericin B resistance in Aspergillus terreus
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This article investigated the basis for the intrinsic resistance of A. terreus to amphotericin B. The authors concluded that high catalase levels may be the cause of resistance
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Blum G, Perkhofer S, Haas H, et al.: Potential basis for amphotericin B resistance in Aspergillus terreus. Antimicrob Agents Chemother 2008, 52:1553-1555. This article investigated the basis for the intrinsic resistance of A. terreus to amphotericin B. The authors concluded that high catalase levels may be the cause of resistance.
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Antimicrob Agents Chemother
, vol.52
, pp. 1553-1555
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Blum, G.1
Perkhofer, S.2
Haas, H.3
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10
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46249109837
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Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus
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This article provides the epidemiological cutoffs for A. fumigatus and four triazoles by the EUCAST method; the cutoff was lower for posaconazole. Triazole cross-resistance was associated with specific cyp51A mutations
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Rodriguez-Tudela JL, Alcazar-Fuoli L, Mellado E, et al.: Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus. Antimicrob Agents Chemother 2008, 52:2468-2472. This article provides the epidemiological cutoffs for A. fumigatus and four triazoles by the EUCAST method; the cutoff was lower for posaconazole. Triazole cross-resistance was associated with specific cyp51A mutations.
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(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 2468-2472
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Rodriguez-Tudela, J.L.1
Alcazar-Fuoli, L.2
Mellado, E.3
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12
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44849143048
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Mechanisms of resistance to antifungal agents: Yeasts and filamentous fungi
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This paper provides a comprehensive review of the literature (2005-2008) regarding molecular mechanisms of resistance and their correlation with in vitro and in vivo results for yeasts and molds
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Espinel-Ingroff A: Mechanisms of resistance to antifungal agents: yeasts and filamentous fungi. Rev Iberoam Micol 2008, 25:99-104. This paper provides a comprehensive review of the literature (2005-2008) regarding molecular mechanisms of resistance and their correlation with in vitro and in vivo results for yeasts and molds.
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Rev Iberoam Micol
, vol.2008
, Issue.25
, pp. 99-104
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Espinel-Ingroff, A.1
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13
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0031059950
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Multicenter evaluation of proposed standardized procedure for antifungal susceptibility testing of filamentous fungi
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Espinel-Ingroff A, Bartlett M, Bowden, R, et al.: Multicenter evaluation of proposed standardized procedure for antifungal susceptibility testing of filamentous fungi. J Clin Microbiol 1997, 35:139-143. (Pubitemid 26422642)
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Journal of Clinical Microbiology
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Espinel-Ingroff, A.1
Bartlett, M.2
Bowden, R.3
Chin, N.X.4
Cooper Jr., C.5
Fothergill, A.6
McGinnis, M.R.7
Menezes, P.8
Messer, S.A.9
Nelson, P.W.10
Odds, F.C.11
Pasarell, L.12
Peter, J.13
Pfaller, M.A.14
Rex, J.H.15
Rinaldi, M.G.16
Shankland, G.S.17
Walsh, T.J.18
Weitzman, I.19
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14
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0035007179
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Optimal susceptibility testing conditions for detection of azole resistance in Aspergillus spp.: NCCLS collaborative evaluation
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DOI 10.1128/AAC.45.6.1828-1835.2001
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Espinel-Ingroff A, Bartlett M, Chaturvedi V, et al.: Optimal susceptibility testing conditions for detection of azole resistance in Aspergillus spp.: NCCLS collaborative evaluation. Antimicrob Agents Chemother 2001, 45:1828-1835. (Pubitemid 32466356)
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Antimicrobial Agents and Chemotherapy
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Espinel-Ingroff, A.1
Bartlett, M.2
Chaturvedi, V.3
Ghannoum, M.4
Hazen, K.C.5
Pfaller, M.A.6
Rinaldi, M.7
Walsh, T.J.8
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15
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0036790126
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Optimal testing conditions for determining MICs and minimum fungicidal concentrations of new and established antifungal agents for uncommon molds: NCCLS collaborative study
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Espinel-Ingroff A, Chaturvedi V, Fothergill A, Rinaldi MG: Optimal testing conditions for determining MICs and minimum fungicidal concentrations of new and established antifungal agents for uncommon molds: NCCLS collaborative study. J Clin Microbiol 2002, 40:3776-3781.
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J Clin Microbiol
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Espinel-Ingroff, A.1
Chaturvedi, V.2
Fothergill, A.3
Rinaldi, M.G.4
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16
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0028836230
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Comparative and collaborative evaluation of standardization of antifungal susceptibility testing for filamentous fungi
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Espinel-Ingroff A, Dawson K, Pfaller MA, et al.: Comparative and collaborative evaluation of standardization of antifungal susceptibility testing for filamentous fungi. Antimicrob Agents Chemother 1995, 39:314-319.
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Antimicrob Agents Chemother
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Espinel-Ingroff, A.1
Dawson, K.2
Pfaller, M.A.3
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17
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66149144127
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Clinical and Laboratory Standards Institute/National Committee for Clinical Laboratory Standards: edn 2; Document M38-A2. Wayne, PA: Clinical and Laboratory Standards Institute; This recently published CLSI document describes in detail the new testing guidelines for susceptibility testing of molds, including those for the echinocandins
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Clinical and Laboratory Standards Institute/National Committee for Clinical Laboratory Standards: Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved Standard, edn 2; Document M38-A2. Wayne, PA: Clinical and Laboratory Standards Institute; 2008. This recently published CLSI document describes in detail the new testing guidelines for susceptibility testing of molds, including those for the echinocandins.
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(2008)
Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi. Approved Standard
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18
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34250654094
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Muticenter evaluation of a new disk agar diffusion method for susceptibility testing of filamentous fungi with voriconazole, posaconazole, itraconazole, amphotericin B and caspofungin
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The guidelines for testing molds by the disk diffusion method were identified during this CLSI collaborative study. In vitro MIC and MEC breakpoints as well interpretive zone diameters were assigned
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Espinel-Ingroff A, Arthington-Skaggs B, Iqbal N, et al.: Muticenter evaluation of a new disk agar diffusion method for susceptibility testing of filamentous fungi with voriconazole, posaconazole, itraconazole, amphotericin B and caspofungin. J Clin Microbiol 2007, 45:1811-1820. The guidelines for testing molds by the disk diffusion method were identified during this CLSI collaborative study. In vitro MIC and MEC breakpoints as well interpretive zone diameters were assigned.
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(2007)
J Clin Microbiol
, vol.45
, pp. 1811-1820
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Espinel-Ingroff, A.1
Arthington-Skaggs, B.2
Iqbal, N.3
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19
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0037234835
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Evaluation of broth microdilution testing parameters and agar diffusion Etest procedure for testing susceptibilities of Aspergillus spp. to caspofungin acetate (MK-0991)
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Espinel-Ingroff A: Evaluation of broth microdilution testing parameters and agar diffusion Etest procedure for testing susceptibilities of Aspergillus spp. to caspofungin acetate (MK-0991). J Clin Microbiol 2003, 41:403-409.
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J Clin Microbiol
, vol.41
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Espinel-Ingroff, A.1
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20
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34547614064
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Quality control and reference guidelines for CLSI broth microdilution method (M38-A document) for susceptibility testing of anidulafungin against molds
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This article describes the first collaborative study conducted for the selection of quality control isolates and establishment of MEC limits for mold testing with anidulafungin
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Espinel-Ingroff A, Fothergill A, Ghannoum M, et al.: Quality control and reference guidelines for CLSI broth microdilution method (M38-A document) for susceptibility testing of anidulafungin against molds. J Clin Microbiol 2007, 45:2180-2182. This article describes the first collaborative study conducted for the selection of quality control isolates and establishment of MEC limits for mold testing with anidulafungin.
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J Clin Microbiol
, vol.45
, pp. 2180-2182
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Espinel-Ingroff, A.1
Fothergill, A.2
Ghannoum, M.3
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21
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3843088493
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Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species
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DOI 10.1128/JCM.42.8.3475-3482.2004
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Odds FC, Motyl M, Andrade R, et al.: Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species. J Clin Microbiol 2004, 42:3475-3482. (Pubitemid 39045669)
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Journal of Clinical Microbiology
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Odds, F.C.1
Motyl, M.2
Andrade, R.3
Bille, J.4
Canton, E.5
Cuenca-Estrella, M.6
Davidson, A.7
Durussel, C.8
Ellis, D.9
Foraker, E.10
Fothergill, A.W.11
Ghannoum, M.A.12
Giacobbe, R.A.13
Gobernado, M.14
Handke, R.15
Laverdiere, M.16
Lee-Yang, W.17
Merz, W.G.18
Ostrosky-Zeichner, L.19
Peman, J.20
Perea, S.21
Perfect, J.R.22
Pfaller, M.A.23
Proia, L.24
Rex, J.H.25
Rinaldi, M.G.26
Rodriguez-Tudela, J.-L.27
Schell, W.A.28
Shields, C.29
Sutton, D.A.30
Verweij, P.E.31
Warnock, D.W.32
more..
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22
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34447265453
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In vitro susceptibilities of 217 clinical isolates of Zygomycetes to conventional and new antifungal agents
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This paper provides in vitro data for a large number of mucoraceous isolates
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Almyroudis NG, Sutton DA, Fothergill AW, et al.: In vitro susceptibilities of 217 clinical isolates of Zygomycetes to conventional and new antifungal agents. Antimicrob Agents Chemother 2007, 51:2587-2590. This paper provides in vitro data for a large number of mucoraceous isolates.
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Antimicrob Agents Chemother
, vol.51
, pp. 2587-2590
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Almyroudis, N.G.1
Sutton, D.A.2
Fothergill, A.W.3
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23
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26944500560
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Quality control and reference guidelines for CLSI broth microdilution susceptibility method (M38-A document) for amphotericin B, itraconazole, posaconazole, and voriconazole
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DOI 10.1128/JCM.43.10.5243-5246.2005
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Espinel-Ingroff A, Fothergill, A, Ghannoum, M, et al.: Quality control and reference guidelines for CLSI broth microdilution susceptibility method (M38-A document) of amphotericin B, itraconazole, posaconazole and voriconazole. J Clin Microbiol 2005, 43:5243-5246. (Pubitemid 41484032)
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Journal of Clinical Microbiology
, vol.43
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Manavathu, E.4
Ostrosky-Zeichner, L.5
Pfaller, M.6
Rinaldi, M.7
Schell, W.8
Walsh, T.9
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24
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0036093584
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Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits
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DOI 10.1128/AAC.46.6.1857-1869.2002
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Petraitis V, Petraitiene R, Groll AH, et al.: Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive aspergillosis in persistently neutropenic rabbits. Antimicrob Agents Chemother 2002, 46:1857-1869. (Pubitemid 34535208)
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Antimicrobial Agents and Chemotherapy
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Petraitis, V.1
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Hemmings, M.5
Lyman, C.A.6
Sein, T.7
Bacher, J.8
Bekersky, I.9
Walsh, T.J.10
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25
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0036733374
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Pseudallescheria boydii (anamorph Scedosporium apiospermum) infection in solid organ transplant recipients in a tertiary medical center and review of the literature
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Castiglioni B, Sutton DA, Rinaldi MG, et al.: Pseudallescheria boydii (anamorph Scedosporium apiospermum) infection in solid organ transplant recipients in a tertiary medical center and review of the literature. Medicine 2002, 81:333-348.
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Medicine
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In-vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis
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DOI 10.1093/jac/42.4.497
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Niederwieser, D.7
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27
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0038519302
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Genetic diversity among clinical isolates of Acremonium strictum determined during an investigation of a fatal mycosis
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Novicki TJ, LaFe K, Bui L, et al.: Genetic diversity among clinical isolates of Acremonium strictum determined during an investigation of a fatal mycosis. J Clin Microbiol 2003, 41:2623-2628. (Pubitemid 36712476)
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28
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0030824612
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Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus Infection
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DOI 10.1093/jac/40.3.401
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29
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40049093551
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Activities of voriconazole, itraconazole and amphotericin B in vitro against 590 moulds from 323 patients in voriconazole phase III clinical studies
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This is the first report of the data obtained for all filamentous fungi that were recovered during voriconazole phase 3 clinical trials. The clinical response to voriconazole therapy during these studies is described, as well as the in vitro susceptibilities of these isolates to three other antifungal agents
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Espinel-Ingroff A, Johnson E, Hockey H, Troke PF: Activities of voriconazole, itraconazole and amphotericin B in vitro against 590 moulds from 323 patients in voriconazole phase III clinical studies. J Antimicrob Chemother 2008, 61:616-620. This is the first report of the data obtained for all filamentous fungi that were recovered during voriconazole phase 3 clinical trials. The clinical response to voriconazole therapy during these studies is described, as well as the in vitro susceptibilities of these isolates to three other antifungal agents.
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J Antimicrob Chemother
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Espinel-Ingroff, A.1
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42949088904
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Treatment of scedosporiosis with voriconazole: Clinical experience with 107 patients
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This is a report of relevant data regarding the clinical response to voriconazole therapy for a large number of patients with scedosporiosis
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Troke P, Aguirrebengoa K, Arteaga C, et al.: Treatment of scedosporiosis with voriconazole: clinical experience with 107 patients. Antimicrob Agents Chemother 2008, 52:1743-1750. This is a report of relevant data regarding the clinical response to voriconazole therapy for a large number of patients with scedosporiosis.
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Troke, P.1
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0035984835
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In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model
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DOI 10.1128/AAC.46.7.2310-2312.2002
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Sun QN, Najvar LK, Bocanegra R, et al.: In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model. Antimicrob Agents Chemother 2002, 46:2310-2312. (Pubitemid 34665939)
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33845710284
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Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: An externally controlled trial
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In this study, posaconazole plasma concentrations correlated with patient outcome; high plasma concentrations were associated with higher response to posaconazole therapy for invasive aspergillosis
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Walsh TJ, Raad I, Patterson TF, et al.: Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clin Infect Dis 2007, 44:2-12. In this study, posaconazole plasma concentrations correlated with patient outcome; high plasma concentrations were associated with higher response to posaconazole therapy for invasive aspergillosis.
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Clinical and Laboratory Standards Institute/National Committee for Clinical Laboratory Standards: edn 3; Document M27-A3. Wayne, PA: Clinical and Laboratory Standards Institute; This CLSI document describes in detail the new guidelines for testing yeasts, including those for the echinocandins. The newly established echinocandin-susceptible breakpoint for Candida spp is also described
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Clinical and Laboratory Standards Institute/National Committee for Clinical Laboratory Standards: Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved Standard, edn 3; Document M27-A3. Wayne, PA: Clinical and Laboratory Standards Institute; 2008. This CLSI document describes in detail the new guidelines for testing yeasts, including those for the echinocandins. The newly established echinocandin-susceptible breakpoint for Candida spp is also described.
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(2008)
Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved Standard
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34
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Comparison of the Sensititre YeastOne colorimetric antifungal panel and Etest with the NCCLS M38-A method to determine the activity of amphotericin B and itraconazole against clinical isolates of Aspergillus spp
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Martin-Mazuelos E, Peman J, Valverde A, et al.: Comparison of the Sensititre YeastOne colorimetric antifungal panel and Etest with the NCCLS M38-A method to determine the activity of amphotericin B and itraconazole against clinical isolates of Aspergillus spp. J Antimicrob Chemother 2003, 52:365-370. (Pubitemid 37120713)
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Comparison of three commercial assays and a modified disk diffusion assay with two broth microdilution reference assays for testing Zygomycetes, Aspergillus spp., Candida spp., and Cryptococcus neoformans with posaconazole and amphotericin B
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This paper describes the comparison of three commercial assays (Etest, YeastOne, and Neo-Sensitabs) with reference broth dilution and disk diffusion methods for testing posaconazole and amphotericin B for a large number of yeasts, including Cryptococcus neoformans, Aspergillus spp, and mucoraceous isolates
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The first comparison of the Neo-Sensitabs tablet method with both disk and broth dilution reference methods for mold testing is provided in this article
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Espinel-Ingroff A, Canton E: Comparison of Neo-Sensitabs tablet diffusion assay with CLSI broth microdilution M38-A and disk diffusion methods for testing susceptibility of filamentous fungi with amphotericin B, caspofungin, itraconazole, posaconazole and voriconazole. J Clin Microbiol 2008, 46:1793-1803. The first comparison of the Neo-Sensitabs tablet method with both disk and broth dilution reference methods for mold testing is provided in this article.
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Espinel-Ingroff A, Rezusta A: E-test method for testing susceptibilities of Aspergillus spp. to the new triazoles voriconazole and posaconazole and to established antifungal agents: comparison with NCCLS broth microdilution method. J Clin Microbiol 2002, 40:2101-2107. (Pubitemid 34596392)
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Pfaller JB, Messer SA, Hollis RJ, et al.: In vitro susceptibility testing of Aspergillus spp.: comparison of Etest and reference microdilution methods for determining voriconazole and itraconazole MICs. J Clin Microbiol 2003, 41:1126-1129. (Pubitemid 36307117)
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Meletiadis J, Antachopoulos C, Stergiopoulou T, et al.: Differential fungicidal activities of amphotericin B and voriconazole against Aspergillus species by microbroth methodology. Antimicrob Agents Chemother 2007, 51:3329-3337. This article reports a novel and shorter method for determining the fungicidal susceptibilities of Aspergillus to two antifungal agents.
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