Up-regulation of Idh3α causes reduction of neuronal differentiation in PC12 cells

BMB Reports

Volumn 43, Issue 5, 2010, Pages 369-374

  Cho, Sun A ^a   Seo, Min Ji ^a   Ko, Je Yeong ^a   Shim, Jung Hee ^a   Yoo, Jin ^a   Kim, Jung Hee ^a   Kim, Se Yoon ^b   Ryu, Na Kyung ^a   Park, Eun Young ^a   Lee, Han Woong ^c   Lee, Yeon Su ^d   Bahk, Young Yil ^b   Park, Jong Hoon ^a  

^a Sookmyung Women's University   (South Korea)

^b Protein Network Research Center   (South Korea)

^c Yonsei University   (South Korea)

^d National Cancer Center   (South Korea)

Author keywords

2 DE; Idh3 ; Neuronal differentiation; NGF; PC12 cell

Indexed keywords

ISOCITRATE DEHYDROGENASE; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PROTEOME;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CYTOLOGY; GENETICS; MASS SPECTROMETRY; METABOLISM; NERVE CELL; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; ISOCITRATE DEHYDROGENASE; ISOENZYMES; NEURONS; PC12 CELLS; PROTEOME; RATS; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; UP-REGULATION;

EID: 77953525411     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2010.43.5.369     Document Type: Article

References (11)

1. Greene, L. A. and Tischler, A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. U.S.A. 73, 2424-2428.
2. Koike, T., Uno, S., Ishizawa, M., Takahashi, H., Ikeda, K., Yokota, S. and Makishima, M. (2006) The heat shock protein inhibitor KNK437 induces neurite outgrowth in PC12 cells. Neurosci. Lett. 410, 212-217.
3. Selkoe, D. J. (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791.
4. Gurok, U., Bork, K., Nuber, U., Sporle, R., Nohring, S. and Horstkorte, R. (2007) Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development. Gene. Expr. Patterns. 7, 370-374.
5. Ramachandran, N. and Colman, R. F. (1980) Chemical characterization of distinct subunits of pig heart DPN-specific isocitrate dehydrogenase. J. Biol. Chem. 255, 8859-8864.
6. Kim, Y. O., Koh, H. J., Kim, S. H., Jo, S. H., Huh, J. W., Jeong, K. S., Lee, I. J., Song, B. J. and Huh, T. L. (1999) Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform. J. Biol. Chem. 274, 36866-36875.
7. Cankaya, M., Hernandez, A. M., Ciftci, M., Beydemir, S., Ozdemir, H., Budak, H., Gulcin, I., Comakli, V., Emircupani, T., Ekinci, D., Kuzu, M., Jiang, Q., Eichele, G. and Kufrevioglu, O. I. (2007) An analysis of expression patterns of genes encoding proteins with catalytic activities. BMC Genomics 8, 232.
8. Sun, P., Watanabe, H., Takano, K., Yokoyama, T., Fujisawa, J. and Endo, T. (2006) Sustained activation of M-Ras induced by nerve growth factor is essential for neuronal differentiation of PC12 cells. Genes. Cells. 11, 1097-1113.
9. Rudkin, B. B., Lazarovici, P., Levi, B. Z., Abe, Y., Fujita, K. and Guroff, G. (1989) Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation. EMBO J. 8, 3319-3325.
10. Qui, M. S. and Green, S. H. (1992) PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity. Neuron 9, 705-717.
11. York, R. D., Yao, H., Dillon, T., Ellig, C. L., Eckert, S. P., McCleskey, E. W. and Stork, P. J. (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392, 622-626.