Trapping of fatty acid allyl radicals generated in lipoxygenase reactions in biological fl uids by nitroxyl radical

Biomedical Chromatography

Volumn 24, Issue 7, 2010, Pages 794-797

  Takajo, Tokuko ^a   Tsuchida, Kazunori ^a   Yokota, Azusa ^b   Koshiishi, Ichiro ^b  

^a NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Biological fluid; Fatty acid allyl radical; Lipoxygenases; Nitroxyl radical; Spin trapping

Indexed keywords

BIOMARKERS; BODY FLUIDS; CHEMICAL DETECTION; FATTY ACIDS; REACTION INTERMEDIATES;

ALLYL RADICALS; BIOLOGICAL FLUIDS; ELECTROCHEMICAL DETECTION; FATTY ACID ALLYL RADICAL; LIPOXYGENASES; LOW OXYGEN CONTENTS; NITROXYL RADICAL; RADICAL TRAPPING; RADICAL-ADDUCTS; SPIN TRAPPING;

ANTIOXIDANTS;

3 CARBAMOYL 2,2,5,5 TETRAMETHYL 3 PYRROLINE 1 OXYL; FATTY ACID; LIPOXYGENASE;

ARTICLE; BODY FLUID; CENTRIFUGATION; ELECTROCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; RAT; SOYBEAN;

GLYCINE MAX; RATTUS;

EID: 77953524440     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1398     Document Type: Article

References (13)

1. Arai K, Nishiyama N, Matsuki N and Ikegaya Y. Neuroprotective eff ects of lipoxygenase inhibitors against ischemic injury in rat hippocampal slice cultures. Brain Research 2001; 904: 167-172. (Pubitemid 32545369)
2. Jung G, Yang DC and Nakao A. Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase. Biochemical and Biophysical Research Communications 1985: 130: 559-566. (Pubitemid 16239379)
3. Kato N, Yanaka K, Hyodo K, Homma K, Nagase S and Nose T. Stable nitroxide Tempol ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischemia. Brain Research 2003; 979: 188-193. (Pubitemid 36792169)
4. Koshiishi I, Tsuchida K, Takajo T and Komatsu M. Quantifi cation of lipid alkyl radicals trapped with nitroxyl radical via HPLC with postcolumn thermal decomposition. Journal of Lipid Research 2005; 46:2506-2513. (Pubitemid 41532539)
5. Koshiishi I, Tsuchida K, Takajo T and Komatsu M. Radical scavenger can scavenge lipid allyl radicals complexed with lipoxygenase at lower oxygen content. Biochemical Journal 2006; 395: 303-309.
6. Nelson MJ, Seitz SP and Cowling RA. Enzyme-bound pentadienyl and peroxyl radicals in purple lipoxygenase. Biochemistry 1990; 29:6897-6903. (Pubitemid 20225491)
7. Patel NS, Cuzzocrea S, Chatterjee PK, Di Paola R, Sautebin L, Britti D and Thiemermann C. Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. Molecular Pharmacology 2004; 66: 220-227. (Pubitemid 38989478)
8. Phillis JW and O'Regan MH. The role of phospholipases, cyclooxigenases, and lipoxygenases in cerebral ischemic/traumatic injuries. Critical Review in Neurobiology 2003; 15: 61-90.
9. Rak R, Chao DL, Pluta RM, Mitchell JB, Oldfi eld EH and Watson JC. Neuroprotection by the stable nitroxide Tempol during reperfusion in a rat model of transient focal ischemia. Journal of Neurosurgery 2000; 92:646-651. (Pubitemid 30180671)
10. Schneider C, Pratt DA, Porter NA and Brash AR. Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. Chemistry and Biology 2007; 14: 473-488. (Pubitemid 46765155)
11. Takajo T, Tsuchida K, Murahashi T, Ueno K and Koshiishi I. Intamolecular rearrangement of linoleate peroxyl radicals in lipoxygenase reactions at lower oxygen content. Journal of Lipid Research 2007a; 48:855-862. (Pubitemid 46557890)
12. Takajo T, Tsuchida K, Ueno K and Koshiishi I. Feedback activation of ferrous 5-lipoxygenase in leukotriene synthesis by coexisting linoleic acid. Journal of Lipid Research 2007b; 48: 1371-1377. (Pubitemid 47312039)
13. Zhang R, Shohami E, Beit-Yannai E, Bass R, Trembovler V and Samuni A. Mechanism of brain protection by nitroxide radicals in experimental model of closed-head injury. Free Radical Biology and Medicine 1998;24: 332-340.