Antiprotozoal activity and cytotoxicity of metabolites from leaves of Teclea trichocarpa

Journal of Medicinal Plants Research

Volumn 4, Issue 9, 2010, Pages 726-731

  Mwangi, E S K ^a   Keriko, J M ^a   Machocho, A K ^b   Wanyonyi, A W ^b   Malebo, H M ^b   Chhabra, S C ^b   Tarus, P K ^c  

^a JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Kenya)

^b KENYATTA UNIVERSITY   (Kenya)

^c MASINDE MULIRO UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Kenya)

Author keywords

Alkaloids; Cytotoxicity; Protozoa; Teclea trichocarpa

Indexed keywords

ALKALOID; ALPHA AMYRIN; ARBORININE; BENZNIDAZOLE; CHLOROQUINE; HERBACEOUS AGENT; MELARSOPROL; MELICOPICINE; METHANOL; MILTEFOSINE; NORMELICOPICINE; SITOSTEROL; SKIMMIANINE; TECLEA TRICHOCARPA EXTRACT; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; IC 50; IN VITRO STUDY; LEISHMANIA DONOVANI; MOUSE; NONHUMAN; PLANT LEAF; PLASMODIUM FALCIPARUM; RAT; RUTACEAE; SOLVENT EXTRACTION; TECLEA TRICHOCARPA; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

LEISHMANIA DONOVANI; PLASMODIUM FALCIPARUM; PROTOZOA; RUTACEAE; TECLEA; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 77953519673     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Allan F, Alcira AB, Victoria M, Reynald H, Andre C, Jean B (1993). 2-Substituted quinoline alkaloids as potential antileishmanial drugs. Antimicrob. Agents Chemother. 37: 859-963.
2. Ambrozin ARP, Mafezoli J, Vieira PC, Fernandes JB, Silva MFGF, Ellena JA, Albuquerque S (2005). New pyrone and quinoline alkaloid from Almeidea rubra and their trypanocidal actvities. J. Br. Chem. Soc. 16: 434-439.
3. 13C-NMR-spektren einiger acridon-alkaloide. Phytochem. 18: 161-163.
4. th edn, London: W.B. Saunders and Co. pp. 1213-1245.
5. Cunningham I (1977). New culture medium for maintenance of tsetse tissues and growth of trypanosomatids. J. Protozool. 24: 325-329.
6. Howard RJ (1987). Vaccination against malaria: Recent advances and the problems of antigenic diversity and other parasite evasion mechanism. Int. J. Parasitol. 17: 17-29.
7. Houghton PJ (2001). Old yet new-pharmaceuticals from pants. J. Chem. Edu. 78: 175-184.
8. Kain KC (1995). Chemotherapy and prevention of drug-resistant malaria. Wilderness Environ. Med. 6: 307-324.
9. Kiprono CP, Kaberia F, Karanja JN, Keriko JM (2000). The in vitro antifungal and antibacterial activities of β-sitosterol from Senecio lyratus (Asteraceae). Z. Naturforsh. 55: 485-488.
10. Lwande W, Gebreyesus T, Chapya A, Macfoy C, Hassanali A, Okech MM (1983). 9-Acridone insect antifeedant alkaloids from Teclea trichocarpa bark. Insect Sci. Appl. 4: 393-395.
11. 13C NMR spectra of pentacyclic triterpenoids-a complilation and some salient features. Phytochem. 37: 1517-1575.
12. Mascolo N, Pinto A, Yenesew A, Dagne E (1988). Antipyretic and analgesic studies of the ethanolic extract of Teclea nobilis Delile. Phytother. Res. 2: 154-156.
13. Matile H, Pink JRL (1990). Plasmodium falciparum malaria parasite cultures and their use in immunology. In: Lefkovits, I., Pernis, B. (eds.). Immunological Methods. San Diego: Academic press pp. 221-234.
14. th edn, London: W.B. Saunders and Co. pp. 1171-1196.
15. Muriithi MW, Abraham WR, Addae-Kyereme J, Scowen I, Croft SL, Gitu PM, Kendrick H, Njagi ENM, Wright CW (2002). Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and x-ray crystal structure of normelicopicine. J. Nat. Prod. 65: 956-959.
16. Olliaro P, Cattani J, Wirth D (1996). Malaria: the submerged disease. JAMA 275: 230-234.
17. 13C NMR data. Fitoterapia 70: 625-627.
18. Räz B, Iten M, Grether-Buhler Y, Kaminsky R, Brun R (1997). The Alamar blue assay to determine drug sensitivity of African trypanosomes (Trypanosoma brucei rhodesiense and T. b. gambiense) Acta Trop. 68: 139-147.
19. Ridley RG, Hofheinz W, Matile H, Jaquet C, Dorn A, Masciadri R, Jolidon S, Richter WF, Guenzi A, Girometta MA, Urwyler H, Huber W, Thaithong S, Peters W (1996). 4-Aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum. Antimicrob. Agents Chemother. 40: 1846-1854.
20. nd ed, Edinburgh: E. & S. Livingstone Ltd p. 923.
21. WHO (1984). Chemical Methods for the Control of Arthropod Vectors and Pests of Public Health Importance. Geneva: World Health Organization p. 108.
22. WHO (2002). The World Health Report 2002: Reducing Risks, Prompting Healthy Life. Geneva: World Health Organization p. 248.
23. Wright CW, Phillipson JD (1990). Natural products and the development of selective antiprotozoal drugs. Phytother. Res. 4: 127-139