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Volumn 49, Issue 25, 2010, Pages 4228-4232

Striking inflammation from both sides: Manganese(II) pentaazamacrocyclic SOD mimics act also as nitric oxide dismutases: A single-cell study

Author keywords

Inflammation; Macrocyclic ligands; Manganese; Nitric oxide; Sod mimics

Indexed keywords

AMPEROMETRY; CYTOTOXIC EFFECTS; INFLAMMATION; MACROCYCLIC LIGANDS; PENTAAZAMACROCYCLIC; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN; SINGLE CELLS;

EID: 77953485055     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200905936     Document Type: Article
Times cited : (49)

References (36)
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    • Angew. Chem. Int. Ed. 2008, 47, 8735-8739.
    • (2008) Angew. Chem. Int. Ed. , vol.47 , pp. 8735-8739
  • 19
    • 77953498678 scopus 로고    scopus 로고
    • The complex should be used at sufficiently low concentrations to present low toxicity to RAW 264.7 macrophages and exclude the detection of ROS/RNS released by apoptotic cells. Conversely, a sufficiently high concentration was needed for the effects from the Mn SOD mimic to be more apparent. These boundaries defined the experimental concentration range used in this study
    • The complex should be used at sufficiently low concentrations to present low toxicity to RAW 264.7 macrophages and exclude the detection of ROS/RNS released by apoptotic cells. Conversely, a sufficiently high concentration was needed for the effects from the Mn SOD mimic to be more apparent. These boundaries defined the experimental concentration range used in this study.
  • 20
    • 77953532321 scopus 로고    scopus 로고
    • Experimental details, as well as supporting text and references, are given in the Supporting Information
    • Experimental details, as well as supporting text and references, are given in the Supporting Information.
  • 22
    • 77953514950 scopus 로고    scopus 로고
    • The addition of cytotoxic agents will lead to metabolic dysfunction, and consequently a lower rate of MTT reduction
    • b) The addition of cytotoxic agents will lead to metabolic dysfunction, and consequently a lower rate of MTT reduction.
  • 23
    • 77953498943 scopus 로고    scopus 로고
    • Cells to which the mimic was added remained largely similar to the control cells Although the activation by IFN-γ and LPS of cells leads to the expression of iNOS and an increased endocytic activity, co-treatment with the mimic did not lead to any significant morphological differences in comparison with cells that had been activated in the presence of IFN-γ/LPS only
    • Cells to which the mimic was added remained largely similar to the control cells. Although the activation by IFN-γ and LPS of cells leads to the expression of iNOS and an increased endocytic activity, co-treatment with the mimic did not lead to any significant morphological differences in comparison with cells that had been activated in the presence of IFN-γ/LPS only.
  • 35
    • 77953492246 scopus 로고    scopus 로고
    • - concentration
    • - concentration.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.