Using computers to identify non-compliant people at increased risk of osteoporotic fractures in general practice: A cross-sectional study

Osteoporosis International

Volumn 17, Issue 12, 2006, Pages 1808-1814

  De Lusignan, S ^a   Van Vlymen, J ^a   Hague, N ^a   Dhoul, N ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Biphosphonates; Computerised; Fractures; Medical records systems; Osteoporosis; Patient compliance; Postmenopausal; Spontaneous; Treatment refusal

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; RISEDRONIC ACID;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; COMPUTER ANALYSIS; CONTROLLED STUDY; ELECTRONICS; FEMALE; FRAGILITY FRACTURE; GENERAL PRACTICE; HIGH RISK PATIENT; HIP; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATICS; MEDICAL RECORD; NEWBORN; PATIENT COMPLIANCE; POSTMENOPAUSE; PRESCRIPTION; PREVALENCE; PRIORITY JOURNAL; SECONDARY PREVENTION; TREATMENT DURATION; VERTEBRA; WRIST;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; BONE DENSITY CONSERVATION AGENTS; CHILD; CHILD, PRESCHOOL; DIPHOSPHONATES; ENGLAND; EPIDEMIOLOGIC METHODS; FAMILY PRACTICE; FEMALE; FRACTURES, BONE; HUMANS; INFANT; MALE; MEDICAL RECORDS SYSTEMS, COMPUTERIZED; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PATIENT COMPLIANCE; SEX DISTRIBUTION;

EID: 33750204637     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-006-0188-9     Document Type: Article

References (28)

1. Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, Bauer DC, Genant HK, Haskell WL, Marcus R, Ott SM, Torner JC, Quandt SA, Reiss TF, Ensrud KE (1996) Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 348(9041):1535-1541
2. Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner T, Keller M, Chesnut CH 3rd, Brown J, Eriksen EF, Hoseyni MS, Axelrod DW, Miller PD (1999) Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomised controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. JAMA 282(14):1344-1352
3. Delmas PD, Ensrud KE, Adachi JD, Harper KD, Sarkar S, Gennari C, Reginster JY, Pols HA, Recker RR, Harris ST, Wu W, Genant HK, Black DM, Eastell R (2002) Mulitple Outcomes of Raloxifene Evaluation Investigators. Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomised clinical trial. J Clin Endocrinol Metab 87(8):3609-3617
4. Chesnut CH 3rd, Skag A, Christiansen C, Recker R, Stakkestad JA, Hoiseth A, Felsenberg D, Huss H, Gilbride J, Schimmer RC, Delmas PD (2004) Oral Ibandronate Osteoporosis Vertebral Fracture Trial in North America and Europe (BONE). Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res 19(8):1241-1249
5. Recker RR, Gallagher R, MacCosbe PE (2005) Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of women. Mayo Clin Proc 80(7):856-861
6. McCombs JS, Thiebaud P, McLaughlin-Miley C, Shi J (2004) Compliance with drug therapies for the treatment and prevention of osteoporosis. Maturitas 48(3):271-287
7. Johnell O, Kanis JA, Oden A, Johansson H, De Laet C, Delmas P, Eisman JA, Fujiwara S, Kroger H, Mellstrom D, Meunier PJ, Melton LJ 3rd, O'Neill T, Pols H, Reeve J, Silman A, Tenenhouse A (2005) Predictive value of BMD for hip and other fractures. J Bone Miner Res 20(7):1185-1194
8. Caro JJ, Ishak KJ, Huybrechts KF, Raggio G, Naujoks C (2004) The impact of compliance with osteoporosis therapy on fracture rates in actual practice. Osteoporos Int 15(12):1003-1008
9. Pols HA, Felsenberg D, Hanley DA, Stepan J, Munoz-Torres M, Wilkin TJ, Qin-sheng G, Galich AM, Vandormael K, Yates AJ, Stych B (1999) Multinational, placebo-controlled, randomised trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Foxamax International Trial Study Group. Osteoporos Int 9(5):461-468
10. Huybrechts KF, Ishak KJ, Caro JJ (2005) Assessment of compliance with osteoporosis treatment and its consequences in a managed care population. Bone Dec 1 [Epub ahead of print]
11. National Institute for Clinical Excellence (NICE) Bisphosphonates (alendronate, etidronate, risedronate), selective oestrogen receptor modulators (raloxifene) and parathyroid hormone (teriparatide) for the secondary prevention of osteoporotic fragility fractures in postmenopausal women. London; NICE Technology Appraisal 87, 2005
12. de Lusignan S, Chan T, Wood O, Hague N, Valentin T, Van Vlymen J (2005) Quality and variability of osteoporosis data in general practice computer records: implications for disease registers. Public Health. 119(9):771-780
13. Mitchell E, Sullivan F (2001) A descriptive feast but an evaluative famine: systematic review of published articles on primary care computing during 1980-1997. BMJ 322(7281):279-282
14. de Lusignan S, Valentin T, Chan T, Hague N, Wood O, van Vlymen J, Dhoul N (2004) Problems with primary care data quality: osteoporosis as an exemplar. Inform Prim Care 12(3):147-156
15. de Lusignan S, Chan T, Stevens P, O'Donoghue D, Hague N, Dzregah B, Van Vlymen J, Walker M, Hilton S (2005) Identifying patients with chronic kidney disease from general practice computer records. Fam Pract 22(3):234-241
16. de Lusignan S, Hague N, Brown A, Majeed A (2004) An educational intervention to improve data recording in the management of ischaemic heart disease in primary care. J Public Health (Oxf) 26(1):34-37
17. de Lusignan S, Chan T, Wells S, Cooper A, Harvey M, Brew S, Wright M (2003) Can patients with osteoporosis, who should benefit from implementation of the national service framework for older people, be identified from general practice computer records? A pilot study that illustrates the variability of computerised medical records and problems with searching them. Public Health 117(6):438-445
18. van Vlymen J, de Lusignan S, Hague N, Chan T, Dzregah B (2005) Ensuring the Quality of Aggregated General Practice Data: Lessons from the Primary Care Data Quality Programme (PCDQ). Stud Health Technol Inform 116:1010-1015
19. van Vlymen J, de Lusignan S. A system of metadata to control the process of query, aggregating, cleaning and analysing large datasets of primary care data. Accepted for publication. Informatics in Primary Care September 2005
20. Clinical Information Consultancy. MIQUEST (Morbidity Information Query and Export Syntax). URL: http://www.clininfo.co.uk/main/miquest.htm
21. NHS Public Health Network. Directly age-standardised rates. Downloaded from: http://www.avon.nhs.uk/phnet/methods/directly_age_standardised_rates.htm. Accessed 3rd July 2005
22. National Statistics. Population Trends 2003; 113 (Autumn): 45 (Table 1.4). Downloaded from: http://www.statistics.gov.uk/downloads/theme_population/ PT113.pdf. Accessed 3rd July 2005
23. Sanders KM, Nicholson GC, Watts JJ, Pasco JA, Henry MJ, Kotowicz MA, Seeman E (2006) Half the burden of fragility fractures in the community occur in women without osteoporosis. When is fracture prevention cost-effective? Bone 38(5):694-700
24. Krueger KP, Felkey BG, Berger BA (2003) Improving adherence and persistence: a review and assessment of interventions and description of steps toward a national adherence initiative. J Am Pharm Assoc 43(6):668-678
25. Richter A, Anton SE, Koch P, Dennett SL (2003) The impact of reducing dose frequency on health outcomes. Clin Ther 25(8):2307-2335
26. Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761-1767
27. Holt G, Khaw KT, Reid DM, Compston JE, Bhalla A, Woolf AD, Crabtree NJ, Dalzell N, Wardley-Smith B, Lunt M, Reeve J (2002) Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry. Br J Radiol 75 (897):736-742
28. Vik SA, Maxwell CJ, Hanley DA (2005) Treatment of osteoporosis in an older home care population. BMC Musculoskelet Disord 6(1):7