Efficacy and safety of lamotrigine in lennox-Gastaut syndrome

Iranian Journal of Child Neurology

Volumn 3, Issue 3, 2009, Pages 33-38

  Fallah, R ^a   Akhavan, Karbasi S ^a   Golestan, M ^a  

^a SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Epilepsy; Lamotrigine; Lennox Gastaut syndrome (LGS); Refractory epilepsy

Indexed keywords

LAMOTRIGINE; VALPROIC ACID;

ADOLESCENT; ARTICLE; ATAXIA; ATONIC SEIZURE; BLOOD TOXICITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DROWSINESS; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; GRAND MAL SEIZURE; HUMAN; INTRACTABLE EPILEPSY; LENNOX GASTAUT SYNDROME; LIVER TOXICITY; MALE; NEPHROTOXICITY; PRESCHOOL CHILD; SCHOOL CHILD; SEIZURE; TONIC CLONIC SEIZURE; TONIC SEIZURE;

EID: 77953452377     PISSN: 17354668     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Trevathan, E. Infantile Spasms and Lennox-Gastaut Syndrome. J Child Neurol 2002; 17: 9-22.
2. Arzimanoglou A, French J, Blume WT, Cross JH, Ernst JP, Feucht M, et al. Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. Lancet Neurol 2009;8(1):82-93.
3. Shields WD. Diagnosis of Infantile Spasms, Lennox-Gastaut Syndrome, and Progressive Myoclonic Epilepsy. Epilepsia 2004;45:2-4.
4. Koh S, Sankar R, Wu J, Menkes JH. Paroxysmal disorders. In: Menkes JH, Sarnat HB, Maria BL(eds): Child neurology. 7 th edition. Philadelphia: Lippincott Williams & Wilkins; 2006. P.874-877.
5. Holes GL. Generalized seizures. Swaiman KF, Ashwal S, Ferriero D M. Pediatric Neurology: principles & practice. 4th ed. Philadelphia:Mosby Elsevier;2006. P.1031-1033.
6. Hancock, E, Cross, H. Treatment of Lennox-Gastaut syndrome. Cochrane Database Syst Rev 2003;CD003277.
7. Markand ON. Lennox-Gastaut syndrome (childhood epileptic encephalopathy). J Clin Neurophysiol 2003;20: 426-441.
8. Abu Saleh T, Stephen L. Lennox gastaut syndrome, review of the literature and a case report. Head Face Med 2008; 9(4):9-14.
9. Cukiert A, Burattini JA, Mariani PP. Extended, one-stage callosal section for treatment of refractory secondarily generalized epilepsy in patients with Lennox-Gastaut and Lennox-like syndromes. Epilepsia 2006; 47:371.
10. Wheless JW, Clarke DF, Arzimanoglou A, Carpenter D. Treatment of pediatric epilepsy: European expert opinion 2007. Epileptic Disord 2007; 9(4):353-412.
11. Malphrus AD, Wilfong AA. Use of the newer antiep-ileptic drugs in pediatric epilepsies. Curr Treat Options Neurol 2007;9(4):256-267
12. Ren LK, Wu LW, Jin LR, Gao W, Shao XQ. Characteristics of clinical manifestations and EEG of Lennox-Gastaut syndrome. Zhonghua Er Ke Za Zhi 2003;41(1):7-10.
13. Malik S, Arif H, Hirsch LJ. Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. Expert Rev Neurother 2006;6(11):1609-1627
14. Duric M. Therapies for Lennox-Gastaut syndrome. Srp Arh Celok Lek 2005;133(5-6):283-287
15. Mc Donald DG, Najam Y, Keegan MB, Whooley M, Madden D, McMenamin JB. The use of lamotrigine, vigabatrin and gabapentin as add-on therapy in intractable epilepsy of childhood. Seizure 2005;14(2):112-116
16. Conry JA. Pharmacologic treatment of the catastrophic epilepsies. Epilepsia 2004;45(Suppl.5):12-16
17. Sinclair DB. Prednisone therapy in pediatric epilepsy. Pediatr Neurol 2003;28(3):194-198
18. Lee CY, Fu WM, Chen CC, Su MJ, Liou HH. Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus. Epilepsia 2008;49(5):888-897
19. French JA, Kanner AM, Bautista J. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62:1252.
20. Stephani U. The natural history of myoclonic astatic epilepsy (Doose syndrome) and Lennox-Gastaut syndrome. Epilepsia 2006;47:53-55.
21. Barzagar M, Tonekaboni SH, Ghofrani M. Lamotrigine as add-on therapy in children with drug-resistant epilepsy (Iranian-experience. MJIRI 2003;17(1):15-18.
22. Schlumberger E, Chavez F, Palacios L, Rey E, Pajot N, Dulac O. Lamotrigine in treatment of 120 children with epilepsy. Epilepsia 1994;35:359-367.
23. Timmings Pl, Richens A. Lamotrigine as add-on drug in the management of Lennox-Gastaut syndrome. Eur Neurol 1992; 32: 305-307.
24. Motte J, Trevathan E, Arvidsson JFV, Barrera MN,
25. Mulencs EL, Manasco P. et al. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. N Engl J Med 1997;337(25):1807-1812
26. Chen SJ, Chang KP, Wong TT, Kwan SY, Hsu ML, Wang CC. Lamotrigine adjunctive therapy in children with refractory epilepsy: a medical center study. Acta Paediatr Taiwan 2006;47(3):123-126
27. Biton V, Sackellares JC, Vuong A, Hammer AE, Barrett PS, Messenheimer JA. Double-blind, placebo-controlled study of lamotrigine in primary generalized tonic-clonic seizures. Neurology 2005 13;65(11):1737-1743
28. Johnson M V. Seizure in childhood. Behrman RE, Kliegman RM, Jenson HB. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Saunders; 2007. P.2457.
29. Alvestad S, Lydersen S, Brodtkorb E. Cross-reactivity pattern of rash from current aromatic antiepileptic drugs. Epilepsy Res 2008;80(2-3):194-200.
30. Naritoku DK, Warnock CR, Messenheimer JA, Borgohain R, Evers S, Guekht AB, et al. Lamotrigine extended-release as adjunctive therapy for partial seizures. Neurology 2007 16;69(16):1610-1618
31. Mauri-Llerda JA, Morales-Martinez MD, Salas-Puig J, Vadillo-Olmo FJ, Campos D, Diaz MC, et al. A retrospective study of the effectiveness of lamotrigine in monotherapy for the treatment of epileptic seizures. [The ERELMO study].Rev Neurol 2008;16-29; 46(4):197-202.
32. Bootsma HP, Vos AM, Hulsman J, Lambrechts D, Leenen L, Majoie M, et al. Lamotrigine in clinical practice: long-term experience in patients with refractory epilepsy referred to a tertiary epilepsy center. Epilepsy Behav 2008;12(2):262-268
33. Baumann RJ, Fakhoury TA, Kustra RP, Vuong A, Hammer AE, Messenheimer JA. Conversion to lamotrigine monotherapy from valproate monotherapy in older adolescent patients with epilepsy. Curr Med Res Opin 2007;23(10):2461-2465