In vitro platelet aggregation inhibitory effect of triterpenoid compound from the leaf of Elephantopus scaber Linn

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 2, Issue 2, 2010, Pages 49-51

  Sankaranarayanan, S ^b   Bama, P ^a   Ramachandran, J ^b   Jayasimman, R ^b   Kalaichelvan, P T ^c   Deccaraman, M ^a   Vijayalakshimi, M ^a   Visveswaran, M ^b   Chitibabu, C V ^d  

^a DR M G R EDUCATIONAL AND RESEARCH INSTITUTE   (India)

^b Gloris BioMed Research Centre P Ltd   (India)

^c UNIVERSITY OF MADRAS   (India)

^d Department of Botany   (India)

Author keywords

Antiplatelet activity; Elephantopus scaber Linn; Lupeol; Platelet aggregation; Triterpenoid

Indexed keywords

LUPEOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRITERPENOID;

ANIMAL CELL; ARTICLE; ASTERACEAE; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ISOLATION; ELEPHANTOPUS SCABER; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MALE; NONHUMAN; PLANT LEAF; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; THIN LAYER CHROMATOGRAPHY; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS PREVENTION;

EID: 77953427762     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Lin CC and Yen MH. J. chin. Med 1992; (Taipei) 2: pp. 33.
2. Peer LM, and Metzger J. Medicinal plant of East and Southeast Asia: Attributed properties and uses. The MII press, London. 1980; pp. 92.
3. Hoehne FC. Plantas e substancias vegetais tdxicas e medicinais. Graphicars, Sgo Paulo, 1939; 299.
4. De silva, LB, Herath WHMW, Jennings RC, Mahendrani M, and Wannigama GE. A new sesquiterpene lactone from. Elephantopus scaber. Phytochemistry. 1982; 21(5):1173-l 175.
5. Rand ML, Leung R, and Packham MA. Platelet function assays. Transfus. Apher. Sci. 2003; 28: 307-317.
6. Steinhubl SR. and Moliterno DJ. The role of the platelet in the pathogenesis of atherothrombosis. Am. J. Cardiovasc. Drug. 2005; 5: 399-408.
7. Moake JL, Kroll MH, Hellums JD, McIntire LV, and Schafer AI. Platelets and shear stress. Blood. 1996; 88:1525-1541.
8. Papkoff J, Chen RH, Blenis J, Forsman J. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol. Cell. Biol. 1994; 14: 463-472.
9. Waller GR. Biochemical Applications of Mass Spectroscopy. John Wiley and Sons, 1980; 396.
10. Monaco P. and Previteva L. Isoprenoids from the leaves of Quercus suber, J. Nat. Prod. 1984; 47: 673-676.
11. Reynolds WF, McLean S, Poblawski J, Enriquez RG, Esobar LI and Leon I. Total Assignment of 13C and 1H spectra of three isomeric triterperiol derivatives by 2D NMR: An investigation of the potential utility of 1H chemical shifts in structural investigations Tetrahedron. 1986; 42: 3419.
12. Yong Yook Lee, Sanghyun Lee, Jin ling Jin, Hyw sook yunhoi. Platelet Anti-Aregatary effect of Coumarins from the root of Anelia genuflexa and A.Gigas. Arh Pharm Res. 2003; 26(9): 723-726.
13. Sung kwon ko, Soun mok lee, Won kyunnwhary. Antiplatelet Aggregation activity of Stilbene derivatives from Rhnum undulatum. Arch Pharm Res. 1999; 22(4). 401-403.
14. Heemskerk JWM, Feijge MAH, Rietman E, Hornstra G. Rat platelets are deficient in internal Ca2+release and require influx of extracellular Ca2+for activation. FEBS Lett. 1991; 284: 223-226.
15. Rosado JA, Sage SO, Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. J. Biol. Chem. 2001; 276: 15659-15665.
16. Lee JY, Lee MY, Chung SM, and Chung JH. Chemically induced platelet lysis causes vasoconstriction by release of serotonin. Toxicol. Appl. Pharmacol. 1998; 149: 235-242.