Cost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumatic brain injury

ClinicoEconomics and Outcomes Research

Volumn 2, Issue 1, 2010, Pages 15-23

  Kazerooni, Rashid ^a   Bounthavong, Mark ^a,b  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Cost effectiveness; Levetiracetam; Neurosurgery; Phenytoin; Seizure prophylaxis; Traumatic brain injury (TBI)

Indexed keywords

CARBAMAZEPINE; ETIRACETAM; FOSPHENYTOIN SODIUM; PHENYTOIN;

ARTICLE; ATTITUDE TO HEALTH; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; DRUG COST; DRUG DOSE INCREASE; HEALTH CARE COST; HUMAN; LOADING DRUG DOSE; NEUROSURGERY; OUTCOME ASSESSMENT; SEIZURE; TRAUMATIC BRAIN INJURY; TREATMENT DURATION;

EID: 77953391621     PISSN: None     EISSN: 11786981     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Deutschman CS, Haines SJ. Anticonvulsant prophylaxis in neurosurgery. Neurosurgery. 1985;17(3):510-517.
2. Mananka S, Ishijima B, Mayanagi Y. Postoperative seizures: epidemiology, pathology, and prophylaxis. Neurol Med Chir (Tokyo). 2003; 43(12):589-600.
3. North JB, Penhall RK, Hanieh A, Frewin DB, Taylor WB. Phenytoin and postoperative epilepsy: a double-blind study. J Neurosurg. 1983; 58(5):672-677.
4. Shaw MD, Foy PM. Epilepsy after craniotomy and the place of prophylactic anticonvulsant drugs: discussion paper. J R Soc Med. 1991;84(4):221-223.
5. Foy PM, Copeland GP, Shaw MD. The natural history of post operative seizures. Acta Neurochir (Wien). 1981;57(1-2):15-22.
6. Temkin NR. Risk factors for posttraumatic seizures in adults. Epilepsia. 2003;44(Suppl 10):18-20.
7. Frey LC. Epidemiology of posttraumatic epilepsy: a critical review. Epilepsia. 2003;44(Suppl 10):11-17.
8. Lee ST, Lui TN. Early seizures after mild closed head injury. J Neurosurg. 1992;76(3):435.
9. Chang BS, Lowenstein DH. Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2003;60(1):10-16.
10. Schierhout G, Roberts I. Anti-epileptic drugs for preventing seizures following acute traumatic brain injury. Cochrane Database Syst Rev. 2001;(4):CD000173.
11. Agrawal A, Timothy J, Pandit L, Manju M. Post-traumatic epilepsy: an overview. Clin Neurol Neurosurg. 2006;108(5):433-439.
12. th American Association of Neurological Surgeons Annual Meeting; 2001 April 21-26; Toronto, Ontario, Canada.
13. Temkin NR. Prophylactic anticonvulsants after neurosurgery. Epilepsy Curr. 2002;2(4):105-107.
14. Phenytoin drug information. www.uptodateonline.com. Accessed July 23, 2009.
15. Allen J, Ludden T, Burrow S, Clementi W, Stavchansky S. Phenytoin accumulation kinetics. Clin Pharmacol Ther. 1979;26(4): 445-448.
16. Scheinfeld N. Impact of phenytoin therapy on the skin and skin disease. Expert Opin Drug Saf. 2004;3(6):655-665.
17. Temkin NR. Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. Epilepsia. 2001;42(4):515-524.
18. Glötzner FL, Haubitz I, Miltner F, Kapp G, Pflughaupt KW. Anfallsprophylaxe mit Carbamazepin nach schweren Schädelhirnverletzungen. Neurochirurgia. 1983;26(3):66-79.
19. Holland JP, Stapleton SR, Moore AJ, Marsh HT, Uttley D, Bell BA. A randomized double blind study of sodium valproate for the prevention of seizures in neurosurgical patients. Proceedings of the 125th Meeting of the Society of British Neurological Surgeons; 1994 September 7-9; University of Dundee, Scotland, UK.
20. Franceschetti S, Binelli S, Casazza M, et al. Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours. Acta Neurochir. 1990;103(1-2):47-51.
21. Milligan T, Hurwitz S, Bromfield E. Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. Neurology. 2008;71(9):665-669.
22. Jones K, Puccio A, Harshman K, et al. Levetiracetam versus phenytoin for seizure prophylaxis in traumatic brain injury. Neurosurg Focus. 2008;25(4):E3.
23. Szaflarski JP, Sangha KS, Lindsell CJ, Shutter LA. Prospective, randomized, single-blinded comparative trial of intravenous levetiracetam versus phenytoin for seizure prophylaxis. Neurocrit Care. 2009 Nov 7. [Epub ahead of print].
24. Swadron SP, Rudis MI, Azimian K, Beringer P, Fort D, Orlinsky M. A comparison of phenytoin-loading techniques in the emergency department. Acad Emerg Med. 2004;11(3):244-252.
25. Fleming T, ed. Redbook: Pharmacy's Fundamental Reference. Montvale, NJ: Thomson PDR; 2008
26. Briggs A, Sculpher M, Claxton K. Decision Modeling for Health Economic Evaluation. Oxford: Oxford University Press; 2006.
27. Petitti DB. Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine. 2nd edition. USA: Oxford University Press; 2000.
28. Shaw JW, Zachry WM. Application of probabilistic sensitivity analysis in DA modeling. Formulary. 2002;37(1):32-340
29. Fenwick E, O'Brien BJ, Briggs A. Cost-effectiveness acceptability curves - facts, fallacies, and frequently asked questions. Health Econ. 2004;13(5):405-415.
30. Fenwick E, Byford S. A guide to cost-effectiveness acceptability curves. Br J Psychiatry. 2005;187:106-108.
31. Briggs A, Fenn P. Confidence intervals or surfaces? Uncertainty on the cost-effectiveness plane. Health Econ. 1998;7(8):723-740.
32. Pagni CA, Zenga F. Posttraumatic epilepsy with special emphasis on prophylaxis and prevention. Acta Neurochir Suppl. 2005;93:27-34.
33. Annegers JF, Hauser WA, Coan SP, Rocca A. A population-based study of seizures after traumatic brain injuries. N Engl J Med. 1998; 338(1):20-24.