Embryotoxic effects of the marine biotoxin okadaic acid on murine embryonic stem cells

Toxicon

Volumn 55, Issue 4, 2010, Pages 855-863

  Ehlers, Anke ^a   Stempin, Sandra ^a   Al Hamwi, Regina ^a   Lampen, Alfonso ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Development; Embryotoxicity; EST; F9 reporter gene assay; Marine toxins; Okadaic acid

Indexed keywords

MARINE TOXIN; OKADAIC ACID;

ANIMAL CELL; ARTICLE; BIOASSAY; CELL ASSAY; CELL CONTACT; CELL DIFFERENTIATION; CELL SHAPE; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; EMBRYOID BODY; EMBRYONIC STEM CELL; EMBRYOTOXICITY; GENETIC TRANSFECTION; HEART MUSCLE CELL; IMPEDANCE; IN VITRO STUDY; LUMINESCENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPORTER GENE; TERATOGENICITY; ANIMAL; ANIMAL EMBRYO; DRUG EFFECT;

BIVALVIA; DINOPHYCEAE; MOLLUSCA; MURINAE;

ANIMALS; CELL DIFFERENTIATION; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; GENES, REPORTER; MARINE TOXINS; MICE; OKADAIC ACID;

EID: 77953380880     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.12.008     Document Type: Article

References (26)

1. Casarini L., Franchini A., Malagoli D., Ottaviani E. Evaluation of the effects of the marine toxin okadaic acid by using FETAX assay. Toxicol. Lett. 2007, 169:145-151.
2. Dawson J.F., Holmes C.F. Molecular mechanisms underlying inhibition of protein phosphatases by marine toxins. Front. Biosci. 1999, 4:646-658.
3. EFSA (European Food Safety Authority) Marine biotoxins in shellfish-okadaic acid and analogues-scientific opinion of the panel on contaminants in the food chain. EFSA J. 2008, 589:1-62.
4. Genschow E., Spielmann H., Scholz G., Pohl I., Seiler A., Clemann N., Bremer S., Becker K. Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests. Altern. Lab. Anim. 2004, 32:209-244.
5. Genschow E., Spielmann H., Scholz G., Seiler A., Brown N., Piersma A., Brady M., Clemann N., Huuskonen H., Paillard F., Bremer S., Becker K. The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods. Altern. Lab. Anim. 2002, 30:151-176.
6. Hogan B.L.M., Barlow D., Tilly R. F9 teratocarcinoma cells as a model for the differentiation of parietal and visceral endoderm in the mouse. Cancer Surv. 1983, 2:115-140.
7. Honkanen R.E., Codispoti B.A., Tse K., Boynton A.L., Honkanan R.E. Characterization of natural toxins with inhibitory activity against serine/threonine protein phosphatases. Toxicon 1994, 32:339-350.
8. Ito E., Yasumoto T., Takai A., Imanishi S., Harada K. Investigation of the distribution and excretion of okadaic acid in mice using immunostaining method. Toxicon 2002, 40:159-165.
9. Lampen A., Carlberg C., Nau H. Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives. Eur. J. Pharmacol. 2001, 431:25-33.
10. Lampen A., Grimaldi P.A., Nau H. Modulation of peroxisome proliferator-activated receptor delta activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation. Mol. Pharmacol. 2005, 68:193-203.
11. Lampen A., Siehler S., Ellerbeck U., Gottlicher M., Nau H. New molecular bioassays for the estimation of the teratogenic potency of valproic acid derivatives in vitro: activation of the peroxisomal proliferator-activated receptor (PPARdelta). Toxicol. Appl. Pharmacol. 1999, 160:238-249.
12. Le Hegarat L., Jacquin A.G., Bazin E., Fessard V. Genotoxicity of the marine toxin okadaic acid, in human caco-2 cells and in mice gut cells. Environ. Toxicol. 2006, 21:55-64.
13. Leira F., Alvarez C., Vieites J.M., Vieytes M.R., Botana L.M. Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay. Toxicol. Vitro 2001, 15:277-282.
14. Leira F., Alvarez C., Vieites J.M., Vieytes M.R., Botana L.M. Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line. Toxicol. Vitro 2002, 16:23-31.
15. Malaguti C., Rossini G.P. Recovery of cellular E-cadherin precedes replenishment of estrogen receptor and estrogen-dependent proliferation of breast cancer cells rescued from a death stimulus. J. Cell. Physiol. 2002, 192:171-181.
16. Matias W.G., Creppy E.E. Transplacental passage of [3H]-okadaic acid in pregnant mice measured by radioactivity and high-performance liquid chromatography. Hum. Exp. Toxicol. 1996, 15:226-230.
17. Matias W.G., Traore A., Creppy E.E. Variations in the distribution of okadaic acid in organs and biological fluids of mice related to diarrhoeic syndrome. Hum. Exp. Toxicol. 1999, 18:345-350.
18. Nishina Y., Sumi T., Iwai S.A., Nishimune Y. Effects of protein phosphatase inhibition by okadaic acid on the differentiation of F9 embryonal carcinoma cells. Exp. Cell Res. 1995, 217:288-293.
19. zur Nieden N.I., Kempka G., Ahr H.J. Molecular multiple endpoint embryonic stem cell test - a possible approach to test for the teratogenic potential of compounds. Toxicol. Appl. Pharmacol. 2004, 194:257-269.
20. Rohwedel J., Guan K., Wobus A.M. Induction of cellular differentiation by retinoic acid in vitro. Cells Tissues Organs 1999, 165:190-202.
21. Seiler A.E., Buesen R., Visan A., Spielmann H. Use of murine embryonic stem cells in embryotoxicity assays: the embryonic stem cell test. Methods Mol. Biol. 2006, 329:371-395.
22. Sleigh M.J. Differential regulation of viral and cellular genes in F9 mouse embryonal carcinoma cells. Nucleic Acids Res. 1987, 15:9379-9395.
23. Sleigh M.J. Gene expression and differentiation in F9 mouse embryonal carcinoma cells. Biochem. Soc. Symp. 1989, 55:1-12.
24. Spielmann H., Genschow E., Scholz G., Brown N.A., Piersma A.H., Brady M., Clemann N., Huuskonen H., Paillard F., Bremer S., Becker K. Preliminary results of the ECVAM validation study on three in vitro embryotoxicity tests. Altern. Lab. Anim. 2001, 29:301-303.
25. Takai A., Bialojan C., Troschka M., Ruegg J.C. Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin. FEBS Lett. 1987, 217:81-84.
26. Tubaro A., Sosa S., Carbonatto M., Altinier G., Vita F., Melato M., Satake M., Yasumoto T. Oral and intraperitoneal acute toxicity studies of yessotoxin and homoyessotoxins in mice. Toxicon 2003, 41:783-792.