A role of CREB in BRCA1 constitutive promoter activity and aromatase basal expression

International Journal of Biomedical Science

Volumn 4, Issue 4, 2008, Pages 260-265

  Ghosh, Sagar ^a   Lu, Yunzhe ^a   Hu, Yanfen ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

Aromatase; BRCA1; CREB

Indexed keywords

AROMATASE; BRCA1 PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE;

ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME REGULATION; ESTROGEN SYNTHESIS; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; GRANULOSA CELL; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REPORTER GENE;

EID: 77953378222     PISSN: 15509702     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Simpson, E.R., et al., Aromatase-a brief overview. Annu. Rev. Physiol. 2002; 64: 93-127.
2. Sasano, H. and N. Harada, Intratumoral aromatase in human breast, endometrial, and ovarian malignacies. Endocrine Rev., 1998; 19: 583-607.
3. Richards, J.S., Hormonal Control of Gene Expression in the Ovary. Endo. Reviews. 1994; 15: 725-751.
4. Nishi, Y., et al., Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulation hormone receptor. Endocrinol. 2001; 142: 437-445.
5. Aiyar, S.E., et al., Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes & Dev. 2004; 18: 2134-2146.
6. Ghosh, S., et al., Jun proteins modulate the ovary-specific promoter of aromatase gene in ovarian granulosa cells via a cAMP-responsive element. Oncogene. 2005; 24: 2236-2246.
7. Ghosh, S., et al., Tumor suppressor BRCA1 inhibits a breast cancer associated promoter of the aromatase gene (CYP19) in human adipose stromal cells. Am. J. Physiol. Endocrinol. Metab. 2007; 292: E246-52.
8. Hu, Y., et al., Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression. Oncogene, 2005. in press.
9. Lu, Y., et al., Ubiquitination and Proteasome-Mediated Degradation of BRCA1 and BARD1 during Steroidogenesis in Human Ovarian Granulosa Cells. Mol. Endocrinol. 2007; 21(3): 651-663.
10. Atlas, E., M. Stramwasser, and C. Mueller, A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element. Oncogene. 2001; 20:7110-7114.
11. Conkright, M.D., et al., Genome-Wide Analysis of CREB Target Genes Reveals A Core Promoter Requirement for cAMP Responsiveness. Mol. Cell. 2003; 11:1101-1108.
12. Impey, S., et al., Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell. 2004; 119(7):1041-1054.
13. Zhang, X.K., et al., Genome-Wide analysis of cAMP-responsive element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA. 2005; 102(12):4459-4464.
14. Maruyama, K., et al., The NGFI-B subfamily of the nuclear receptor superfamily (Review). Int. J. Oncol. 1998; 12:1237-1243.
15. Herschman, H.R., Primary response genes induced by growth factors and tumor promoters. Annu Rev. Biochem. 1991; 60:281-319.
16. Wu, Y., et al., The orphan nuclear receptors NURR1 and NGFI-B modulate aromatase gene expression in ovarian granulosa cells: a possible mechanism for repression of aromatase expression upon luteinizing hormone surge. Endocrinology. 2005; 146(1):237-46.