Urethane inhibits genioglossal long-term facilitation in un-paralyzed anesthetized rats

Neuroscience Letters

Volumn 477, Issue 3, 2010, Pages 124-128

  Cao, Ying ^a   Ling, Liming ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Genioglossus muscle; Intermittent hypoxia; Long term facilitation; Paralysis; Respiratory control; Urethane

Indexed keywords

ALFAXALONE; CHLORALOSE; OXYGEN; URETHAN;

ACUTE INTERMITTENT HYPOXIA; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BREATHING MUSCLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE REDUCTION; DRUG MECHANISM; ELECTROMYOGRAPHY; GENIOGLOSSAL MUSCLE; HYPEROXIA; HYPOXIA; LONG TERM POTENTIATION; MALE; MUSCLE CONTRACTION; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; VAGOTOMY;

ANESTHETICS, INTRAVENOUS; ANIMALS; ANOXIA; ELECTROMYOGRAPHY; MALE; PARALYSIS; PHARYNGEAL MUSCLES; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION, ARTIFICIAL; RESPIRATORY PHYSIOLOGICAL PROCESSES; URETHANE;

EID: 77953357316     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.04.047     Document Type: Article

References (24)

1. Aboubakr S.E., Taylor A., Ford R., Siddiqi S., Badr M.S. Long-term facilitation in obstructive sleep apnea patients during NREM sleep. J. Appl. Physiol. 2001, 91:2751-2757.
2. Babcock M.A., Badr M.S. Long-term facilitation of ventilation in humans during NREM sleep. Sleep 1998, 21:709-716.
3. Bach K.B., Mitchell G.S. Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent. Respir. Physiol. 1996, 104:251-260.
4. Bocchiaro C.M., Feldman J.L. Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:4292-4295.
5. Y. Cao, C. Liu, L. Ling., Acute intermittent hypoxia-induced decrease in pharyngeal collapsibility requires 5-HT2 and NMDA receptors in rats. (Abstract) Program Number: 799.11. The Experimental Biology Annual Meeting (2010).
6. Chowdhuri S., Pierchala L., Aboubakr S.E., Shkoukani M., Badr M.S. Long-term facilitation of genioglossus activity is present in normal humans during NREM sleep. Respir. Physiol. Neurobiol. 2008, 160:65-75.
7. Hara K., Harris R.A. The anesthetic mechanism of urethane: the effects on neurotransmitter-gated ion channels. Anesth. Analg. 2002, 94:313-318.
8. Janssen P.L., Fregosi R.F. No evidence for long-term facilitation after episodic hypoxia in spontaneously breathing, anesthetized rats. J. Appl. Physiol. 2000, 89:1345-1351.
9. Ling L. Serotonin and NMDA receptors in respiratory long-term facilitation. Respir. Physiol. Neurobiol. 2008, 164:233-241.
10. Ling L., Fuller D.D., Bach K.B., Kinkead R., Olson E.B., Mitchell G.S. Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing. J. Neurosci. 2001, 21:5381-5388.
11. Maggi C.A., Meli A. Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1. General considerations. Experientia 1986, 42:109-114.
12. Mahamed S., Mitchell G.S. Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?. Exp. Physiol. 2007, 92:27-37.
13. Mateika J.H., Fregosi R.F. Long-term facilitation of upper airway muscle activities in vagotomized and vagally intact cats. J. Appl. Physiol. 1997, 82:419-425.
14. Mateika J.H., Narwani G. Intermittent hypoxia and respiratory plasticity in humans and other animals: does exposure to intermittent hypoxia promote or mitigate sleep apnoea?. Exp. Physiol. 2009, 94:279-296.
15. McGuire M., Ling L. Pharyngeal airway collapsibility progressively decreases for about 1 hour following acute intermittent hypoxia in rats. Sleep Med. 2006, 7:S5-S6.
16. McGuire M., Zhang Y., White D.P., Ling L. Effect of hypoxic episode number and severity on ventilatory long-term facilitation in awake rats. J. Appl. Physiol. 2002, 93:2155-2161.
17. McGuire M., Zhang Y., White D.P., Ling L. Phrenic long-term facilitation requires NMDA receptors in the phrenic motonucleus in rats. J. Physiol. 2005, 567:599-611.
18. McKay L.C., Janczewski W.A., Feldman J.L. Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats. J. Physiol. 2004, 557:13-18.
19. Millhorn D.E., Eldridge F.L., Waldrop T.G. Prolonged stimulation of respiration by a new central neural mechanism. Respir. Physiol. 1980, 41:87-103.
20. Mitchell G.S., Baker T.L., Nanda S.A., Fuller D.D., Zabka A.G., Hodgeman B.A., Bavis R.W., Mack K.J., Olson E.B. Invited review: intermittent hypoxia and respiratory plasticity. J. Appl. Physiol. 2001, 90:2466-2475.
21. Ryan S., Nolan P. Episodic hypoxia induces long-term facilitation of upper airway muscle activity in spontaneously breathing anaesthetized rats. J. Physiol. 2009, 587:3329-3342.
22. Sokolowska B., Pokorski M. Ventilatory augmentation by acute intermittent hypoxia in the rabbit. J. Physiol. Pharmacol. 2006, 57(Suppl. 4):341-347.
23. White D.P. Long-term facilitation (LTF) and obstructive sleep apnea. Respir. Physiol. Neurobiol. 2007, 158:112-113.
24. Zhang Y., McGuire M., White D.P., Ling L. Episodic phrenic-inhibitory vagus nerve stimulation paradoxically induces phrenic long-term facilitation in rats. J. Physiol. 2003, 551:981-991.