Association of the genetic polymorphisms of the ACE gene and the eNOS gene with lupus nephropathy in northern Chinese population

BMC Medical Genetics

Volumn 11, Issue 1, 2010, Pages

  Li, X ^a   An, J ^b   Guo, R ^c   Jin, Z ^d   Li, Y ^e   Zhao, Y ^a,f   Lu, F ^g   Lian, H ^c   Liu, P ^b   Jin, X ^b  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c Chinese medical hospital of Weihai city   (China)

^d MUDANJIANG MEDICAL UNIVERSITY   (China)

^e HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^f THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^g BAOTOU MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GENOMIC DNA; GUANINE; THYMINE; NOS3 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; ADULT; AGE; ARTICLE; CHINESE; CONTROLLED STUDY; DNA EXTRACTION; ETHNIC DIFFERENCE; EXON; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; LEUKOCYTE; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; POPULATION GENETICS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; ALLELE; ASIAN; DISEASE COURSE; ETHNIC AND RACIAL GROUPS; GENETICS;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; DISEASE PROGRESSION; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; NITRIC OXIDE SYNTHASE TYPE III; PEPTIDYL-DIPEPTIDASE A; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; POPULATION GROUPS;

EID: 77953338220     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-11-94     Document Type: Article

References (46)

1. Sprovieri SR, Sens YA. Polymorphisms of the renin-angiotensin system genes in Brazilian patients with lupus nephropathy. Lupus 2005, 14:356-362. 10.1191/0961203305lu2093oa, 15934435.
2. Uhm WS, Lee HS, Chung YH, Kim TH, Bae SC, Joo KB, Kim TY, Yoo DH. Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE. Lupus 2002, 11:227-233. 10.1191/0961203302lu174oa, 12043886.
3. Tan FK, Arnett FC. The genetics of lupus. Curr Opin Rheumatol 1998, 10:399-408. 10.1097/00002281-199809000-00002, 9746854.
4. Gudmundsson S, Steinsson K. Systemic lupus erythematosus in Iceland 1975 through 1984. A nationwide epidemiological study in an unselected population. J Rheumatol 1990, 17:1162-1167.
5. Schelling JR, Zarif L, Sehgal A, Iyengar S, Sedor JR. Genetic susceptibility to end-stage renal disease. Curr Opin Nephrol Hypertens 1999, 8:465-472. 10.1097/00041552-199907000-00011, 10491742.
6. Freedman BI, Wilson CH, Spray BJ, Tuttle AB, Olorenshaw IM, Kammer GM. Familial clustering of end-stage renal disease in blacks with lupus nephritis. Am J Kidney Dis 1997, 29:729-732. 10.1016/S0272-6386(97)90126-8, 9159307.
7. Harley JB, Moser KL, Gaffney PM, Behrens TW. The genetics of human systemic lupus erythematosus. Curr Opin Immunol 1998, 10:690-696. 10.1016/S0952-7915(98)80090-3, 9914226.
8. Parsa A, Peden E, Lum RF, Seligman VA, Olson JL, Li H, Seldin MF, Criswell LA. Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families. Genes Immun 2002, (3 Suppl 1):S42-46. 10.1038/sj.gene.6363907, 12215901.
9. Kaufman KM, Kelly J, Gray-McGuire C, Asundi N, Yu H, Reid J, Baird T, Hutchings D, Bruner G, Scofield RH, et al. Linkage analysis of angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and systemic lupus erythematosus. Mol Cell Endocrinol 2001, 177:81-85. 10.1016/S0303-7207(01)00424-5, 11377823.
10. Serrano NC, Paez C, Correa PA, Anaya JM. Endothelial nitric oxide synthase gene polymorphism is associated with systemic lupus erythematosus. J Rheumatol 2004, 31:2163-2168.
11. Kim S, Iwao H. Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev 2000, 52:11-34.
12. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel JM. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet 1992, 1:72-75. 10.1038/ng0492-72, 1338766.
13. Huang J, Yang Y, Li L. Study of relationship between ACE gene I/D polymorphism and renal predisposition in SLE. J Clinical Internal Medcine 1999, 16:205-206.
14. Schena FP, D'Altri C, Cerullo G, Manno C, Gesualdo L. ACE gene polymorphism and IgA nephropathy: an ethnically homogeneous study and a meta-analysis. Kidney Int 2001, 60:732-740. 10.1046/j.1523-1755.2001.060002732.x, 11473656.
15. Gutierrez C, Vendrell J, Pastor R, Llor C, Aguilar C, Broch M, Richart C. Angiotensin I-converting enzyme and angiotensinogen gene polymorphisms in non-insulin-dependent diabetes mellitus. Lack of relationship with diabetic nephropathy and retinopathy in a Caucasian Mediterranean population. Metabolism 1997, 46:976-980. 10.1016/S0026-0495(97)90090-1, 9258285.
16. Narita I, Goto S, Saito N, Song J, Omori K, Kondo D, Sakatsume M, Gejyo F. Renoprotective efficacy of renin-angiotensin inhibitors in IgA nephropathy is influenced by ACE A2350G polymorphism. J Med Genet 2003, 40:e130. 10.1136/jmg.40.12.e130, 1735349, 14684698.
17. Wanchu A, Khullar M, Deodhar SD, Bambery P, Sud A. Nitric oxide synthesis is increased in patients with systemic lupus erythematosus. Rheumatol Int 1998, 18:41-43. 10.1007/s002960050055, 9782531.
18. Lapointe J, Roy M, St-Pierre I, Kimmins S, Gauvreau D, MacLaren LA, Bilodeau JF. Hormonal and spatial regulation of nitric oxide synthases (NOS) (neuronal NOS, inducible NOS, and endothelial NOS) in the oviducts. Endocrinology 2006, 147:5600-5610. 10.1210/en.2005-1548, 16935840.
19. Marsden PA, Heng HH, Scherer SW, Stewart RJ, Hall AV, Shi XM, Tsui LC, Schappert KT. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 1993, 268:17478-17488.
20. Cruz-Gonzalez I, Corral E, Sanchez-Ledesma M, Sanchez-Rodriguez A, Martin-Luengo C, Gonzalez-Sarmiento R. Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study. BMC Cardiovasc Disord 2009, 9:35. 10.1186/1471-2261-9-35, 2734743, 19650939.
21. Xin Y, Song X, Xue H, Liu Z, Wang X, Wang H, Sun K, Bai Y, Liu J, Hui R. A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension. Clin Sci (Lond) 2009, 117:67-73. 10.1042/CS20080476, 19132956.
22. Yemisci M, Sinici I, Ozkara HA, Hayran M, Ay H, Celtikci B, Onder E, Buyukserbetci G, Kaya EB, Tokgozoglu L, et al. Protective role of 27 bp repeat polymorphism in intron 4 of eNOS gene in lacunar infarction. Free Radic Res 2009, 43:272-279. 10.1080/10715760802691489, 19184759.
23. Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab 2000, 70:241-251. 10.1006/mgme.2000.3033, 10993711.
24. Akcay A, Sezer S, Ozdemir FN, Arat Z, Atac FB, Verdi H, Colak T, Haberal M. Association of the genetic polymorphisms of the renin-angiotensin system and endothelial nitric oxide synthase with chronic renal transplant dysfunction. Transplantation 2004, 78:892-898. 10.1097/01.TP.0000134972.81306.B1, 15385810.
25. Hingorani AD. Polymorphisms in endothelial nitric oxide synthase and atherogenesis: John French Lecture 2000. Atherosclerosis 2001, 154:521-527. 10.1016/S0021-9150(00)00699-7, 11257252.
26. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25:1271-1277. 10.1002/art.1780251101, 7138600.
27. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997, 40:1725. 10.1002/art.1780400928, 9324032.
28. Ferrario F, Rastaldi MP. Histopathological atlas of renal diseases: anti-glomerular basement membrane antibody disease. J Nephrol 2005, 18:351-353.
29. Croker JA, Kimberly RP. Genetics of susceptibility and severity in systemic lupus erythematosus. Curr Opin Rheumatol 2005, 17:529-537. 10.1097/01.bor.0000169360.15701.27, 16093829.
30. Manson JJ, Isenberg DA. The pathogenesis of systemic lupus erythematosus. Neth J Med 2003, 61:343-346.
31. Gaffney PM, Ortmann WA, Selby SA, Shark KB, Ockenden TC, Rohlf KE, Walgrave NL, Boyum WP, Malmgren ML, Miller ME, et al. Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families. Am J Hum Genet 2000, 66:547-556. 10.1086/302767, 1288108, 10677315.
32. Conen D, Glynn RJ, Buring JE, Ridker PM, Zee RY. Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study. J Hypertens 2008, 26:1780-1786. 10.1097/HJH.0b013e3283077eef, 2654571, 18698212.
33. Bernstein KE, Martin BM, Edwards AS, Bernstein EA. Mouse angiotensin-converting enzyme is a protein composed of two homologous domains. J Biol Chem 1989, 264:11945-11951.
34. Campbell R, Sangalli F, Perticucci E, Aros C, Viscarra C, Perna A, Remuzzi A, Bertocchi F, Fagiani L, Remuzzi G, et al. Effects of combined ACE inhibitor and angiotensin II antagonist treatment in human chronic nephropathies. Kidney Int 2003, 63:1094-1103. 10.1046/j.1523-1755.2003.00832.x, 12631093.
35. Bredt DS, Snyder SH. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 1994, 63:175-195. 10.1146/annurev.bi.63.070194.001135, 7526779.
36. Miyahara K, Kawamoto T, Sase K, Yui Y, Toda K, Yang LX, Hattori R, Aoyama T, Yamamoto Y, Doi Y, et al. Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene. Eur JBiochem 1994, 223:719-726.
37. Xu J, Wang Y, Pan F, Stankovich J, Ye D, Lian L, Zhang K, Ding C. Association of ACE gene polymorphism with genetic susceptibility to systemic lupus erythematosus in a Chinese population: a family-based association study. J Rheumatol 2007, 34:2408-2411.
38. Ng DP, Placha G, Choo S, Chia KS, Warram JH, Krolewski AS. A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Diabetes 2006, 55:2660-2663. 10.2337/db06-0496, 16936219.
39. Barbalic M, Skaric-Juric T, Cambien F, Barbaux S, Poirier O, Turek S, Vrhovski-Hebrang D, Cubrilo-Turek M, Rudan I, Rudan P, et al. Gene polymorphisms of the renin-angiotensin system and early development of hypertension. Am JHypertens 2006, 19:837-842.
40. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992, 51:197-205. 1682892, 1319114.
41. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990, 86:1343-1346. 10.1172/JCI114844, 296868, 1976655.
42. Redon J, Chaves FJ, Liao Y, Pascual JM, Rovira E, Armengod ME, Cooper RS. Influence of the I/D polymorphism of the angiotensin-converting enzyme gene on the outcome of microalbuminuria in essential hypertension. Hypertension 2000, 35:490-495.
43. Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, Zwanzger P, Haberger C, Zill P, Ising M, et al. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Mol Psychiatry 2006, 11:1003-1015. 10.1038/sj.mp.4001884, 16924268.
44. Rossi GP, Cesari M, Zanchetta M, Colonna S, Maiolino G, Pedon L, Cavallin M, Maiolino P, Pessina AC. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol 2003, 41:930-937. 10.1016/S0735-1097(02)03012-7, 12651036.
45. Tang W, Yang Y, Wang B, Xiao C. Association between a G894T polymorphism of eNOS gene and essential hypertension in Hani and Yi minority groups of China. Arch Med Res 2008, 39:222-225. 10.1016/j.arcmed.2007.08.002, 18164968.
46. Zhao Q, Su SY, Chen SF, Li B, Gu DF. Association study of the endothelial nitric oxide synthase gene polymorphisms with essential hypertension in northern Han Chinese. Chin Med J (Engl) 2006, 119:1065-1071.