Peptides derived from specific interaction sites of the fibroblast growth factor 2 - FGF receptor complexes induce receptor activation and signaling

Journal of Neurochemistry

Volumn 114, Issue 1, 2010, Pages 74-86

  Manfè, Valentina ^a   Kochoyan, Artur ^a   Bock, Elisabeth ^a   Berezin, Vladimir ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Fibroblast growth factor 2; Mimetic peptide; Neuronal differentiation; Neuronal survival; Partial agonist

Indexed keywords

CANOFIN DERIVATIVE; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; NEUROPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING SITE; COMPLEX FORMATION; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; DENDRIMERS; DRUG PARTIAL AGONISM; FIBROBLAST GROWTH FACTOR 2; LIGANDS; MODELS, MOLECULAR; NEURITES; NEURONS; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SURFACE PLASMON RESONANCE;

EID: 77953299267     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06718.x     Document Type: Article

References (44)

1. Anderson D. J. (1993) Cell fate determination in the peripheral nervous system: the sympathoadrenal progenitor. J. Neurobiol. 24, 185 198.
2. Beenken A. Mohammadi M. (2009) The FGF family: biology, pathophysiology and therapy. Nat. Rev. Drug Discov. 8, 235 253.
3. Bell C. A., Tynan J. A., Hart K. C., Meyer A. N., Robertson S. C. Donoghue D. J. (2000) Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase. Mol. Biol. Cell 11, 3589 3599.
4. Casper D. Blum M. (1995) Epidermal growth factor and basic fibroblast growth factor protect dopaminergic neurons from glutamate toxicity in culture. J. Neurochem. 65, 1016 1026.
5. Cheng Y., Tao Y., Black I. B. DiCicco-Bloom E. (2001) A single peripheral injection of basic fibroblast growth factor (bFGF) stimulates granule cell production and increases cerebellar growth in newborn rats. J. Neurobiol. 46, 220 229.
6. Dono R. (2003) Fibroblast growth factors as regulators of central nervous system development and function. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284, R867 R881.
7. Eckenstein F. P. (1994) Fibroblast growth factors in the nervous system. J. Neurobiol. 25, 1467 1480.
8. Eswarakumar V. P., Lax I. Schlessinger J. (2005) Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 16, 139 149.
9. Furdui C. M., Lew E. D., Schlessinger J. Anderson K. S. (2006) Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction. Mol. Cell 21, 711 717.
10. Gage F. H., Coates P. W., Palmer T. D., Kuhn H. G., Fisher L. J., Suhonen J. O., Peterson D. A., Suhr S. T. Ray J. (1995) Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc. Natl Acad. Sci. USA 92, 11879 11883.
11. Garcia-Maya M., Anderson A. A., Kendal C. E., Kenny A. V., Edwards-Ingram L. C., Holladay A. Saffell J. L. (2006) Ligand concentration is a driver of divergent signaling and pleiotropic cellular responses to FGF. J. Cell. Physiol. 206, 386 393.
12. Goldstrohm A. C., Greenleaf A. L. Garcia-Blanco M. A. (2001) Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing. Gene 277, 31 47.
13. Gritti A., Parati E. A., Cova L. et al. (1996) Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J. Neurosci. 16, 1091 1100.
14. Johnson D. E. Williams L. T. (1993) Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60, 1 41.
15. Kalil K., Szebenyi G. Dent E. W. (2000) Common mechanisms underlying growth cone guidance and axon branching. J. Neurobiol. 44, 145 158.
16. Kiselyov V. V., Kochoyan A., Poulsen F. M., Bock E. Berezin V. (2006) Elucidation of the mechanism of the regulatory function of the Ig1 module of the fibroblast growth factor receptor 1. Protein Sci. 15, 2318 2322.
17. Køhler L. B., Berezin V., Bock E. Penkowa M. (2003) The role of metallothionein II in neuronal differentiation and survival. Brain Res. 992, 128 136.
18. Kokel M., Borland C. Z., DeLong L., Horvitz H. R. Stern M. J. (1998) clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 12, 1425 1437.
19. Kovalenko D., Yang X., Chen P. Y., Nadeau R. J., Zubanova O., Pigeon K. Friesel R. (2006) A role for extracellular and transmembrane domains of Sef in Sef-mediated inhibition of FGF signaling. Cell. Signal. 18, 1958 1966.
20. Li S., Cristensen C., Kiselyov V. V., Køhler L. B., Bock E. Berezin V. (2008) Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor. J. Neurochem. 104, 667 682.
21. Mattson M. P., Murrain M., Guthrie P. B. Kater S. B. (1989) Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture. J. Neurosci. 9, 3728 3740.
22. Mocchetti I. Wrathall J. R. (1995) Neurotrophic factors in central nervous system trauma. J. Neurotrauma 12, 853 870.
23. Mohammadi M., Olsen S. K. Ibrahimi O. A. (2005) Structural basis for fibroblast growth factor receptor activation. Cytokine Growth Factor Rev. 16, 107 137.
24. Neiiendam J. L., Kohler L. B., Christensen C. et al. (2004) An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons. J. Neurochem. 91, 920 935.
25. Okada-Ban M., Thiery J. P. Jouanneau J. (2000) Fibroblast growth factor-2. Int. J. Biochem. Cell Biol. 32, 263 267.
26. Olsen S. K., Ibrahimi O. A., Raucci A. et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc. Natl Acad. Sci. USA 101, 935 940.
27. Ornitz D. M. Itoh N. (2001) Fibroblast growth factors. Genome Biol. 2, 1 12.
28. Otto D. Unsicker K. (1993) FGF-2-mediated protection of cultured mesencephalic dopaminergic neurons against MPTP and MPP+: specificity and impact of culture conditions, non-dopaminergic neurons, and astroglial cells. J. Neurosci. Res. 34, 382 393.
29. Pellegrini L., Burke D. F., von Delft F., Mulloy B. Blundell T. L. (2000) Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature 407, 1029 1034.
30. Plotnikov A. N., Schlessinger J., Hubbard S. R. Mohammadi M. (1999) Structural basis for FGF receptor dimerization and activation. Cell 98, 641 650.
31. Powers C. J., McLeskey S. W. Wellstein A. (2000) Fibroblast growth factors, their receptors and signaling. Endocr. Relat. Cancer 7, 165 197.
32. Reuss B. von Bohlen und Halbach O. (2003) Fibroblast growth factors and their receptors in the central nervous system. Cell Tissue Res. 313, 139 157.
33. Rønn L. C. B., Ralets I., Hartz B. P., Bech M., Berezin A., Berezin V., Møller A. Bock E. (2000) A simple procedure for quantification of neurite outgrowth based on stereological principles. J. Neurosci. Methods 100, 25 32.
34. Saffell J. L., Williams E. J., Mason I. J., Walsh F. S. Doherty P. (1997) Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron 18, 231 242.
35. Schlessinger J., Plotnikov A. N., Ibrahimi O. A., Eliseenkova A. V., Yeh B. K., Yayon A., Linhardt R. J. Mohammadi M. (2000) Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol. Cell 6, 743 750.
36. Schousboe A., Frandsen A. Drejer J. (1989) Evidence for evoked release of adenosine and glutamate from cultured cerebellar granule cells. Neurochem. Res. 14, 871 875.
37. Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J. D. Murison J. G. (2001) Identification of a new fibroblast growth factor receptor, FGFR5. Gene 271, 171 182.
38. Stauber D. J., DiGabriele A. D. Hendrickson W. A. (2000) Structural interactions of fibroblast growth factor receptor with its ligands. Proc. Natl Acad. Sci. USA 97, 49 54.
39. Szebenyi G., Dent E. W., Callaway J. L., Seys C., Lueth H. Kalil K. (2001) Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behavior of the primary growth cone. J. Neurosci. 21, 3932 3941.
40. Tsang M. Dawid I. B. (2004) Promotion and attenuation of FGF signaling through the Ras-MAPK pathway. Sci. STKE 228, pe17.
41. Vescovi A. L., Reynolds B. A., Fraser D. D. Weiss S. (1993) bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells. Neuron 11, 951 966.
42. Wagner J. P., Black I. B. DiCicco-Bloom E. (1999) Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. J. Neurosci. 19, 6006 6016.
43. Wang F., Kan M., Xu J., Yan G. McKeehan W. L. (1995) Ligands-specific structural domains in the fibroblast growth factor receptor. J. Biol. Chem. 270, 10222 10230.
44. Yeh B. K., Igarashi M., Eliseenkova A. V., Plotnikov A. N., Sher I., Ron D., Aaronson S. A. Mohammadi M. (2003) Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. Proc. Natl Acad. Sci. USA 100, 2266 2271.