Acute profound thrombocytopenia following eptifibatide administration

Southern Medical Journal

Volumn 103, Issue 6, 2010, Pages 596-597

  Tahir, Mohammad ^a   Banday, Arshad ^b   Karim, Shahnawaj ^b   Sullivan, Philip R ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIURETIC AGENT; EPTIFIBATIDE; FUROSEMIDE; GLIMEPIRIDE; GLYCERYL TRINITRATE; HEPARIN; IMMUNOGLOBULIN; INSULIN; IRBESARTAN; MESALAZINE; METOPROLOL; SIMVASTATIN; VITAMIN;

AGED; AUTOIMMUNE THROMBOCYTOPENIA; BLOOD CELL COUNT; CASE REPORT; CLINICAL FEATURE; CONGESTIVE HEART FAILURE; DEEP VEIN THROMBOSIS; DRUG WITHDRAWAL; DYSPNEA; ERYTHROCYTE TRANSFUSION; FEMALE; FOOT EDEMA; HUMAN; INTERNATIONAL NORMALIZED RATIO; LETTER; PETECHIA; PNEUMONIA; PROTHROMBIN TIME; THORAX PAIN; THORAX RADIOGRAPHY; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA;

AGED, 80 AND OVER; DIAGNOSIS, DIFFERENTIAL; DRUG THERAPY, COMBINATION; FEMALE; HEART FAILURE; HEPARIN; HUMANS; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PLATELET COUNT; PNEUMONIA; THROMBOCYTOPENIA; VENOUS THROMBOSIS;

EID: 77953293348     PISSN: 00384348     EISSN: None     Source Type: Journal    
DOI: 10.1097/SMJ.0b013e3181de0cca     Document Type: Letter

References (5)

1. Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes. The PURSUIT Trial Investigators. Platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using integrilin therapy. N Engl J Med 1998;339:436-443.
2. Russell KN, Schnabel JG, Rochetto RP, et al. Acute profound thrombocytopenia associated with readministration of eptifibatide: case report and review of the literature. Pharmacotherapy 2009;29:867-874.
3. Hongo RH, Brent BN. Association of eptifibatide and acute profound thrombocytopenia. Am J Cardiol 2001;88:428-431.
4. Bougie DW, Wilker PR, Wuitschick ED, et al. Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/ IIIa. Blood 2002;100:2071-2076.
5. Madan M, Berkowitz SD. Understanding thrombocytopenia and antigenicity with glycoprotein IIb-IIIa inhibitors. Am Heart J 1999; 138:S317-S326.