Neurotensin

Handbook of Biologically Active Peptides

Volumn , Issue , 2006, Pages 737-743

  Dobner, Paul R ^a   Carraway, Robert E ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77953291686     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369442-3/50105-7     Document Type: Chapter

References (73)

1. Alexander MJ, Miller MA, Dorsa DM, Bullock BP, Melloni RH, Dobner PR, Leeman SE Distribution of neurotensin/neuromedin N mRNA in rat forebrain: Unexpected abundance in hippocampus and subiculum. Proc Natl Acad Sci USA 1989, 86:5202-5206.
2. Barbero P, Rovere C, De Bie I, Seidah NG, Beaudet A, Kitabgi P PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfered PC12 cells. J Biol Chem 1998, 273:25339-25346.
3. Bean AJ, Dagerlind A, Hokfelt T, Dobner PR Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. Neurosci 1992, 50:259-268.
4. Beck B, Burlet A, Nicolas J-P, Burlet C Opposite influence of carbohydrate and fat on hypothalamic neurotensin in Long-Evans rats. Life Sci 1996, 59:349-356.
5. Back B, Stricker-Krongrad A, Richy S, Burlet C Evidence that hypothalamic neurotensin signals leptin effects on feeding behavior in normal and fat-preferring rats. Biochem Biophys Res Comm 1998, 252:634-638.
6. Binder E, Kinkead B, Owens MJ, Kilts CD, Nemeroff CB Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating. J Neurosci 2001, 21:601-608.
7. Binder EB, Gross RE, Nemeroff CB, Kilts CD Effects of neurotensin receptor antagonism on latent inhibition in Sprague-Dawley rats. Psychopharmacol 2002, 161:288-295.
8. 10) close to the experimentally derived bioactive conformation of NT(8-13). J Med Chem 2004, 2004:5587-5590.
9. Canonico PL, Spcciale C, Sortino MA, Scapagnini U Involvement of arachidonate metabolism in neurotensin-induced prolactin release in vitro. Am J Physiol 1985, 249:E257-E263.
10. Carraway R, Leeman SE The synthesis of neurotensin. J Biol Chem 1975, 250:1912-1918.
11. Carraway R, Ruane SE, Kim HR Distribution and immunochemical character of neurotensin-like material in representative vertebrates and invertebrates: Apparent conservation of the COOH-terminal region during evolution. Peptides 1982, 3:115-123.
12. Carraway RE, Leeman SE The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem 1973, 248:6854-6861.
13. Carraway RE, Leeman SE The amino acid sequence of a hypothalamic peptide, neurotensin. J Biol Chem 1975, 250:1907-1911.
14. Carraway RE, Ferris CF Isolation, biological and chemical characterization, and synthesis of a neurotensin-related hexapeptide from chicken intestine. J Biol Chem 1983, 258:2475-2479.
15. Carraway RE, Mitra SP Differential processing of neurotensin/neuromedin N precursor(s) in canine brain and intestine. J Biol Chem 1990, 265:8627-8631.
16. Carraway RE, Cochrane DE, Salmonsen R, Muraki K, Boucher W Neurotensin elevates hematocrit and plasma levels of the leukotrienes, LTB4, LTC4, LTD4 and LTE4, in anesthetized rats. Peptides 1991, 12:1105-1111.
17. Carraway RE, Mitra SP Purification of large neuromedin N (NMN) from canine intestine and its identification as NMN-125. Biochem Biophys Res Comm 1991, 179:301-308.
18. Carraway RE, Mitra SP, Spaulding G Posttranslational processing of the neurotensin/neuromedin-N precursor. Ann NY Acad Sci 1992, 668:1-16.
19. Carraway RE, Mitra SP, Joyce TJ Tissue-specific processing of neurotensin/neuromedin-N precursor in cat. Regul Pept 1993, 43:97-106.
20. Carraway RE, Mitra SP Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+dependent adenylly cyclase(s). Mol Cell Endocrinol 1998, 144:47-57.
21. Chartoff EH, Szczypka MS, Palmiter RD, Dorsa DM Endogeneous neurotensin attenuates dopamine-dependent locomotion and stereotypy. Brain Res 2004, 1022:71-80.
22. Ciofi P, Crowley WR, Pillez A, Schmued LL, Tramu G, Mazzuca M Plasticity in expression of immunoreactivity for neuropeptide Y, enkephalins, and neurotens in in the hypothalamic tubero-infundibular, dopaminergic system during lactation in mice. J Neuroendocrinol 1993, 5:599-602.
23. Costa FG, Frussa-Filho R, Felicio LF The neurotensin receptor antagonist, SR48692, attenuates the expression of amphetamine-induced behavioral sensitisation in mice. Eur J Pharmacol 2001, 428:97-103.
24. Dal Farra C, Sarret P, Navarro V, Botto J-M, Mazella J, Vincent J-P Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines. Int J Cancer 2001, 92:503-509.
25. Dobner PR, Barber DL, Villa-Komaroff L, McKiernan C Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor. Proc Natl Acad Sci USA 1987, 84:3516-3520.
26. Dobner PR, Fadel J, Deitemeyer N, Carraway RE, Deutch AY Neurotensin-deficient mice show altered responses to anti-psychotic drugs. Proc Natl Acad Sci USA 2001, 98:8048-8053.
27. Dobner PR, Deutch AY, Fadel J Neurotensin: Dual roles in psychostimulant and antipsychotic drug responses. Life Sci 2003, 73:801-811.
28. Dobner PR Multitasking with neurotensin in the central nervous system. Cell and Mol Life Sci 2005, (in press).
29. Dubuc I, Sarret P, Labbe-Jullie C, Botto JM, Honore E, Bourdel E, Martinez J, Costentin J, Vincent JP, Kitabgi P, Mazella J Identification of the receptor subtype involved in the analgesic effect of neurotensin. J Neurosci 1999, 19:503-510.
30. Fadel, J, Dobner, PR and Deutch, AY. Amphetamine-elicited striatal Fos expression is attenuated in neurotensin-deficient mice. (submitted).
31. Fredrickson P, Boules M, Yerbury S, Richelson E Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization. Brain Res 2003, 979:245-248.
32. Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity. Biochem Biophys Res Comm 2002, 290:1161-1168.
33. Gilbert JA, Richelson E Neurotensin stimulates formation of cyclic GMP in murine neuroblastoma clone N1E-115. Eur J Pharmacol 1984, 99:245-246.
34. Gui X, Carraway RE, Dobner PR Endogenous neurotensin facilitates visceral nociception and is required for stress-induced antinociception in mice and rats. Neurosci 2004, 126:1023-1032.
35. Hassan S, Dobner PR, Carraway R Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of neurotensin on DNA synthesis in PC3 cells. Regul Pept 2004, 120:155-166.
36. Hentschel K, Cheung S, Moore KE, Lookingland KJ Pharmacological evidence that neurotensin mediates prolactin-induced activation of tuberoinfundibular dopamine neurons. Neuroendocrinol 1998, 68:71-76.
37. Kinkead B, Dobner PR, Egnatashvili V, Murrary T, Deitemeyer N, Nemeroff CB Neurotensin-deficient mice have deficits in prepulse inhibition: Restoration by clozapine but not haloperidol, olanzapine or quetiapine. J Pharmacol Exp Ther 2005, (in press).
38. Kislauskis E, Bullock B, McNeil S, Dobner PR The rat gene encoding neurotensin and neuromedin N: Structure, tissue-specific expression, and evolution of exon sequences. J Biol Chem 1988, 263:4963-4968.
39. Kislauskis E, Dobner PR Mutually dependent response elements in the cis-regulatory region of the neurotensin/neuromedin N gene integrate environmental stimuli in PC12 cells. Neuron 1990, 4:783-795.
40. Leonetti M, Brun P, Clerget M, Steinberg R, Soubrie P, Renaud B, Suaud-Chagny M-F Specific involvement of neurotensin type 1 receptor in the neurotensin-mediated in vivo dopamine efflux using knock-out mice. J Neurochem 2004, 89:1-6.
41. Luca S, White JF, Sohal AK, Filippov DV, van Boom JH, Grisshammer R, Baldus M The conformation of neurotensin bound to its G protein-coupled receptor. Proc Natl Acad Sci USA 2003, 100:10706-10711.
42. Luttinger D, King RA, Sheppard D, Strupp J, Nemeroff CB, Prange AJ The effect of neurotensin on food consumption in the rat. Eur J Pharmacol 1982, 81:499-503.
43. Martin S, Vincent J-P, Mazella J Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia. J Neurosci 2003, 23:1198-1205.
44. Mazella J, Poustis C, Labbe C, Checler F, Kitabgi P, Granier C, van Rietschoten J, Vincent J-P Monoiodo-[Trp11]neurotensin, a highly radioactive ligand of neurotensin receptors. Preparation, biological activity and binding properties to rat brain synaptic membranes. J Biol Chem 1983, 258:3476-3481.
45. Mazella J, Zsurger N, Navarro V, Chabry J, Kaghad M, Caput D, Ferrara P, Vita N, Gully D, Maffrand J-P, Vincent J-P The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor. J Biol Chem 1998, 273:26273-26276.
46. Mussdorfer GG, Malendowicz LK, Meneghelli V, Mazzocchi G Neurotensin enhances plasma adrenocorticotropin concentrations by stimulating corticotropin-releasing hormone concentration. Life Sci 1992, 50:639-643.
47. Najimi M, Gailly P, Maloteaux J-M, Hermans E Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins. FEBS Lett 2002, 512:329-333.
48. Nemeroff CB Neurotensin: Perchance an endogenous neuroleptic. Biol Psychiatry 1980, 15:283-302.
49. Nicot A, Bérod A, Gully D, Rowe W, Quirion R, de Kloet ER, Rostène W Blockade of neurotensin binding in the rat hypothalamus and of the central action of neurotensin on the hypothalamic-pituitary-adrenal axis with non-peptide receptor antagonists. Neuroendocrinol 1994, 59:572-578.
50. Oury-Donat F, Thurneyssen O, Gonalons N, Forgez P, Gully D, Le Fur G, Soubrie P Characterization of the effect of SR 48692 on inositol monophosphate, cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells. Br J Pharmacol 1995, 116:1899-1905.
51. Panayi F, Dorso E, Lambas-Senas L, Renaud B, Scarna H, Berod A Chronic blockade of neurotensin receptors strongly reduces sensitized, but not acute, behavioral response to D-amphetamine. Neuropsychopharmacol 2002, 26:64-74.
52. Pettibone DJ, Hess JF, Hey PJ, Jacobson MA, Leviten M, Lis EV, Mallorga PJ, Pascarella DM, Snyder MA, Williams JB, Zeng Z The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. J Pharmacol Exp Ther 2002, 300:305-313.
53. Reinecke M Neurotensin: Immunohistochemical localization in central and peripheral nervous system and in endocrine cells and its functional role as neurotransmitter and endocrine hormone. Progr Histochem Cytochem 1985, 16:1-175.
54. Remaury A, Vita N, Gendreau S, Jung M, Arnone M, Poncelet M, Culouscou JM, Le Fur G, Soubrie P, Caput D, Shire D, Kopf M, Ferrara P Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Brain Res 2002, 953:63-72.
55. Richard F, Barroso S, Martinez J, Labbe-Jullie C, Kitabgi P Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2. Mol Pharmacol 2001, 60:1392-1398.
56. Richy S, Burlet A, Max J-P, Burlet C, Beck B Effect of chronic intraperitoneal injections of leptin on hypothalamic neurotensin content and food intake. Brain Res 2000, 862:276-279.
57. Rompre P-P, Perron S Evidence for a role of endogenous neurotensin in the initiation of amphetamine sensitization. Neuropharmacol 2000, 39:1880-1892.
58. Rostene WH, Alexander MJ Neurotensin and neuroendocrine regulation. Front Neuroendocrinol 1997, 18:115-173.
59. Rovere C, Barbero P, Kitabgi P Evidence that PC2 is the endogenous pro-neurotensin convertase in rMTC 6-23 cells and that PC1- and PC2-transfected PC12 cells differentially process pro-neurotensin. J Biol Chem 1996, 271:11368-11375.
60. Rowe W, Viau V, Meaney MJ, Quirion R Stimulation of CRH-mediated ACTH secretion by central administration of neurotensin: Evidence for the participation of the paraventricular nucleus. J Neuroendocrinol 1995, 7:109-117.
61. Rowe WB, Nicot A, Sharma S, Gully D, Walker C-D, Rostene W, Meaney MJ, Quirion R Central administration of the neurotensin receptor antagonist, SR48692, modulates diurnal and stress-related hypothalamic-pituitary-adrenal activity. Neuroendocrinol 1997, 66:75-85.
62. Sahu A Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinol 1998, 139:795-798.
63. Sahu A, Carraway RE, Wang Y-P Evidence that neurotensin mediates the central effect of leptin on food intake in rat. Brain Res 2001, 888:343-347.
64. Seta KA, Jansen HT, Kreitel KD, Lehman M, Behbehani MM Cold water swim stress increases the expression of neurotensin mRNA in the lateral hypothalamus and medial preoptic regions of the rat brain. Mol Brain Res 2001, 86:145-152.
65. Sharma RP, Janicak PG, Bissette G, Nemeroff CB CSF neurotensin concentrations and antipsychotic treatment in schizophrenia and schizoaffective disorder. Am J Psychiatry 1997, 154:1019-1021.
66. Shi W-X, Bunney BS Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons. J Neuroscience 1992, 12:2433-2438.
67. Smith MJ, Wise PM Neurotensin gene expression increases during proestrus in the rostral medial preoptic nucleus: Potential for direct communication with gonadotropin-releasing hormone neurons. Endocrinology 2001, 142:3006-3013.
68. Villeneuve P, Feliciangeli S, Croissandeau G, Seidah NG, Mbikay M, Kitabgi P, Beaudet A Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: A biochemical and immunohistochemical study. J Neurochem 2002, 82:783-793.
69. Vincent J-P Neurotensin receptors: Binding properties, transduction pathways, and structure. Cell Mol Neurosci 1995, 15:501-512.
70. Williams FG, Beitz AJ Chronic pain increases brainstem proneurotensin/neuromedin-N mRNA expression: A hybridization-histochemical and immunohistochemical study using three different rat models for chronic nociception. Brain Res 1993, 611:87-102.
71. Williamson PT, Bains S, Chung C, Cooke R, Watts A Probing the environment of neurotensin whilst bound to the neurotensin receptor by solid state NMR. FEBS Lett 2002, 518:111-115.
72. Yamada M, Yamada M, Watson MA, Richelson E Deletion mutation in the putative third intracellular loop of the rat neurotensin receptor abolishes polyphosphoinositide hydrolysis but not cyclic AMP formation in CHO-K1 cells. Mol Pharmacol 1994, 46:470-476.
73. Zhang L, Colony PC, Washington JH, Seaton JF, Kauffman GLJ Central neurotensin affects rat gastric integrity, prostaglandin F.2, and blood flow. Am J Physiol 1989, 256:G226-G232.