ACE inhibitor use was associated with lower serum dehydroepiandrosterone concentrations in older men

Clinica Chimica Acta

Volumn 411, Issue 1-16, 2010, Pages 1122-1125

  Kwok, T ^a   Ohlsson, C ^b   Vandenput, L ^b   Tang, N ^a   Zhang, Y F ^a   Tomlinson, B ^a   Leung, P C ^c  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Androgen; Angiotensin converting enzyme; Angiotensin converting enzyme inhibitor; Dehydroepiandrosterone; Gene polymorphism

Indexed keywords

ANDROSTANEDIOL; ANDROSTENEDIONE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ESTRADIOL; ESTRONE; PRASTERONE; PRASTERONE SULFATE; SEX HORMONE; TESTOSTERONE;

AGED; ANDROGEN BLOOD LEVEL; ARTICLE; BODY MASS; CHINESE; COMMUNITY LIVING; CONTROLLED STUDY; DIABETES MELLITUS; DNA POLYMORPHISM; ENZYME ACTIVITY; ESTRADIOL BLOOD LEVEL; GENE FREQUENCY; GENOTYPE; HEART FAILURE; HORMONE DETERMINATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SMOKING; TESTOSTERONE BLOOD LEVEL; WAIST CIRCUMFERENCE;

AGED; ALLELES; ANDROGENS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CHINA; DEHYDROEPIANDROSTERONE; ESTROGENS; GENOTYPE; HUMANS; MALE; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC;

EID: 77953290429     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.04.011     Document Type: Article

References (29)

1. Steele M.K., Gallo R.V., Ganong W.F. A possible role for the brain renin-angiotensin system in the regulation of LH secretion. Am J Physiol 1983, 245:R805-R810.
2. Saavedra J.M., Benicky J., Zhou J. Angiotensin II: multitasking in the brain. J Hypertens Suppl 2006, 24:S131-S137.
3. Dharia S., Parker C.R. Adrenal androgens and aging. Semin Reprod Med 2004, 22:361-368.
4. Yanase T., Maki T., Nawata H., Kato K., Ibayashi H. Effect of angiotensin II on secretion of adrenal androgens. Endocrinol Jpn 1984, 31:741-747.
5. Koshida H., Takeda R., Miyamori Lisinopril decreases plasma free testosterone in male hypertensive patients and increases sex hormone binding globulin in female hypertensive patients. Hypertens Res 1998, 21:279-282.
6. Gronroos P.E., Irjala K.M., Vesalainen R.K., et al. Effects of ramipril on the hormone concentrations in serum of hypertensive patients. Eur J Clin Chem Clin Biochem 1997, 35:411-414.
7. Riggs B.L., Khosla S., Melton L.J. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002, 23:279-302.
8. Labrie F., Belanger A., Cusan L., Gomez J.L., Candas B. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 1997, 82:2396-2402.
9. Nair K.S., Rizza R.A., O'Brien P., et al. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 2006, 355:1647-1659.
10. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990, 86:1343-1346.
11. Danser A.H., Schalekamp M.A., Bax W.A., et al. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation 1995, 92:1387-1388.
12. Costerousse O., Allegrini J., Lopez M., Alhenc-Gelas F. Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem J 1993, 290(Pt 1):33-40.
13. Lynn H., Kwok T., Wong S.Y.S., Woo J., Leung P.C. Angiotensin converting enzyme inhibitor use is associated with higher bone mineral density in elderly Chinese. Bone 2006, 38:584-588.
14. Washburn R.A. The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol 1993, 46:153-162.
15. Labrie F., Belanger A., Belanger P., et al. Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women. J Steroid Biochem Mol Biol 2006, 99(4-5):182-188.
16. Labrie F., Cusan L., Gomez J.L., et al. Comparable amounts of sex steroids are made outside the gonads in men and women: Strong lesson for hormone therapy of prostate and breast cancer. J Steroid Biochem Mol Biol 2009, 11(1-2):52-56.
17. Sodergard R., Backstrom T., Shanbhag V., Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982, 6(6):801-810.
18. Tsai E.C., Matsumoto A.M., Fujimoto W.Y., Boyko E.J. Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care 2004, 27:861-868.
19. Moriyama Y., Yasue H., Yoshimura M., et al. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrinol Metab 2000, 85(5):1834-1840.
20. Kwok T., Woo J., Lau E. Prediction of body fat by anthropometry in older Chinese people. Obes Res 2001, 9:97-101.
21. Thomas G.N., Lao X.Q., Jiang C.Q., et al. Implications of increased weight and waist circumference on vascular risk in an older Chinese population: the Guangzhou Biobank Cohort Study. Atheroscl 2008, 196(2):682-688.
22. Sulcova J., Stulc T., Hill M., et al. Decrease in serum dehydroepiandrosterone level after fenofibrate treatment in males with hyperlipidemia. Physiol Res 2005, 54(2):151-157.
23. Masunari N., Fujiwara S., Nakata Y., Furukawa K., Kasagi F. Effect of angiotensin converting enzyme inhibitor and benzodiazepine intake on bone loss in older Japanese. Hiroshima J Med Sci 2008, 57(1):17-25.
24. Izu Y., Mizoguchi F., Kawamata A., et al. Angiotensin II type 2 receptor blockade increases bone mass. J Biol Chem 2009, 284(8):4857-4864.
25. Khanum A., Dufau M.L. Angiotensin II receptors and inhibitory actions in Leydig Cells. J Biol Chem 1988, 263:5070-5074.
26. Douglas G.C., O'Bryan M.K., Hedger M.P., et al. The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology 2004, 145(10):4703-4711.
27. Santner S.J., Albertson B., Zhang G.Y., et al. Comparative rates of androgen production and metabolism in Caucasian and Chinese subjects. J Clin Endocrinol Metab 1998, 83:2104-2109.
28. Wang J.G., Liu L., Zagato L., et al. Blood pressure in relation to three candidate genes in a Chinese population. J Hypert 2004, 22(5):937-944.
29. Chang Y.C., Wu W.M., Chen C.H., Lee S.H., Hong H.S., Hsu L.A. Association between the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and risk for psoriasis in a Chinese population in Taiwan. Brit J Dermatol 2007, 156(4):642-645.