Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 11, 2010, Pages 3405-3408

  Peters, Jens Uwe ^a   Hoffmann, Torsten ^a   Schnider, Patrick ^a   Stadler, Heinz ^a   Koblet, Andreas ^a   Alker, André ^a   Poli, Sonia Maria ^a   Ballard, Theresa M ^a   Spooren, Will ^a   Steward, Lucinda ^a   Sleight, Andrew J ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antipsychotic; Dual ligand; Neurokinin receptor; Schizophrenia

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; APREPITANT; L 759274; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR ANTAGONIST; NEUROLEPTIC AGENT; OSANETANT; TALNETANT;

ARTICLE; CRYSTAL STRUCTURE; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; SINGLE DRUG DOSE; SUZUKI REACTION;

ADMINISTRATION, ORAL; ANIMALS; DRUG DISCOVERY; LIGANDS; MODELS, MOLECULAR; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-3;

GERBILLINAE;

EID: 77953287702     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.008     Document Type: Article

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