Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1362-1365

  Hoffmann, Torsten ^a   Bös, Michael ^a   Stadler, Heinz ^a   Schnider, Patrick ^a   Hunkeler, Walter ^a   Godel, Thierry ^a   Galley, Guido ^a   Ballard, Theresa M ^a   Higgins, Guy A ^a   Poli, Sonia M ^a   Sleight, Andrew J ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Drug design and synthesis; G protein coupled receptor; NK1 receptor antagonist

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; APREPITANT; BEFETIPITANT; BIPHENYL DERIVATIVE; ISOCYCLIC BIPHENYL DERIVATIVE; NETUPITANT; NEUROKININ 1 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

ADMINISTRATION, ORAL; AMINES; ANIMALS; CHO CELLS; CRICETINAE; CROSS-LINKING REAGENTS; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; PYRIDINES; PYRIMIDINES; RECEPTORS, NEUROKININ-1; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 31344467090     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.047     Document Type: Article

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