Cumulative lead exposure and prospective change in cognition among elderly men: The VA normative aging study

American Journal of Epidemiology

Volumn 160, Issue 12, 2004, Pages 1184-1193

  Weisskopf, Marc G ^a   Wright, Robert O ^a,b,c   Schwartz, Joel ^a   Spiro III, Avion ^d,e   Sparrow, David ^d,e,f   Aro, Antonio ^a,c   Hu, Howard ^a,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone and bones; Lead; Neuropsychological tests; Prospective studies

Indexed keywords

BIOCHEMICAL MARKER; LEAD;

COGNITION; ELDERLY POPULATION; LEAD; MEDICAL GEOGRAPHY; POLLUTION EXPOSURE;

ADULT; AGED; AGING; ALCOHOL CONSUMPTION; ARTICLE; CIGARETTE SMOKING; COGNITION; DATA ANALYSIS; ENVIRONMENTAL EXPOSURE; HUMAN; LEAD BLOOD LEVEL; LEAD POISONING; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; OCCUPATIONAL EXPOSURE; PATELLA; PROSPECTIVE STUDY; SCORING SYSTEM; SEX DIFFERENCE; X RAY FLUORESCENCE;

ADULT; AGED; AGED, 80 AND OVER; AGING; COGNITION; COHORT STUDIES; ENVIRONMENTAL EXPOSURE; HUMANS; LEAD; MALE; MIDDLE AGED; PATELLA; PSYCHOLOGICAL TESTS; TIBIA;

NORTH AMERICA; UNITED STATES; VIRGINIA; WESTERN HEMISPHERE; WORLD;

EID: 10344245544     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/aje/kwh333     Document Type: Article

References (67)

1. Day JC, ed. Population projections of the United States by age, sex, race, and Hispanic origin: 1995 to 2050. Washington, DC: US Government Printing Office, 1996. (US Bureau of the Census current population reports, publication no. P25-1130).
2. Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Public Health 1998;88:1337-42.
3. Bedard M, Pedlar D, Martin NJ, et al. Burden in caregivers of cognitively impaired older adults living in the community: methodological issues and determinants. Int Psychogeriatr 2000;12:307-32.
4. Bassuk SS, Wypij D, Berkman LF. Cognitive impairment and mortality in the community-dwelling elderly. Am J Epidemiol 2000;151:676-88.
5. Hebert R, Brayne C, Spiegelhalter D. Factors associated with functional decline and improvement in a very elderly community-dwelling population. Am J Epidemiol 1999;150:501-10.
6. Park DC, Nisbett R, Hedden T. Aging, culture, and cognition. J Gerontol B Psychol Sci Soc Sci 1999;54:75-84.
7. Rowe JW, Kahn RL. Successful aging. Gerontologist 1997;37: 433-40.
8. Tabert MH, Albert SM, Borukhova-Milov L, et al. Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurology 2002;58:758-64.
9. Tuokko HA, Frerichs RJ, Kristjansson B. Cognitive impairment, no dementia: concepts and issues. Int Psychogeriatr 2001;13:183-202.
10. Banks EC, Ferretti LE, Shucard DW. Effects of low level lead exposure on cognitive function in children: a review of behavioral, neuropsychological and biological evidence. Neurotoxicology 1997;18:237-81.
11. Canfield RL, Henderson CR Jr, Cory-Slechta DA, et al. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med 2003;348:1517-26. 2
12. Needleman HL, Gatsonis CA. Low-level lead exposure and the IQ of children. A meta-analysis of modern studies. JAMA 1990;263:673-8.
13. Schwartz J. Low-level lead exposure and children's IQ: a meta-analysis and search for a threshold. Environ Res 1994;65:42-55. .
14. Balbus-Kornfeld JM, Stewart W, Bolla KI, et al. Cumulative exposure to inorganic lead and neurobehavioural test performance in adults: an epidemiological review. Occup Environ Med 1995;52:2-12.
15. Bleecker ML, Lindgren KN, Ford DP. Differential contribution of current and cumulative indices of lead dose to neuropsychological performance by age. Neurology 1997;48:639-45.
16. Fiedler N, Weisel C, Lynch R, et al. Cognitive effects of chronic exposure to lead and solvents. Am J Ind Med 2003;44: 413-23.
17. Schwartz BS, Stewart WF. Different associations of blood lead, meso 2,3-dimercaptosuccinic acid (DMSA)-chelatable lead, and tibial lead levels with blood pressure in 543 former organolead manufacturing workers. Arch Environ Health 2000;55: 85-92.
18. Stewart WF, Schwartz BS, Simon D, et al. Neurobehavioral function and tibial and chelatable lead levels in 543 former organolead workers. Neurology 1999;52:1610-17.
19. Muldoon SB, Cauley JA, Kuller LH, et al. Effects of blood lead levels on cognitive function of older women. Neuroepidemiology 1996;15:62-72.
20. Payton M, Riggs KM, Spiro A 3rd, et al. Relations of bone and blood lead to cognitive function: the VA Normative Aging Study. Neurotoxicol Teratol 1998;20:19-27.
21. Wright RO, Tsaih SW, Schwartz J, et al. Lead exposure biomarkers and mini-mental status exam scores in older men. Epidemiology 2003;14:713-18.
22. Nordberg M, Winblad B, Fratiglioni L, et al. Lead concentrations in elderly urban people related to blood pressure and mental performance: results from a population-based study. Am J Ind Med 2000;38:290-4.
23. Schwartz BS, Stewart WF, Bolla KI, et al. Past adult lead exposure is associated with longitudinal decline in cognitive function. Neurology 2000;55:1144-50.
24. Bell B, Rose CL, Damon A. The Veterans Administration longitudinal study of healthy aging. Gerontologist 1966;6:179-84.
25. Hu H, Payton M, Korrick S, et al. Determinants of bone and blood lead levels among community-exposed middle-aged to elderly men. The Normative Aging Study. Am J Epidemiol 1996;144:749-59.
26. Cheng Y, Willett WC, Schwartz J, et al. Relation of nutrition to bone lead and blood lead levels in middle-aged to elderly men. The Normative Aging Study. Am J Epidemiol 1998;147:1162-74.
27. Kim, R, Landrigan C, Mossmann P, et al. Age and secular trends in bone lead levels in middle-aged and elderly men: three-year longitudinal follow-up in the Normative Aging Study. Am J Epidemiol 1997;146:586-91.
28. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
29. Dufouil C, Clayton D, Brayne C, et al. Population norms for the MMSE in the very old: estimates based on longitudinal data. Mini-Mental State Examination. Neurology 2000;55:1609-13.
30. Tombaugh TN, McIntyre NJ. The Mini-Mental State Examination: a comprehensive review. J Am Geriatr Soc 1992;40:922-35.
31. Hu H, Rabinowitz M, Smith D. Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect 1998;106:1-8.
32. Hu H, Milder FL, Burger DE. X-ray fluorescence measurements of lead burden in subjects with low-level community lead exposure. Arch Environ Health 1990;45:335-41.
33. 109Cd K x-ray fluorescence systems for measuring bone lead in vivo. Phys Med Biol 1994;39:2263-71.
34. Rosner B. Percentage points for a generalized ESD many-outlier procedure. Technometrics 1983;25:165-72.
35. Rexrode KM, Carey VJ, Hennekens CH, et al. Abdominal adiposity and coronary heart disease in women. JAMA 1998;280: 1843-8.
36. Whitsel EA, Boyko EJ, Matsumoto AM, et al. Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis. Am J Med 2001;111:261-9.
37. Carey VJ, Walters EE, Colditz GA, et al. Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses' Health Study. Am J Epidemiol 1997;145:614-19.
38. Hu H, Aro A, Payton M, et al. The relationship of bone and blood lead to hypertension. The Normative Aging Study. JAMA 1996;275:1171-6.
39. Akaike H. A new look at the statistical model identification. IEEE Trans Automatic Control 1974;19:716-23.
40. SAS Institute, Inc. SAS/STAT user's guide, version 8. Cary, NC: SAS Institute, Inc, 1999.
41. Chia SE, Chia HP, Ong CN, et al. Cumulative blood lead levels and neurobehavioral test performance. Neurotoxicology 1997; 18:793-803.
42. Hanninen H, Aitio A, Kovala T, et al. Occupational exposure to lead and neuropsychological dysfunction. Occup Environ Med 1998;55:202-9.
43. Lindgren KN, Masten VL, Ford DP, et al. Relation of cumulative exposure to inorganic lead and neuropsychological test performance. Occup Environ Med 1996;53:472-7.
44. Lucchini R, Albini E, Cortesi I, et al. Assessment of neurobehavioral performance as a function of current and cumulative occupational lead exposure. Neurotoxicology 2000;21:805-11.
45. Schwartz BS, Lee BK, Lee GS, et al. Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers. Am J Epidemiol 2001;153:453-64.
46. Baker EL, White RF, Pothier LJ, et al. Occupational lead neurotoxicity: improvement in behavioural effects after reduction of exposure. Br J Ind Med 1985;42:507-16.
47. Yokoyama K, Araki S, Aono H. Reversibility of psychological performance in subclinical lead absorption. Neurotoxicology 1988;9:405-10.
48. Mantere P, Hanninen H, Hernberg S, et al. A prospective follow-up study on psychological effects in workers exposed to low levels of lead. Scand J Work Environ Health 1984;10:43-50.
49. Stollery BT, Broadbent DE, Banks HA, et al. Short term prospective study of cognitive functioning in lead workers. Br J Ind Med 1991;48:739-49.
50. Braga MF, Pereira EF, Albuquerque EX. Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. Brain Res 1999;826:22-34.
51. Kober TE, Cooper GP. Lead competitively inhibits calcium-dependent synaptic transmission in the bullfrog sympathetic ganglion. Nature 1976;262:704-5.
52. Lasley SM, Gilbert ME. Glutamatergic components underlying lead-induced impairments in hippocampal synaptic plasticity. Neurotoxicology 2000;21:1057-68.
53. Minnema DJ, Greenland RD, Michaelson IA. Effect of in vitro inorganic lead on dopamine release from superfused rat striatal synaptosomes. Toxicol Appl Pharmacol 1986;84:400-11.
54. Silbergeld EK, Fales JT, Goldberg AM. Evidence for a junctional effect of lead on neuromuscular function. Nature 1974; 247:49-50.
55. Goldstein GW, Ar D. Lead activates calmodulin sensitive processes. Life Sci 1983;33:1001-6.
56. Goldstein GW. Evidence that lead acts as a calcium substitute in second messenger metabolism. Neurotoxicology 1993;14: 97-101.
57. Salthouse TA. The processing-speed theory of adult age differences in cognition. Psychol Rev 1996;103:403-28.
58. 2+ promotes lipid oxidation and alterations in membrane physical properties. Toxicology 1999; 132:19-32.
59. Acharya S, Acharya UR. In vivo lipid peroxidation responses of tissues in lead-treated Swiss mice. Ind Health 1997;35: 542-4.
60. Ercal N, Treeratphan P, Hammond TC, et al. In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine. Free Radic Biol Med 1996;21:157-61.
61. Petersen RC, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985-92.
62. McCarten JR, Rottunda SJ, Kuskowski MA. Change in the mini-mental state exam in Alzheimer's disease over 2 years: the experience of a dementia clinic. J Alzheimers Dis 2004;6:11-15.
63. Raji MA, Al Snih S, Ray LA, et al. Cognitive status and incident disability in older Mexican Americans: findings from the Hispanic established population for the epidemiological study of the elderly. Ethn Dis 2004;14:26-31.
64. Wlodarczyk JH, Brodaty H, Hawthorne G. The relationship between quality of life, Mini-Mental State Examination, and the instrumental activities of daily living in patients with Alzheimer's disease. Arch Gerontol Geriatr 2004;39:25-33.
65. Fitzmaurice G. Regression to the mean. Nutrition 2000;16: 80-1.
66. Fitzmaurice G. A conundrum in the analysis of change. Nutrition 2001;17:360-1.
67. Yanez ND 3rd, Kronmal RA, Shemanski LR. The effects of measurement error in response variables and tests of association of explanatory variables in change models. Stat Med 1998; 17:2597-606.