N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc

Tetrahedron Letters

Volumn 51, Issue 24, 2010, Pages 3216-3217

  Mullen, Philip ^a,b   Miel, Hugues ^a   Anthony McKervey, M ^a  

^a Almac Sciences   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MARAVIROC; N BUTOXYCARBONYL 4 NITROPIPERIDINE; N BUTOXYCARBONYLPIPERIDONE; PIPERIDINE DERIVATIVE; PIPERIDONE DERIVATIVE; SPIRO COMPOUND; SPIROPIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; REACTION ANALYSIS; SYNTHESIS;

EID: 77953233267     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.04.046     Document Type: Article

References (16)

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14. 3) δ 27.9, 29.5, 43.0, 79.6, 80.5, 154.0.
15. We initially tried to prepare compound 1 by dimethyldioxirane oxidation of 4-amino 1-Boc-piperidine. Whilst this method allowed us to prepare the first analytical sample of compound 1, the yield was low and a large excess of dimethyldioxirane was required. {A figure is presented}
16. The microwave-assisted reactions were run in a Biotage Initiator™ microwave oven.