Grueneberg ganglion neurons are finely tuned cold sensors

Journal of Neuroscience

Volumn 30, Issue 22, 2010, Pages 7563-7568

  Schmid, Andreas ^a   Pyrski, Martina ^a   Biel, Martin ^b   Leinders Zufall, Trese ^a   Zufall, Frank ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CNGA3 CHANNEL; CYCLIC GMP; GUANYLATE CYCLASE; LIGAND; PHOSPHODIESTERASE; PHOSPHODIESTERASE 2; TETRODOTOXIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN NERVE CELL; CALCIUM SIGNALING; CELL POPULATION; COLD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COOLING; FEAR; FEMALE; GANGLION; GENDER; MALE; MOUSE; NERVE POTENTIAL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSE ORGAN; SENSOR; STRESS; TEMPERATURE; TEMPERATURE SENSITIVITY;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CALCIUM SIGNALING; COLD TEMPERATURE; CYCLIC GMP; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; FORSKOLIN; GANGLIA, SENSORY; GREEN FLUORESCENT PROTEINS; ISOTHIOCYANATES; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; NASAL CAVITY; OLFACTORY BULB; OLFACTORY MARKER PROTEIN; OLFACTORY PATHWAYS; PHOSPHODIESTERASE INHIBITORS; PYRIMIDINONES; SENSORY RECEPTOR CELLS; SODIUM CHANNEL BLOCKERS; TEMPERATURE SENSE; TETRODOTOXIN; TIME FACTORS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 77953225061     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0608-10.2010     Document Type: Article

References (33)

1. Biel M, Seeliger M, Pfeifer A, Kohler K, Gerstner A, Ludwig A, Jaissle G, Fauser S, Zrenner E, Hofmann F (1999) Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A 96:7553-7557. (Pubitemid 29299700)
2. Blumberg MS, Efimova IV, Alberts JR (1992) Ultrasonic vocalizations by rat pups: the primary importance of ambient temperature and the thermal significance of contact comfort. Dev Psychobiol 25:229-250.
3. Brechbühl J, Klaey M, Broillet MC (2008) Grueneberg ganglion cells mediate alarm pheromone detection in mice. Science 321:1092-1095.
4. Crawley JN (2000) What's wrong with my mouse? Behavioral phenotyping of transgenic and knockout mice. New York: Wiley.
5. Fleischer J, Hass N, Schwarzenbacher K, Besser S, Breer H (2006) A novel population of neuronal cells expressing the olfactory marker protein (OMP) in the anterior/dorsal region of the nasal cavity. Histochem Cell Biol 125:337-349. (Pubitemid 43376199)
6. Fleischer J, Mamasuew K, Breer H (2009) Expression of cGMP signaling elements in the Grueneberg ganglion. Histochem Cell Biol 131:75-88.
7. Fülle HJ, Vassar R, Foster DC, Yang RB, Axel R, Garbers DL (1995) A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proc Natl Acad Sci U S A 92:3571-3575.
8. Fuss SH, Omura M, Mombaerts P (2005) The Grueneberg ganglion of the mouse projects axons to glomeruli in the olfactory bulb. Eur J Neurosci 22:2649-2654. (Pubitemid 41759007)
9. Grosmaitre X, Santarelli LC, Tan J, Luo M, MaM (2007) Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors. Nat Neurosci 10:348-354. (Pubitemid 46310475)
10. Grüneberg H (1973) A ganglion probably belonging to the N. terminalis system in the nasal mucosa of the mouse. Z Anat Entwicklungsgesch 140:39-52.
11. Hashimoto H, Moritani N, Aoki-Komori S, Tanaka M, Saito TR (2004) Comparison of ultrasonic vocalizations emitted by rodent pups. Exp Anim 53:409-416. (Pubitemid 41349883)
12. Jordt SE, McKemy DD, Julius D (2003) Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol 13:487-492.
13. Juilfs DM, Fülle HJ, Zhao AZ, Houslay MD, Garbers DL, Beavo JA (1997) A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proc Natl Acad Sci U S A 94:3388-3395.
14. Koos DS, Fraser SE (2005) The Grueneberg ganglion projects to the olfactory bulb. Neuroreport 16:1929-1932.
15. Kuhara A, Okumura M, Kimata T, Tanizawa Y, Takano R, Kimura KD, Inada H, Matsumoto K, Mori I (2008) Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans. Science 320:803-807. (Pubitemid 351929631)
16. Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP (2006) TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50:277-289.
17. Leinders-Zufall T, Lane AP, Puche AC, Ma W, Novotny MV, Shipley MT, Zufall F (2000) Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature 405:792-796. (Pubitemid 30407851)
18. Leinders-Zufall T, Cockerham RE, Michalakis S, Biel M, Garbers DL, Reed RR, Zufall F, Munger SD (2007) Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci U S A 104:14507-14512. (Pubitemid 350003291)
19. Liu CY, Fraser SE, Koos DS (2009) Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway. J Comp Neurol 516:36-48.
20. Mamasuew K, Breer H, Fleischer J (2008) Grueneberg ganglion neurons respond to cool ambient temperatures. Eur J Neurosci 28:1775-1785.
21. Meyer MR, Angele A, Kremmer E, Kaupp UB, Muller F (2000) A cGMP-signaling pathway in a subset of olfactory sensory neurons. Proc Natl Acad Sci U S A 97:10595-10600.
22. Michalakis S, Reisert J, Geiger H, Wetzel C, Zong X, Bradley J, Spehr M, Hüttl S, Gerstner A, Pfeifer A, Hatt H, Yau KW, Biel M (2006) Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. J Biol Chem 281:35156-35166.
23. Munger SD, Leinders-Zufall T, Zufall F (2009) Subsystem organization of the mammalian sense of smell. Annu Rev Physiol 71:115-140.
24. Nilius B, Voets T (2007) Neurophysiology: channelling cold reception. Nature 448:147-148.
25. Potter SM, Zheng C, Koos DS, Feinstein P, Fraser SE, Mombaerts P (2001) Structure and emergence of specific olfactory glomeruli in the mouse. J Neurosci 21:9713-9723. (Pubitemid 34184057)
26. Ramot D, MacInnis BL, Goodman MB (2008) Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans. Nat Neurosci 11:908-915.
27. Roppolo D, Ribaud V, Jungo VP, Lüscher C, Rodriguez I (2006) Projection of the Grüneberg ganglion to the mouse olfactory bulb. Eur J Neurosci 23:2887-2894. (Pubitemid 43882867)
28. Storan MJ, Key B (2006) Septal organ of Grüneberg is part of the olfactory system. J Comp Neurol 494:834-844.
29. Szentgyörgyi H, Kapusta J, Marchlewska-Koj A (2008) Ultrasonic calls of bank vole pups isolated and exposed to cold or to nest odor. Physiol Behav 93:296-303.
30. Venkatachalam K, Montell C (2007) TRP channels. Annu Rev Biochem 76:387-417.
31. Walz A, Feinstein P, Khan M, Mombaerts P (2007) Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F. Development 134:4063-4072. (Pubitemid 350269423)
32. Zimmermann K, Leffler A, Babes A, Cendan CM, Carr RW, Kobayashi J, Nau C, Wood JN, Reeh PW (2007) Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature 447:855-858. (Pubitemid 46920141)
33. Zufall F, Munger SD (2010) Receptor guanylyl cyclases in mammalian olfactory function. Mol Cell Biochem 334:191-197.