Review: Treatment of Gastroesophageal Reflux Disease in the Elderly

American Journal of Medicine

Volumn 123, Issue 6, 2010, Pages 496-501

  Poh, Choo Hean ^a   Navarro Rodriguez, Tomás ^a   Fass, Ronnie ^a  

^a SOUTHERN ARIZONA VA HEALTH CARE SYSTEM   (United States)

Author keywords

Aging; Gastroesophageal disease; Proton pump inhibitors

Indexed keywords

ALUMINUM HYDROXIDE; ANTACID AGENT; BACLOFEN; CALCIUM CARBONATE; CIMETIDINE; DOMPERIDONE; HISTAMINE H2 RECEPTOR ANTAGONIST; MAGNESIUM HYDROXIDE; METOCLOPRAMIDE; OMEPRAZOLE; PANTOPRAZOLE; PHENYTOIN; PROKINETIC AGENT; PROTON PUMP INHIBITOR; SUCRALFATE; THEOPHYLLINE; WARFARIN;

AGED; ANTIREFLUX OPERATION; COMORBIDITY; CONFUSION; CONSTIPATION; DIARRHEA; DISEASE SEVERITY; DROWSINESS; DRUG ERUPTION; DRUG MECHANISM; DRUG METABOLISM; DRUG SAFETY; DYSPHAGIA; DYSPLASIA; ESOPHAGITIS; GALACTORRHEA; GASTRIN BLOOD LEVEL; GASTROESOPHAGEAL REFLUX; GYNECOMASTIA; HEADACHE; HEART ARRHYTHMIA; HEPATITIS; HUMAN; INSOMNIA; INTERSTITIAL NEPHRITIS; INTESTINE METAPLASIA; LONG TERM CARE; NAUSEA; NEOPLASM; POLYPHARMACY; PREVALENCE; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; REVIEW; SHORT COURSE THERAPY; SIDE EFFECT; STOMACH DISEASE; TARDIVE DYSKINESIA; VOMITING;

AGE FACTORS; AGED; AGING; ANTACIDS; DOPAMINE ANTAGONISTS; ENDOSCOPY, GASTROINTESTINAL; GASTROESOPHAGEAL REFLUX; HISTAMINE H2 ANTAGONISTS; HUMANS; LIFE STYLE; PREVALENCE; PROTON PUMP INHIBITORS; REMISSION INDUCTION; TREATMENT OUTCOME; UNITED STATES;

EID: 77953216556     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2009.07.036     Document Type: Review

References (48)

1. Greenwald D.A. Aging, the gastrointestinal tract, and risk of acid-related disease. Am J Med 117 (2004) 8S-13S
2. Locke III G.R., Talley N.J., Fett S.L., et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmstead County, Minnesota. Gastroenterology 112 (1997) 1448-1456
3. Räihä I.J., Impivaara O., Seppälä M., and Sourander L.B. Prevalence and characteristics of symptomatic gastroesophageal reflux disease in the elderly. J Am Geriatr Soc 40 (1992) 1209-1211
4. Zhu H., Pace F., Sangaletti O., et al. Features of symptomatic gastroesophageal reflux in elderly patients. Scand J Gastroenterol 28 (1993) 235-238
5. Shaker R., Ren J., Zamir Z., et al. Effect of aging, position, and temperature on the threshold volume triggering pharyngeal swallows. Gastroenterology 107 (1994) 396-402
6. Plant R.L. Anatomy and physiology of swallowing in adults and geriatrics. Otolaryngol Clin North Am 31 (1998) 447-488
7. Collen M.J., Abdulian J.D., and Chen Y.K. Age does not affect basal gastric acid secretion in normal subjects or in patients with acid-peptic disease. Am J Gastroenterol 89 (1994) 712-716
8. Hurwitz A., Brady D.A., Schaal S.E., et al. Gastric acidity in older adults. JAMA 278 (1997) 659-662
9. Mold J.W., Reed L.E., Davis A.B., et al. Prevalence for gastroesophageal reflux in elderly patients in a primary care setting. Am J Gastroenterol 86 (1991) 965-970
10. Tack J., and Vantrappen G. The aging oesophagus. Gut 41 (1997) 422-424
11. Khajanchee Y.S., Urbach D.R., Butler N., et al. Laparoscopic antireflux surgery in the elderly. Surg Endosc 16 (2002) 25-30
12. Patti M.G., Goldberg H.I., Arcerito M., et al. Hiatal hernia size affects lower esophageal sphincter function, esophageal acid exposure, and the degree of mucosal injury. Am J Surg 171 (1996) 182-186
13. Pilotto A., Franceschi M., Leandro G., et al. Clinical features of reflux esophagitis in older people: a study of 840 consecutive patients. J Am Geriatr Soc 54 (2006) 1537-1542
14. Räihä I., Hietanen E., and Sourander L. Symptoms of gastro-oesophageal reflux disease in elderly people. Age Ageing 20 (1991) 365-370
15. Collen M.J., Abdulian J.D., and Chen Y.K. Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol 90 (1995) 1053-1057
16. Johnson D.A., and Fennerty M.B. Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease. Gastroenterology 126 (2004) 660-664
17. Fass R., Pulliam G., Johnson C., et al. Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastro-oesophageal reflux. Age Ageing 29 (2000) 125-130
18. Kaltenbach T., Crockett S., and Gerson L.B. Are lifestyle measures effective in patients with gastroesophageal reflux disease?. An evidence-based approach. Arch Intern Med 166 (2006) 965-971
19. Weberg R., and Berstad A. Symptomatic effect of a low-dose antacid regimen in reflux oesophagitis. Scand J Gastroenterol 24 (1989) 401-406
20. Carling L., Cronstedt J., Engqvist A., et al. Sucralfate versus placebo in reflux esophagitis. A double-blind multicenter study. Scand J Gastroenterol 23 (1988) 1117-1124
21. Richter J.E. Novel medical therapies for gastroesophageal reflux disease beyond proton-pump inhibitors. Gastroenterol Clin North Am 31 (2002) S111-S116
22. Richter J.E. Gastroesophageal reflux disease in the older patient: presentation, treatment, and complications. Am J Gastroenterol 95 (2000) 368-373
23. Lipsy F.J., Fennerty B., and Fagan T.C. Clinical review of histamine2 receptor antagonists. Arch Intern Med 150 (1990) 745-755
24. Boustani M., Hall K.S., Lane K.A., et al. The association between cognition and histamine-2 receptor antagonists in African Americans. J Am Geriatr Soc 55 (2007) 1248-1253
25. James O.F., and Parry-Billings K.S. Comparison of omeprazole and histamine H2-receptor antagonists in the treatment of elderly and young patients with reflux oesophagitis. Age Ageing 23 (1994) 121-126
26. Pilotto A., Leandro G., Franceschi M., and Ageing and Acid-Related Disease Study Group. Short- and long-term therapy for reflux oesophagitis in the elderly: a multi-centre, placebo-controlled study with pantoprazole. Aliment Pharmacol Ther 17 (2003) 1399-1406
27. Cheer S.M., Prakash A., Faulds D., and Lamb H.M. Pantoprazole: an update of its pharmacological properties and therapeutic use in the management of acid-related disorders. Drugs 63 (2003) 101-133
28. McColl K.E.L. Effect of proton pump inhibitors on vitamins and iron. Am J Gastroenterol 104 (2009) S5-S9
29. Juurlink D.N., Gomes T., Ko D.T., et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ 180 (2009) 713-718
30. Wilde M.I., and McTavish D. Omeprazole. An update of its pharmacology and therapeutic use in acid-related disorders. Drugs 48 (1994) 91-132
31. Koury S.I., Stone C.K., and La Charité D.D. Omeprazole and the development of acute hepatitis. Eur J Emerg Med 5 (1998) 467-469
32. Yip D., Kovac S., Jardine M., et al. Omeprazole-induced interstitial nephritis. J Clin Gastroenterol 25 (1997) 450-452
33. Jose J., Saravu K., Khera K., et al. Acute interstitial nephritis related to lansoprazole administration. J Pak Med Assoc 58 (2008) 206-207
34. Geevasinga N., Coleman P.L., and Roger S.D. Rabeprazole-induced acute interstitial nephritis. Nephrology (Carlton) 10 (2005) 7-9
35. Singh P., Indaram A., Greenberg R., et al. Long term omeprazole therapy for reflux esophagitis: follow-up in serum gastrin levels, EC cell hyperplasia and neoplasia. World J Gastroenterol 6 (2000) 789-792
36. Hage E., Hendel L., Gustafsen J., and Hendel J. Histopathology of the gastric oxyntic mucosa in two different patient groups during long-term treatment with omeprazole. Eur J Gastroenterol Hepatol 15 (2003) 781-789
37. O'Connell M.B., Madden D.M., Murray A.M., et al. Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med 118 (2005) 778-781
38. Yang Y.X., Lewis J.D., Epstein S., and Metz D.C. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA 296 (2006) 2947-2953
39. Laheij R.J.F., Sturkenboom M.C.J.M., Hassing R.-J., et al. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA 292 (2004) 1955-1960
40. Dial S., Alrasadi K., Manoukian C., et al. Risk of Clostridium difficile diarrhea in hospital in-patients prescribed proton pump inhibitors: cohort and case-control studies. CMAJ 171 (2004) 33-38
41. Fass R., and Sifrim D. Management of heartburn not responding to proton pump inhibitors. Gut 58 (2009) 295-309
42. Dodds W.J., Dent J., Hogan W.J., et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med 307 (1982) 1547-1552
43. Vela M.F., Tutuian R., Katz P.O., and Castell D.O. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther 17 (2003) 243-251
44. Smith P.M., Kerr G.D., Cockel R., et al. A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture. Restore Investigator Group. Gastroenterology 107 (1994) 1312-1318
45. Sharma P., Falk G.W., Sampliner R., et al. Management of nondysplastic Barrett's esophagus: where are we now?. Am J Gastroenterol 104 (2009) 805-808
46. Shaheen N.J., and Richter J.E. Barrett's oesophagus. Lancet 373 (2009) 850-861
47. Hinder R.A., Filipi C.J., Wetscher G., et al. Laparoscopic Nissen fundoplication is an effective treatment for gastroesophageal reflux disease. Ann Surg 220 (1994) 472-481
48. Bammer T., Hinder R.A., Klaus A., et al. Safety and long-term outcome of laparoscopic antireflux surgery in patients in their eighties and older. Surg Endosc 16 (2002) 40-42