Gastric acidity in older adults

JAMA

Volumn 278, Issue 8, 1997, Pages 659-662

  Hurwitz, Aryeh ^a   Brady, Deborah A ^a   Schaal, S Elaine ^a   Samloff, I Michael ^c   Dedon, Jon ^d   Ruhl, Constance E ^a,b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d TRUMAN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HYDROGEN; PEPSINOGEN; PEPSINOGEN I; PEPSINOGEN II; QUININE SULFATE; RESIN;

AGED; ARTICLE; ATROPHIC GASTRITIS; BACTERIAL OVERGROWTH; BREATH ANALYSIS; FEMALE; FLUOROMETRY; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; PREVALENCE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STOMACH ACID; STOMACH PH; TELEMETRY;

EID: 0030771935     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.278.8.659     Document Type: Article

References (40)

1. Holt PR, Rosenberg IAH, Russell RM. Causes and consequences of hypochlorhydria in the elderly. Dig Dis Sci. 1989;34:933-937.
2. Modlin IM, Goldenring JR, Lawton GP, Hunt R. Aspects of the theoretical basis and clinical relevance of low acid states. Am J Gastroenterol. 1994; 89:308-318.
3. Howden CW, Hunt RH. Relationship between gastric secretion and infection. Gut. 1987;28:96-107.
4. Greenblatt DJ, Sellers EM, Shader RI. Drug disposition in old age. N Engl JMed. 1982;306:1081-1088.
5. Goldschmiedt M, Feldman M. Age-related changes in gastric acid secretion. In: Holt PR, Russell RM, eds. Chronic Gastritis and Hypochlorhydria in the Elderly. Boca Raton, Fla: CRC Press Inc; 1993:13-29.
6. Goldschmiedt M, Barnett CC, Schwarz BE, Karnes WE, Redfern JS, Feldman M. Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. Gastroenterology. 1991;101:977-990.
7. Hirschowitz BI, Lanas A. Effect of aging on gastric acid and pepsin secretion: cross-sectional studies in DU and non-DU humans and longitudinal studies in fistula dogs. Gastroenterology. 1992;103:A83.
8. Russell TL, Berardi RR, Barnett JL, et al. Upper gastrointestinal pH in seventy-nine healthy, elderly, North American men and women. Pharm Res. 1993;10:187-196.
9. Collen MJ, Abdulian JD, Chen YK. Age does not affect basal gastric acid secretion in normal subjects or in patients with acid-peptic disease. Am J Gastroenterol. 1994;89:712-716.
10. Feldman M, Cryer B, McArthur KE, Huet BA, Lee E. Effects of aging and gastritis on gastric acid and pepsin secretion in humans: a prospective study. Gastroenterology. 1996;110:1043-1052.
11. Segal HL. Ion exchange resins as a diagnostic tool. Ann N Y Acad Sci. 1953;57:308-323.
12. Ochs HR, Greenblatt DJ, Woo E, Smith TW. Reduced quinidine clearance in elderly persons. Am J Cardiol. 1978;42:481-485.
13. Cramer G, Isaksson B. Quantitative determination of quinidine in plasma. Scand J Clin Lab Invest. 1963;15:553-556.
14. Connell AM. Tubeless testing. In: Connell AM, ed. Clinical Tests of Gastric Function. Springfield, Ill: Charles C Thomas Publisher; 1973:20-30.
15. Dressman JB, Berardi RR, Dermentzoglou LC, et al. Upper gastrointestinal (GI) pH in young, healthy men and women. Pharmaceut Res. 1990;7: 756-761.
16. Samloff IM. Pepsinogens I and II: purification from gastric mucosa and radioimmunoassay in serum. Gastroenterology. 1982;82:26-33.
17. Samloff IM, Varis K, Ihamaki T, Siurala M, Rotter JI. Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. Gastroenterology. 1982;83:204-209.
18. 2 breath tests in patients with small intestine bacterial overgrowth. Gastroenterology. 1986;91: 1447-1451.
19. Kerlin P, Wong L. Breath hydrogen testing in bacterial overgrowth of the small intestine. Gastroenterology. 1988;95:982-988.
20. Zar JH. Biostatistical Analysis. 2nd ed. Englewood Cliffs, NJ: Prentice-Hall International Inc; 1984:380.
21. Holt PR, Russell RM. Introduction. In: Holt PR, Russell RM, eds. Chronic Gastritis and Hypochlorhydria in the Elderly. Boca Raton, Fla: CRC Press; 1993.
22. Savarino V, Mela SG, Scalabrini P, Sumberaz A, Fera G, Celle G. 24-hour study of intragastric acidity in duodenal ulcer patients and normal subjects using continuous intraluminal pH-metry. Dig Dis Sci. 1988;33:1077-1080.
23. Merki HS, Witzel L, Walt RP, et al. Day-to-day variation of 24-hour intragastric acidity. Gastroenterology. 1988;94:887-891.
24. Pounder RE, Fraser AG. Gastric acid secretion and intragastric acidity: measurement in health and disease. Baillieres Clin Gastroenterol. 1993;7:55-80.
25. Blair AJ III, Feldman M, Barnett C, Walsh JH, Richardson CT. Detailed comparison of basal and food-stimulated gastric acid secretion rates and serum gastrin concentrations in duodenal ulcer patients and normal subjects. J Clin Invest. 1987;79: 582-587.
26. Baron JH. Studies of basal and peak acid output with an augmented histamine test. Gut. 1963;4:136-144.
27. Kuna S. The pH of gastric juice in the normal resting stomach. Arch Intern Pharmacodyn. 1964; 151:79-97.
28. Feldman M, Barnett C. Fasting gastric pH and its relationship to true hypochlorhydria in humans. Dig Dis Sci. 1991;36:866-869.
29. Kirsner JB, Bock D, Palmer WL, Levin E, Ford H. Variations in basal gastric secretion in man and the evaluation of gastric secretory stimulants. Gastroenterology. 1956;30:779-789.
30. Johnsen R, Bernersen B, Straume B, Forde O, Bostad L, Burhol PG. Prevalences of endoscopic and histological findings in subjects with and without dyspepsia. BMJ. 1991;302:749-752.
31. Andrews GR, Haneman B, Arnold BJ, Booth JC, Taylor K. Atrophic gastritis in the aged. Aust Ann Med. 1967;16:230-235.
32. Borch K, Axelsson CK, Halgreen H, Nielsen MD, Ledin T, Szesci PB. The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis. Scand J Gastroenterol. 1989;24:870-876.
33. Kekki M, Samloff IM, Varis K, Ihamaki T. Serum pepsinogen I and serum gastrin in the screening of severe atrophic corpus gastritis. Scand J Gastroenterol. 1991;26(suppl 186):109-116.
34. Biemond I, Kreuning J, Jansen JBMJ, Lamers CBHW. Serum pepsinogens in patients with gastric diseases or after gastric surgery. Scand J Gastroenterol. 1994;29:238-242.
35. Krasinski SD, Russell RM, Samloff IM, et al. Fundic atrophic gastritis in an elderly population. J Am Geriatr Soc. 1986;34:800-806.
36. Corazza GR, Menozzi MG, Strocchi A, et al. The diagnosis of small bowel bacterial overgrowth. Gastroenterology. 1990;98:302-309.
37. Saltzman JR, Kowdley KV, Pedrosa MC, et al. Bacterial overgrowth without clinical malabsorption in elderly hypochlorhydric subjects. Gastroenterology. 1994;106:615-623.
38. Husebye E, Skar V, Hoverstad T, Melby K. Fasting hypochlorhydria with gram positive gastric flora is highly prevalent in healthy old people. Gut. 1992;33:1331-1337.
39. Graham DY, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Gastroenterology. 1991;100:1495-1501.
40. Wingo PA, Tong T, Bolden S. Cancer statistics, 1995. CA Cancer J Clin. 1995;45:8-30.