Geldanamycin-induced PCNA degradation in isolated Hsp90 complex from cancer cells

Cancer Investigation

Volumn 28, Issue 6, 2010, Pages 635-641

  Wang, Xing ^a   Heuvelman, Deborah M ^a   Carroll, James A ^a   Dufield, Dawn R ^a   Masferrer, Jaime L ^a  

^a PFIZER INC   (United States)

Author keywords

2 D gel electrophoresis; Colon cancer cells; Geldanamycin; Hsp90; PCNA degradation

Indexed keywords

CYCLINE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90;

ANTIBODY AFFINITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HCT116; CELL STRAIN HT29; COMPLEX FORMATION; CONTROLLED STUDY; DRUG MECHANISM; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SOLID TUMOR;

ADENOSINE TRIPHOSPHATE; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; BINDING SITES; CHROMATOGRAPHY, AFFINITY; COLONIC NEOPLASMS; HCT116 CELLS; HEAD AND NECK NEOPLASMS; HSP90 HEAT-SHOCK PROTEINS; HT29 CELLS; HUMANS; IMMUNOPRECIPITATION; LACTAMS, MACROCYCLIC; MULTIPROTEIN COMPLEXES; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOMICS; UP-REGULATION;

EID: 77953215027     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357901003630983     Document Type: Article

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