Hyperthermia-associated carboplatin resistance: Differential role of p53, HSF1 and Hsp70 in hepatoma cells

Cancer Science

Volumn 101, Issue 5, 2010, Pages 1186-1193

  Sharma, Aanchal ^a   Meena, Avtar Singh ^a   Bhat, Manoj Kumar ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; PROTEIN P53;

ARTICLE; CANCER RESISTANCE; CELL CYCLE; CELL DEATH; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HEAT STRESS; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPERTHERMIA; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANTINEOPLASTIC AGENTS; CARBOPLATIN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; HEAT-SHOCK RESPONSE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LIVER NEOPLASMS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953213774     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2010.01516.x     Document Type: Article

References (37)

1. Harrison LE, Bryan M, Pliner L, Saunders T. Phase I trial of pegylated liposomal doxorubicin with hyperthermic intraperitoneal chemotherapy in patients undergoing cytoreduction for advanced intra-abdominal malignancy. Ann Surg Oncol 2008, 15:1407-13.
2. Sugarbaker PH. Laboratory and clinical basis for hyperthermia as a component of intracavitary chemotherapy. Int J Hyperthermia 2007, 23:431-42.
3. Calderwood SK, Asea A. Targeting HSP70-induced thermotolerance for design of thermal sensitizers. Int J Hyperthermia 2002, 18:597-608.
4. Takayama S, Reed JC, Homma S. Heat-shock proteins as regulators of apoptosis. Oncogene 2003, 22:9041-7.
5. Mosser DD, Morimoto RI. Molecular chaperones and the stress of oncogenesis. Oncogene 2004, 23:2907-18.
6. Ritossa F. A new puffing pattern induced by temperature shock and DNP in drosophila. Cell Mol Life Sci 1962, 18:571-3.
7. Rossi A, Elia G, Santoro MG. Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-kappaB inhibition. J Biol Chem 1998, 273:16446-52.
8. Inouye S, Fujimoto M, Nakamura T. Heat shock transcription factor 1 opens chromatin structure of Interleukin-6 promoter to facilitate binding of an activator or a repressor. J Biol Chem 2007, 282:33210-7.
9. Akerfelt M, Trouillet D, Mezger V, Sistonen L. Heat shock factors at a crossroad between stress and development. Ann N Y Acad Sci 2007, 1113:15-27.
10. Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007, 130:1005-18.
11. Min JN, Huang L, Zimonjic DB, Moskophidis D, Mivechi NF. Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene 2007, 26:5086-97.
12. Westerheide SD, Morimoto RI. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem 2005, 280:33097-100.
13. Rohde M, Daugaard M, Jensen MH, Helin K, Nylandsted J, Jäättelä M. Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev 2005, 19:570-82.
14. Agoff SN, Hou J, Linzer DI, Wu B. Regulation of human hsp70 by p53. Science 1993, 259:84-7.
15. Miyakoda M, Suzuki K, Kodama S, Watanabe M. Activation of ATM and phosphorylation of p53 by heat shock. Oncogene 2007, 21:1090-6.
16. McKay BC, Francis MA, Rainbow AJ. Wildtype p53 is required for heat shock and ultraviolet light enhanced repair of a UV-damaged reporter gene. Carcinogenesis 1997, 18:245-9.
17. Sharma A, Upadhay AK, Bhat MK. Inhibition of Hsp27 and Hsp40 potentiates 5-fluorouracil and carboplatin mediated cell death in hepatoma cells. Cancer Biol Ther 2009, 8:2104-11.
18. Upadhyay AK, Ajay AK, Bhat MK. Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells. Curr Cancer Drug Targets 2008, 8:741-52.
19. Chhipa RR, Bhat MK. Bystander killing of breast cancer MCF-7 cells by MDA-MB-231 cells exposed to 5-fluorouracil is mediated via Fas. J Cell Biochem 2007, 101:68-79.
20. Upadhay AK, Singh S, Chhipa RR, Vijaykumar MV, Ajay AK, Bhat MK. Methyl-β-cyclodextrin enhances the susceptibility of human breast cancer cells to carboplatin and 5-fluorouracil: Involvement of Akt, NF-κB and Bcl-2. Toxicol Appl Pharmacol 2006, 216:177-85.
21. Singh S, Upadhyay AK, Ajay AK. p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis. FEBS Lett 2007, 581:289-95.
22. Singh S, Bhat MK. Carboplatin induces apoptotic cell death through downregulation of constitutively active nuclear factor-kB in human HPV-18 E6-positive HEp-2 cells. Biochem Biophys Res Commun 2004, 318:346-53.
23. Chhipa RR, Kumari R, Upadhyay AK, Bhat MK. Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promoting cell proliferation. Exp Cell Res 2007, 313:3945-58.
24. Mivechi NF, Giaccia AJ. Mitogen-activated protein kinase acts as a negative regulator of the heat shock response in NIH3T3 cells. Cancer Res 1995, 55:5512-9.
25. Ciocca DR, Fuqua SAW, Lock-Lim S, Toft DO, Welch WJ, McGuire WL. Response of human breast cancer cells to heat shock and chemotherapeutic drugs. Cancer Res 1995, 52:3648-54.
26. Choi HS, Lee JH, Park JG, Lee YI. Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex. Biochem Biophys Res Commun 2002, 296:1005-12.
27. Varghese L, Agarwal C, Tyagi A, Singh RP, Agarwal R. Silibinin efficacy against human hepatocellular carcinoma. Clin Cancer Res 2005, 11:8441-8.
28. Iwano S, Shibahara N, Saito T, Kamataki T. Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons. FEBS Lett 2006, 580:890-3.
29. Logan IR, McNeill HV, Cook S. Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage. Nucleic acid Res 2009, 37:2962-73.
30. Rossi A, Ciafre S, Balsamo M, Pierimarchi P, Santor MG. Targeting the heat shock factor 1 by RNA interference: A potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer. Cancer Res 2006, 66:7678-85.
31. de Wit R, van der Zee J, van der Burg ME. A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix. Br J Cancer 1999, 80:1387-91.
32. de Bree E, Rosing H, Filis D. Cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy with paclitaxel: a clinical and pharmacokinetic study. Ann Surg Oncol 2008, 15:1183-92.
33. Müller L, Schaupp A, Walerych D, Wegele H, Buchner J. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. J Biol Chem 2004, 279:48846-54.
34. Quenneville LA, Trotter MJ, Maeda T, Tron VA. p53-dependent regulation of heat shock protein 72. Br J Dermatol 2002, 146:786-91.
35. Komarova EA, Neznanov N, Komarov PG, Chernov MV, Wang K, Gudkov AV. p53 inhibitor pifithrin α can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem 2003, 18:15465-8.
36. Li Q, Feldman RA, Radhakrishnan VM, Carey S, Martinez JD. Hsf1 is required for the nuclear translocation of p53 tumor suppressor. Neoplasia 2008, 10:1138-45.
37. Luft JC, Benjamin IJ, Mestril R, Dix DJ. Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest. Cell Stress Chaperones 2001, 6:326-36.