Serotonin receptor 3A expression in normal and neoplastic B cells

Pathobiology

Volumn 77, Issue 3, 2010, Pages 129-135

  Rinaldi, Andrea ^a   Chiaravalli, Anna Maria ^b   Mian, Michael ^a   Zucca, Emanuele ^a   Tibiletti, Maria Grazia ^b   Capella, Carlo ^b   Bertoni, Francesco ^a  

^a ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^b UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

5 Hydroxytryptamine receptor 3A; Chromosome 11; Lymphoma

Indexed keywords

SEROTONIN 3A RECEPTOR;

ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CHROMOSOME 11Q; CONTROLLED STUDY; FOLLICULAR LYMPHOMA; GENE EXPRESSION; GENE IDENTIFICATION; GENE MAPPING; GENE OVEREXPRESSION; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMAN TISSUE; LARGE CELL LYMPHOMA; LYMPHOMA; MANTLE CELL LYMPHOMA; PRIORITY JOURNAL;

B-LYMPHOCYTES; BIOPSY; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 11; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA, FOLLICULAR; LYMPHOMA, LARGE B-CELL, DIFFUSE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, SEROTONIN, 5-HT3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77953207562     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000292646     Document Type: Article

References (34)

1. Barth TF, Dohner H, Werner CA, Stilgenbauer S, Schlotter M, Pawlita M, Lichter P, Moller P, Bentz M: Characteristic pattern of chromosomal gains and losses in primary large B-cell lymphomas of the gastrointestinal tract. Blood 1998; 91: 4321-4330.
2. Chan WY, Wong N, Chan AB, Chow JH, Lee JC: Consistent copy number gain in chromosome 12 in primary diffuse large cell lymphomas of the stomach. Am J Pathol 1998; 152: 11-16.
3. Rickert CH, Dockhorn-Dworniczak B, Simon R, Paulus W: Chromosomal imbalances in primary lymphomas of the central nervous system. Am J Pathol 1999; 155: 1445-1451.
4. Starostik P, Patzner J, Greiner A, Schwarz S, Kalla J, Ott G, Muller-Hermelink HK: Gastric marginal zone B-cell lymphomas of malt type develop along 2 distinct pathogenetic pathways. Blood 2002; 99: 3-9.
5. Zhu Y, Monni O, Franssila K, Elonen E, Vilpo J, Joensuu H, Knuutila S: Deletions at 11q23 in different lymphoma subtypes. Haematologica 2000; 85: 908-912.
6. Stilgenbauer S, Winkler D, Ott G, Schaffner C, Leupolt E, Bentz M, Moller P, Muller-Hermelink HK, James MR, Lichter P, Dohner H: Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma. Blood 1999; 94: 3262-3264.
7. Monni O, Zhu Y, Franssila K, Oinonen R, Hoglund P, Elonen E, Joensuu H, Knuutila S: Molecular characterization of deletion at 11q22.1-23.3 in mantle cell lymphoma. Br J Haematol 1999; 104: 665-671.
8. Bertoni F, Conconi A, Cogliatti SB, Schmitz SF, Ghielmini M, Cerny T, Fey M, Pichert G, Bertolini F, Ponzoni M, Baldini L, Jones C, Auer R, Zucca E, Cavalli F, Cotter FE: Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss group for clinical cancer research. Br J Haematol 2004; 124: 289-298.
9. Kobayashi H, Espinosa R 3rd, Thirman MJ, Davis EM, Diaz MO, Le Beau MM, Rowley JD: Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization. Blood 1993; 81: 3027-3033. (Pubitemid 23162122)
10. Auer RL, Starczynski J, McElwaine S, Bertoni F, Newland AC, Fegan CD, Cotter FE: Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. Genes Chromosomes Cancer 2005; 43: 1-10.
11. Kalla C, Scheuermann MO, Kube I, Schlotter M, Mertens D, Dohner H, Stilgenbauer S, Lichter P: Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B. Eur J Cancer 2007; 43: 1328-1335.
12. Akao Y, Seto M, Yamamoto K, Iida S, Nakazawa S, Inazawa J, Abe T, Takahashi T, Ueda R: The RCK gene associated with t(11; 14) translocation is distinct from the MLL/ALL-1 gene with t(4; 11) and t(11; 19) translocations. Cancer Res 1992; 52: 6083-6087.
13. Rovigatti U, Watson DK, Yunis JJ: Amplification and rearrangement of Hu-ets-1 in leukemia and lymphoma with involvement of 11q23. Science 1986; 232: 398-400.
14. Zhao C, Inoue J, Imoto I, Otsuki T, Iida S, Ueda R, Inazawa J: POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17. Oncogene 2008; 27: 63-75.
15. Schaffner C, Stilgenbauer S, Rappold GA, Dohner H, Lichter P: Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. Blood 1999; 94: 748-753.
16. Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR: Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 2002; 8: 68-74.
17. Klein U, Tu Y, Stolovitzky GA, Mattioli M, Cattoretti G, Husson H, Freedman A, Inghirami G, Cro L, Baldini L, Neri A, Califano A, Dalla-Favera R: Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 2001; 194: 1625-1638.
18. Kuppers R, Klein U, Schwering I, Distler V, Brauninger A, Cattoretti G, Tu Y, Stolovitzky GA, Califano A, Hansmann ML, Dalla-Favera R: Identification of Hodgkin and Reed- Sternberg cell-specific genes by gene expression profiling. J Clin Invest 2003; 111: 529-537.
19. Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, De Leval L, Kurtin P, Dal Cin P, Ladd C, Feuerhake F, Aguiar RC, Li S, Salles G, Berger F, Jing W, Pinkus GS, Habermann T, Dalla-Favera R, Harris NL, Aster JC, Golub TR, Shipp MA: The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin's lymphoma. Blood 2003; 102: 3871-3879.
20. Lacrima K, Valentini A, Lambertini C, Taborelli M, Rinaldi A, Zucca E, Catapano C, Cavalli F, Gianella-Borradori A, Maccallum DE, Bertoni F: In vitro activity of cyclindependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas. Ann Oncol 2005; 16: 1169-1176.
21. Lacrima K, Rinaldi A, Vignati S, Martin V, Tibiletti MG, Gaidano G, Catapano C, Bertoni F: Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B cell lymphomas. Leu Lymphoma 2007; 48: 158-167.
22. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, IARC Press, 2001.
23. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, Falini B, Banham AH, Rosenwald A, Staudt LM, Connors JM, Armitage JO, Chan WC: Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004; 103: 275-282.
24. Klein U, Tu Y, Stolovitzky GA, Keller JL, Haddad J Jr, Miljkovic V, Cattoretti G, Califano A, Dalla-Favera R: Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci USA 2003; 100: 2639-2644.
25. Ek S, Hogerkorp CM, Dictor M, Ehinger M, Borrebaeck CA: Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells. Cancer Res 2002; 62: 4398-4405.
26. Thompson AJ, Lummis SC: The 5-HT3 receptor as a therapeutic target. Expert Opin Ther Targets 2007; 11: 527-540.
27. Farber L, Haus U, Spath M, Drechsler S: Physiology and pathophysiology of the 5- HT3 receptor. Scand J Rheumatol Suppl 2004; 119: 2-8.
28. Fiebich BL, Akundi RS, Seidel M, Geyer V, Haus U, Muller W, Stratz T, Candelario-Jalil E: Expression of 5-HT3A receptors in cells of the immune system. Scand J Rheumatol Suppl 2004; 119: 9-11.
29. Vega Lde L, Munoz E, Calzado MA, Lieb K, Candelario-Jalil E, Gschaidmeir H, Farber L, Mueller W, Stratz T, Fiebich BL: The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol 2005; 70: 369-380.
30. Khan NA, Poisson JP: 5-HT3 receptor-channels coupled with Na + influx in human T cells: role in T cell activation. J Neuroimmunol 1999; 99: 53-60.
31. Khan NA, Hichami A: Ionotrophic 5-hydroxytryptamine type 3 receptor activates the protein kinase C-dependent phospholipase d pathway in human T-cells. Biochem J 1999; 344: 199-204.
32. Iken K, Cheng S, Fargin A, Goulet AC, Kouassi E: Serotonin upregulates mitogenstimulated B lymphocyte proliferation through 5-HT1A receptors. Cell Immunol 1995; 163: 1-9.
33. Choquet D, Korn H: Dual effects of serotonin on a voltage-gated conductance in lymphocytes. Proc Natl Acad Sci USA 1988; 85: 4557-4561.
34. Serafeim A, Holder MJ, Grafton G, Chamba A, Drayson MT, Luong QT, Bunce CM, Gregory CD, Barnes NM, Gordon J: Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. Blood 2003; 101: 3212-3219.