Adverse effects of topical nonsteroidal antiinflammatory drugs in older adults with osteoarthritis: A systematic literature review

Journal of Rheumatology

Volumn 37, Issue 6, 2010, Pages 1236-1243

  Makris, Una E ^a   Kohler, Minna J ^a   Fraenkel, Liana ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Adverse effects; Aged; Nonsteroidal antiinflammatory agents; Osteoarthritis; Topical administration

Indexed keywords

ARNICA MONTANA EXTRACT; CELECOXIB; DICLOFENAC; ELTENAC; FELBINAC; IBUPROFEN; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PIROXICAM; PLACEBO; PROTON PUMP INHIBITOR; SALICYLIC ACID METHYL ESTER; UNCLASSIFIED DRUG; WARFARIN;

ABDOMINAL PAIN; ADVERSE DRUG REACTION; ANEMIA; APPLICATION SITE ERYTHEMA; APPLICATION SITE IRRITATION; APPLICATION SITE PARESTHESIA; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; DERMATITIS; DIARRHEA; DIZZINESS; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG ERUPTION; DRUG INDUCED HEADACHE; DRUG POTENTIATION; DRUG SAFETY; DRUG WITHDRAWAL; DRY SKIN; DYSPEPSIA; GASTRITIS; GASTROINTESTINAL HEMORRHAGE; GROUPS BY AGE; HALITOSIS; HUMAN; KIDNEY DISEASE; LIVER FUNCTION; NAUSEA; OSTEOARTHRITIS; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SIDE EFFECT; SYSTEMATIC REVIEW; URTICARIA; VERTIGO; VESICULOBULLOUS RASH;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIRHEUMATIC AGENTS; DATABASES, BIBLIOGRAPHIC; FEMALE; GASTROINTESTINAL DISEASES; HEALTH STATUS; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEVERITY OF ILLNESS INDEX;

EID: 77953204736     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: 10.3899/jrheum.090935     Document Type: Article

References (52)

1. Dawson J, Linsell L, Zondervan K, Rose P, Randall T, Carr A, et al. Epidemiology of hip and knee pain and its impact on overall health status in older adults. Rheumatology 2004;43:497-504.
2. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001;60:91-97
3. Felson DT. The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Semin Arthritis Rheum 1990;20:42-50.
4. Bellamy N, Kirwan J, Boers M, Brooks P, Strand V, Tugwell P, et al. Recommendations for a core set of outcome measures for future phase III clinical trials in knee, hip, and hand osteoarthritis. Consensus development at OMERACT III. J Rheumatol 1997;24:799-802. (Pubitemid 27146105)
5. Bateman DN, Kennedy JG. Non-steroidal anti-inflammatory drugs and elderly patients. BMJ 1995;310:817-818
6. Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 2008;16:137-162
7. American Academy of Orthopaedic Surgeons: Treatment of osteoarthritis of the knee (non-arthroplasty). [Internet. Accessed February 19, 2010.] Available from: http://www.aaos.org/Research/guidelines/GuidelineOAKnee.asp
8. Dickson DJ. A double-blind evaluation of topical piroxicam gel with oral ibuprofen in osteoarthritis of the knee. Curr Ther Res Clin Exp 1991;49:199-207.
9. Rother M, Lavins BJ, Kneer W, Lehnhardt K, Seidel EJ, Mazgareanu S. Efficacy and safety of epicutaneous ketoprofen in Transfersome (IDEA-033) versus oral celecoxib and placebo in osteoarthritis of the knee: multicentre randomised controlled trial. Ann Rheum Dis 2007;66:1178-1183
10. Tugwell PS, Wells GA, Shainhouse JZ. Equivalence study of a topical diclofenac solution (Pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial. J Rheumatol 2004;31:2002-2012
11. Sandelin J, Harilainen A, Crone H, Hamberg P, Forsskahl B, Tamelander G. Local NSAID gel (Eltenac) in the treatment of osteoarthritis of the knee. A double blind study comparing Eltenac with oral diclofenac and placebo gel. Scand J Rheumatol 1997;26:287-292 (Pubitemid 27390759)
12. Underwood M, Ashby D, Cross P, Hennessy E, Letley L, Martin J, et al. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. BMJ 2008;336:138-142
13. Simon LS, Grierson LM, Naseer Z, Bookman AA, Zev Shainhouse J. Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis. Pain 2009;143:238-245
14. Fraenkel L, Wittink DR, Concato J, Fried T. Informed choice and the widespread use of antiinflammatory drugs. Arthritis Rheum 2004;51:210-214
15. Andrews PA, Sampson SA. Topical non-steroidal drugs are systemically absorbed and may cause renal disease. Nephrol Dial Transpl 1999;14:187-189
16. Garcia Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994;343:769-772
17. Langman MJ, Weil J, Wainwright P, Lawson DH, Rawlins MD, Logan RF, et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994;343:1075-1078 (Pubitemid 124000864)
18. Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta-analysis. Ann Intern Med 1991;115:787-796
19. Jick H, Derby LE, Garcia Rodriguez LA, Jick SS, Dean AD. Liver disease associated with diclofenac, naproxen, and piroxicam. Pharmacotherapy 1992;12:207-212
20. Ophaswongse S, Maibach H. Topical nonsteroidal anti-inflammatory drugs: allergic and photoallergic contact dermatitis and phototoxicity. Contact Dermatitis 1993;29:57-64. (Pubitemid 23226501)
21. Zimmerman J, Siguencia J, Tsvang E. Upper gastrointestinal hemorrhage associated with cutaneous application of diclofenac gel. Am J Gastroenterol 1995;90:2032-2034
22. Evans JMM, MacDonald TM. Tolerability of topical NSAIDs in the elderly - Do they really convey a safety advantage? Drug Aging 1996;9:101-108
23. Evans JM, McMahon AD, McGilchrist MM, White G, Murray FE, McDevitt DG, et al. Topical non-steroidal anti-inflammatory drugs and admission to hospital for upper gastrointestinal bleeding and perforation: a record linkage case-control study. BMJ 1995;311:22-26
24. Baer PA, Thomas LM, Shainhouse Z. Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial. BMC Musculoskelet Disord 2005;6:44.
25. Bookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004;171:333-338
26. Bruhlmann P, Michel BA. Topical diclofenac patch in patients with knee osteoarthritis: a randomized, double-blind, controlled clinical trial. Clin Exp Rheumatol 2003;21:193-198 (Pubitemid 36519562)
27. Chow WH, Cheung KL, Ling HM, See T. Potentiation of warfarin anticoagulation by topical methylsalicylate ointment. J R Soc Med 1989;82:501-502 (Pubitemid 19191228)
28. Cooper SM, Shaw S. Contact allergy to isopropanolamine in Traxam® gel. Contact Dermatitis 1999;41:233-234 (Pubitemid 29427928)
29. Dreiser RL, Tisne-Camus M. DHEP plasters as a topical treatment of knee osteoarthritis - a double-blind placebo-controlled study. Drug Exp Clin Res 1993;19:117-123 (Pubitemid 24000678)
30. Grace D, Rogers J, Skeith K, Anderson K. Topical diclofenac versus placebo: a double blind, randomized clinical trial in patients with osteoarthritis of the knee. J Rheumatol 1999;26:2659-2663
31. Niethard FU, Gold MS, Solomon GS, Liu J-M, Unkauf M, Albrecht HH, et al. Efficacy of topical diclofenac diethylamine gel in osteoarthritis of the knee. J Rheumatol 2005;32:2384-2392 (Pubitemid 41780652)
32. Ottillinger B, Gomor B, Michel BA, Pavelka K, Beck W, Elsasser U. Efficacy and safety of Eltenac gel in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 2001;9:273-280
33. Roth SH, Shainhouse JZ. Efficacy and safety of a topical diclofenac solution (Pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial. Arch Intern Med 2004;164:2017-2023
34. Waikakul S, Penkitti P, Soparat K, Boonsanong W. Topical analgesics for knee arthrosis: A parallel study of ketoprofen gel and diclofenac emulgel. J Med Assoc Thailand 1997;80:593-597 (Pubitemid 27513357)
35. Widrig R, Suter A, Saller R, Melzer J. Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study. Rheumatol Int 2007;27:585-591
36. Yip AS, Chow WH, Tai YT, Cheung KL. Adverse effect of topical methylsalicylate ointment on warfarin anticoagulation: an unrecognized potential hazard. Postgrad Med J 1990;66:367-369
37. Altman RD, Dreiser RL, Fisher CL, Chase WF, Dreher DS, Zacher J. Diclofenac sodium gel in patients with primary hand osteoarthritis: a randomized, double-blind, placebo-controlled trial. J Rheumatol 2009;36:1991-1999
38. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12.
39. Mason L, Moore RA, Edwards JE, Derry S, McQuay HJ. Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis. BMC Musculoskelet Disord 2004;5:28.
40. Mason L, Moore RA, Edwards JE, Derry S, McQuay HJ. Topical NSAIDs for acute pain: a meta-analysis. BMC Fam Pract 2004;5:10.
41. Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay HJ. Quantitive systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 1998;316:333-338 (Pubitemid 28121255)
42. Zacher J, Altman R, Bellamy N, Bruhlmann P, Da Silva J, Huskisson E, et al. Topical diclofenac and its role in pain and inflammation: an evidence-based review. Curr Med Res Opin 2008;24:925-950
43. Towheed TE. Pennsaid® therapy for osteoarthritis of the knee: A systematic review and metaanalysis of randomized controlled trials. J Rheumatol 2006;33:567-573 (Pubitemid 43334582)
44. Touma Z, Chen L, Arayssi T. Topical nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis. Future Rheumatol 2007;2:163-175
45. Petersen B, Rovati S. Diclofenac epolamine (Flector) patch: evidence for topical activity. Clin Drug Investig 2009;29:1-9.
46. Novartis. Prescribing information for Voltaren Gel (diclofenac sodium topical gel). 2007.
47. Rainsford KD, Kean WF, Ehrlich GE. Review of the pharmaceutical properties and clinical effects of the topical NSAID formulation, diclofenac epolamine. Curr Med Res Opin 2008;24:2967-2992
48. Rochon PA, Fortin PR, Dear KB, Minaker KL, Chalmers TC. Reporting of age data in clinical trials of arthritis. Deficiencies and solutions. Arch Intern Med 1993;153:243-248
49. Liberopoulos G, Trikalinos NA, Ioannidis JP. The elderly were under-represented in osteoarthritis clinical trials. J Clin Epidemiol 2009;62:1218-1223
50. Diaz RL, Gardeazabal J, Manrique P, Raton JA, Urrutia I, Rodriguez-Sasiain JM, et al. Greater allergenicity of topical ketoprofen in contact dermatitis confirmed by use. Contact Dermatitis 2006;54:239-243
51. Kneer W, Rother I, Rother M, Seidel E. A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation. Curr Drug Saf 2009;4:5-10.
52. Vandenbroucke JP, Psaty BM. Benefits and risks of drug treatments: how to combine the best evidence on benefits with the best data about adverse effects. JAMA 2008;300:2417-2419