메뉴 건너뛰기




Volumn 28, Issue 6, 2010, Pages 588-597

P16 modulates VEGF expression via its interaction with HIF-1α in breast cancer cells

Author keywords

Breast cancer; HIF 1a; P16; VEGF

Indexed keywords

ADENOVIRUS VECTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN P16; VASCULOTROPIN;

EID: 77953196949     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357900903286941     Document Type: Article
Times cited : (34)

References (46)
  • 1
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D.; Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86, 353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 2
    • 0033119833 scopus 로고    scopus 로고
    • Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
    • Grunstein, J.; Roberts, W.G.; Mathieu-Costello, O.; Hanahan, D.; Johnson, R.S. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res 1999, 59, 1592-1598.
    • (1999) Cancer Res , vol.59 , pp. 1592-1598
    • Grunstein, J.1    Roberts, W.G.2    Mathieu-Costello, O.3    Hanahan, D.4    Johnson, R.S.5
  • 3
    • 0033874137 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas
    • Detmar, M.; Velasco, P.; Richard, L.; Claffey, K.P.; Streit, M.; Riccardi, L.; Skobe, M.; Brown, L.F. Expression of vascular endothelial growth factor induces an invasive phenotype in human squamous cell carcinomas. Am J Pathol 2000, 156, 159-167.
    • (2000) Am J Pathol , vol.156 , pp. 159-167
    • Detmar, M.1    Velasco, P.2    Richard, L.3    Claffey, K.P.4    Streit, M.5    Riccardi, L.6    Skobe, M.7    Brown, L.F.8
  • 4
    • 0030059451 scopus 로고    scopus 로고
    • What, if anything, is an angiogenic factor?
    • Risau, W. What, if anything, is an angiogenic factor? Cancer Metastasis Rev 1996, 15, 149-151.
    • (1996) Cancer Metastasis Rev , vol.15 , pp. 149-151
    • Risau, W.1
  • 5
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld. G.; Cohen, T.; Gengrinovitch, S.; Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999, 13, 9-22.
    • (1999) FASEB J , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 6
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger, D.R.; Galli, S.J.; Dvorak, A.M.; Perruzzi, C.A.; Harvey, V.S.; Dvorak, H.F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983, 219, 983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 7
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara, N.; Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989, 16, 851-858.
    • (1989) Biochem Biophys Res Commun , vol.16 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 9
    • 0029935566 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer
    • Yoshiji, H.; Gomez, D.E.; Shibuya, M.; Thorgeirsson, U.P. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res 1996, 56, 2013-2016.
    • (1996) Cancer Res , vol.56 , pp. 2013-2016
    • Yoshiji, H.1    Gomez, D.E.2    Shibuya, M.3    Thorgeirsson, U.P.4
  • 10
    • 0016218630 scopus 로고
    • Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
    • Liotta, L.A.; Kleinerman, J.; Saidel, G.M. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res 1974, 4, 997-1004.
    • (1974) Cancer Res , vol.4 , pp. 997-1004
    • Liotta, L.A.1    Kleinerman, J.2    Saidel, G.M.3
  • 11
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of human primary tumors in mice
    • O'Reilly, M.S.; Holmgren, L.; Chen, C.; Folkman. J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nature Med 1996, 2, 689-692.
    • (1996) Nature Med , vol.2 , pp. 689-692
    • O'Reilly, M.S.1    Holmgren, L.2    Chen, C.3    Folkman, J.4
  • 12
    • 0037064201 scopus 로고    scopus 로고
    • Sitedirected mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain
    • Michel, G.; Minet, E.; Mottet, D.; Remacle, J.; Michiels, C. Sitedirected mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain. Biochim Biophys Acta 2002, 1578, 73-83.
    • (2002) Biochim Biophys Acta , vol.1578 , pp. 73-83
    • Michel, G.1    Minet, E.2    Mottet, D.3    Remacle, J.4    Michiels, C.5
  • 13
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J.A.; Jiang, B.H.; Iyer, N.V.; Agani, F.; Leung, S.W.; Koos, R.D.; Semenza, G.L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996, 16, 4604-4613.
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 14
    • 1642576082 scopus 로고    scopus 로고
    • The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Roth, U.; Curth, K.; Unterman, T.G.; Kietzmann, T. The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2004, 279, 2623-2631.
    • (2004) J Biol Chem , vol.279 , pp. 2623-2631
    • Roth, U.1    Curth, K.2    Unterman, T.G.3    Kietzmann, T.4
  • 15
    • 0033178714 scopus 로고    scopus 로고
    • Restoration of wild type p16 downregulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas
    • Harada, H.; Nakagawa, K.; Iwata, S.; et al. Restoration of wild type p16 downregulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas. Cancer Res 1999, 59, 3783-3789.
    • (1999) Cancer Res , vol.59 , pp. 3783-3789
    • Harada, H.1    Nakagawa, K.2    Iwata, S.3
  • 16
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza, G.L. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 2004, 19, 176-182.
    • (2004) Physiology (Bethesda) , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 17
    • 0035958932 scopus 로고    scopus 로고
    • The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits HIF-1-mediated transcription
    • Fatyol, K.; Szalay, A.A. The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits HIF-1-mediated transcription. J Biol Chem 2001, 276, 28421-28429.
    • (2001) J Biol Chem , vol.276 , pp. 28421-28429
    • Fatyol, K.1    Szalay, A.A.2
  • 18
    • 33846652552 scopus 로고    scopus 로고
    • Hypoxiainducible factor-1 alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression
    • Liao, D.; Corle, C.; Seagroves, T.N.; Johnson, R.S. Hypoxiainducible factor-1 alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 2007, 67, 563-572.
    • (2007) Cancer Res , vol.67 , pp. 563-572
    • Liao, D.1    Corle, C.2    Seagroves, T.N.3    Johnson, R.S.4
  • 19
    • 34249340478 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer
    • Hiraga, T.; Kizaka-Kondoh, S.; Hirota, K.; Hiraoka, M.; Yoneda, T. Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res 2007, 67, 4157-4163.
    • (2007) Cancer Res , vol.67 , pp. 4157-4163
    • Hiraga, T.1    Kizaka-Kondoh, S.2    Hirota, K.3    Hiraoka, M.4    Yoneda, T.5
  • 20
    • 0032889698 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis
    • Dvorak, H.F.; Nagy; J.A.; Feng, D.; et al. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol 1999, 237, 97-132. (Pubitemid 28554861)
    • (1999) Current Topics in Microbiology and Immunology , vol.237 , pp. 97-132
    • Dvorak, H.F.1    Nagy, J.A.2    Feng, D.3    Brown, L.F.4    Dvorak, A.M.5
  • 21
    • 35248814408 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in cancer
    • Maynard, M.A.; Ohh, M. The role of hypoxia-inducible factors in cancer. Cell Mol Life Sci 2007, 64, 2170-2180.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 2170-2180
    • Maynard, M.A.1    Ohh, M.2
  • 23
    • 0029091503 scopus 로고
    • High frequency of homozygous deletion at p16/CDKN2 in primary human tumors
    • Cairns, P.; Polascik, T.J.; Eby, Y.; Sidransky, D. High frequency of homozygous deletion at p16/CDKN2 in primary human tumors. Nature Genet 1995, 11, 210-212.
    • (1995) Nature Genet , vol.11 , pp. 210-212
    • Cairns, P.1    Polascik, T.J.2    Eby, Y.3    Sidransky, D.4
  • 24
    • 0034821460 scopus 로고    scopus 로고
    • Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gall bladder cancer
    • Quan, Z.W.; Wu, K.; Wang, J.; Shi, W.; Zhang, Z.; Merrell, R.C. Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gall bladder cancer. J Am Coll Surg 2001, 193, 380-383.
    • (2001) J Am Coll Surg , vol.193 , pp. 380-383
    • Quan, Z.W.1    Wu, K.2    Wang, J.3    Shi, W.4    Zhang, Z.5    Merrell, R.C.6
  • 25
    • 0034115639 scopus 로고    scopus 로고
    • Adenoviral vector containing wild type p16 suppresses prostate cancer growth and prolongs survival by inducing cell senescence
    • Steiner, M.S.; Zhang, Y.; Farooq, F.; Lerner, J.; Wang, Y.; Lu, Y. Adenoviral vector containing wild type p16 suppresses prostate cancer growth and prolongs survival by inducing cell senescence. Cancer Gene Ther 2000, 7, 360-372.
    • (2000) Cancer Gene Ther , vol.7 , pp. 360-372
    • Steiner, M.S.1    Zhang, Y.2    Farooq, F.3    Lerner, J.4    Wang, Y.5    Lu, Y.6
  • 27
    • 0034095488 scopus 로고    scopus 로고
    • A fast way to generate recombinant adenovirus: A high-frequency- recombination system
    • Steiner, M.S.; Zhang, Y.; Lu, Y. A fast way to generate recombinant adenovirus: a high-frequency-recombination system. J Industr Microbiol Biotechnol 2000, 24, 198-202.
    • (2000) J Industr Microbiol Biotechnol , vol.24 , pp. 198-202
    • Steiner, M.S.1    Zhang, Y.2    Lu, Y.3
  • 28
    • 0002025785 scopus 로고
    • Gene transfer and expression protocols
    • E.J. Murray (ed.). Totowa, NJ: Humana Press
    • Graham, F.L.; Prevec, L. Gene transfer and expression protocols. In Methods in Molecular Biology. E.J. Murray (ed.). Totowa, NJ: Humana Press, 1991, 109-128.
    • (1991) Methods in Molecular Biology , pp. 109-128
    • Graham, F.L.1    Prevec, L.2
  • 29
    • 0028801736 scopus 로고
    • Co-expression of galectin-1 and its complementary glycoconjugates laminin and lysosome-associated membrane proteins in murine PCC4.Aza1R embryonal carcinoma cells induced to differentiation by butyrate
    • Lu, Y.; Whitaker, L.L.; Li, X.; Lotan, D.; Lotan, R. Co-expression of galectin-1 and its complementary glycoconjugates laminin and lysosome-associated membrane proteins in murine PCC4.aza1R embryonal carcinoma cells induced to differentiation by butyrate. Mol Cell Differ 1995, 3, 175-191.
    • (1995) Mol Cell Differ , vol.3 , pp. 175-191
    • Lu, Y.1    Whitaker, L.L.2    Li, X.3    Lotan, D.4    Lotan, R.5
  • 30
    • 0032823875 scopus 로고    scopus 로고
    • Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteine
    • Liu, M.; Wikonkal, N.M.; Brash, D.E. Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteine. Carcinogenesis 1999, 20, 1869-1872.
    • (1999) Carcinogenesis , vol.20 , pp. 1869-1872
    • Liu, M.1    Wikonkal, N.M.2    Brash, D.E.3
  • 31
    • 0027201773 scopus 로고
    • Induction of vascular endothelial tubular morphogenesis by human glioma cells: A model system for tumor angiogenesis
    • Abe, T.; Okamura, K.; Ono, M.; Kohno, K.; Mori, T.; Hori, S.; Kuwano, M. Induction of vascular endothelial tubular morphogenesis by human glioma cells: a model system for tumor angiogenesis. J Clin Invest 1993, 92, 54-61.
    • (1993) J Clin Invest , vol.92 , pp. 54-61
    • Abe, T.1    Okamura, K.2    Ono, M.3    Kohno, K.4    Mori, T.5    Hori, S.6    Kuwano, M.7
  • 32
    • 34547107592 scopus 로고    scopus 로고
    • Hypoxia-driven selection of the metastatic phenotype
    • Sullivan, R.; Graham, C.H. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev 2007, 26, 319-331.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 319-331
    • Sullivan, R.1    Graham, C.H.2
  • 33
    • 34547125574 scopus 로고    scopus 로고
    • Hypoxia, gene expression, and metastasis
    • Chan, D.A.; Giaccia, A.J. Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 2007, 26, 333-339.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 333-339
    • Chan, D.A.1    Giaccia, A.J.2
  • 34
    • 0037279517 scopus 로고    scopus 로고
    • The hypoxic tumour microenvironment and metastatic progression
    • Subarsky, P.; Hill, R.P. The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 2003, 20, 237-250.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 237-250
    • Subarsky, P.1    Hill, R.P.2
  • 35
    • 1542405875 scopus 로고    scopus 로고
    • Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma
    • Cairns, R.A.; Hill, R.P. Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma. Cancer Res 2004, 64, 2054-2061.
    • (2004) Cancer Res , vol.64 , pp. 2054-2061
    • Cairns, R.A.1    Hill, R.P.2
  • 36
    • 0028215744 scopus 로고
    • Benign-tomalignant B16 melanoma progression induced in two stages in vitro by exposure to hypoxia
    • Stackpole, C.W.; Groszek, L.; Kalbag, S.S. Benign-tomalignant B16 melanoma progression induced in two stages in vitro by exposure to hypoxia. J Natl Cancer Inst 1994, 86, 361-367.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 361-367
    • Stackpole, C.W.1    Groszek, L.2    Kalbag, S.S.3
  • 37
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003, 3, 721-32.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 38
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel, M.; Vaupel, P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001, 93, 266-276.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 39
    • 0030821453 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) in human breast cancer: Correlation with disease-free survival
    • Obermair, A.; Kucera, E.; Mayerhofer, K.; et al. Vascular endothelial growth factor (VEGF) in human breast cancer: correlation with disease-free survival. Int J Cancer 1997, 74, 455-458.
    • (1997) Int J Cancer , vol.74 , pp. 455-458
    • Obermair, A.1    Kucera, E.2    Mayerhofer, K.3
  • 40
    • 0031032073 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma
    • Gasparini, G.; Toi, M.; Gion, M.; et al. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst 1997, 89, 139-144.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 139-144
    • Gasparini, G.1    Toi, M.2    Gion, M.3
  • 42
    • 0032101647 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 gene transfer downregulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer
    • Bouvet, M.; Ellis, L.M.; Nishizaki, M.; et al. Adenovirus-mediated wild-type p53 gene transfer downregulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res 1998, 58, 2288-2292.
    • (1998) Cancer Res , vol.58 , pp. 2288-2292
    • Bouvet, M.1    Ellis, L.M.2    Nishizaki, M.3
  • 43
    • 0035863470 scopus 로고    scopus 로고
    • RB2/p130 geneenhanced expression down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in vivo
    • Claudio, P.P.; Stiegler, P.; Howard, C.M.; et al. RB2/p130 geneenhanced expression down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in vivo. Cancer Res 2001, 61, 462-468.
    • (2001) Cancer Res , vol.61 , pp. 462-468
    • Claudio, P.P.1    Stiegler, P.2    Howard, C.M.3
  • 44
    • 0037414180 scopus 로고    scopus 로고
    • YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
    • Yeo, E.J.; Ahn, M.; Jung, K.; et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 2003, 95, 516-525.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 516-525
    • Yeo, E.J.1    Ahn, M.2    Jung, K.3
  • 45
    • 10744231706 scopus 로고    scopus 로고
    • 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
    • Mabjeesh, N.J.; Escuin, D.; LaVallee, T.M.; et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003, 3, 363-375.
    • (2003) Cancer Cell , vol.3 , pp. 363-375
    • Mabjeesh, N.J.1    Escuin, D.2    LaVallee, T.M.3
  • 46
    • 65749092211 scopus 로고    scopus 로고
    • Nm23, breast differentiation, and cancer metastasis
    • A.M. Bowcock (ed.). Totowa, NJ: Humana Press
    • Steeg, P.S.; Hartsough, M.T.; Clare, S.E. Nm23, breast differentiation, and cancer metastasis. In Breast Cancer, A.M. Bowcock (ed.). Totowa, NJ: Humana Press, 1998, 267-283.
    • (1998) Breast Cancer , pp. 267-283
    • Steeg, P.S.1    Hartsough, M.T.2    Clare, S.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.