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Volumn 13, Issue 5, 2010, Pages 332-345

Intedanib, a triple kinase inhibitor of VEGFR, FGFR and PDGFR for the treatment of cancer and idiopathic pulmonary fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; FIBROBLAST GROWTH FACTOR RECEPTOR; INTEDANIB; PACLITAXEL; PEMETREXED; PLACEBO; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

EID: 77953195426     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (31)

References (75)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Tumor angiogenesis: Therapeutic implications. Folkman J N Engl J Med 1971 285 21 1182-1186
    • (1971) Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.N.1
  • 2
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Wood JM, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, Hofmann F, Mestan J, Mett H, O'Reilly T, Persohn E et al Cancer Res 2000 60 8 2178-2189
    • (2000) Cancer Res , vol.60 , Issue.8 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3    Cozens, R.4    Ferrari, S.5    Frei, J.6    Hofmann, F.7    Mestan, J.8    Mett, H.9    O'Reilly, T.10    Persohn, E.11
  • 3
    • 0023885305 scopus 로고
    • The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
    • The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Hanks SA, Quinn AM, Hunter T Science1988. 241,42-52
    • (1988) Science , vol.241 , pp. 42-52
    • Hanks, S.A.1    Quinn, A.M.2    Hunter, T.3
  • 4
    • 77953215026 scopus 로고    scopus 로고
    • FDA approves Avastin, a targeted therapy for first-line metastatic colorectal cancer patients. Genentech Inc Press Release2004 February 26
    • FDA approves Avastin, a targeted therapy for first-line metastatic colorectal cancer patients. Genentech Inc Press Release2004 February 26
  • 5
    • 77953216459 scopus 로고    scopus 로고
    • EORTC-NCI-AACR - 16th Symposium (Part II) - OVERNIGHT REPORT, Molecular Targets and Cancer Therapeutics, Geneva, Switzerland. Lunec A IDDB MEETINGREPORT 2004 September 28 - October 1
    • EORTC-NCI-AACR - 16th Symposium (Part II) - OVERNIGHT REPORT, Molecular Targets and Cancer Therapeutics, Geneva, Switzerland. Lunec A IDDB MEETINGREPORT 2004 September 28 - October 1
  • 6
    • 77953184830 scopus 로고    scopus 로고
    • A clinical phase I dose escalation, pharmacokinetic (PK) and pharmacodynamic (PD) study of BIBF 1120 in advanced cancer patients Abs 135
    • A clinical phase I dose escalation, pharmacokinetic (PK) and pharmacodynamic (PD) study of BIBF 1120 in advanced cancer patients. Mross K, Baas F, Medinger M, Drevs J, Stecker R, Hennig J, Wolters M, Stehle G, Stefanic M EJC Suppl 2004 2 8 Abs 135
    • (2004) EJC Suppl , vol.28
    • Mross, K.1    Baas, F.2    Medinger, M.3    Drevs, J.4    Stecker, R.5    Hennig, J.6    Wolters, M.7    Stehle, G.8    Stefanic, M.9
  • 9
    • 77953189586 scopus 로고    scopus 로고
    • In vitro and in vivo efficacy of BIBF,1120, a small molecule triple angiokinase inhibitor Abs A19
    • In vitro and in vivo efficacy of BIBF 1120, a small molecule triple angiokinase inhibitor. Hilberg F, Brandsetter I, Roth GJ ClinCancer Res 2005 11 23 Suppl Abs A19
    • (2005) ClinCancer Res , vol.11 , Issue.23 SUPPL.
    • Hilberg, F.1    Brandsetter, I.2    Roth, G.J.3
  • 10
    • 77953218840 scopus 로고    scopus 로고
    • BIBF 1120, a small molecule triple angiokinase inhibitor, affects the tumor vasculature in human tumor xenografts on nude mice as detected by DCE-MRI Abs A22
    • BIBF 1120, a small molecule triple angiokinase inhibitor, affects the tumor vasculature in human tumor xenografts on nude mice as detected by DCE-MRI. Krssk M, Kriz M, Stefanic M, Hilberg F ClinCancer Res 2005 11 23 Suppl Abs A22
    • (2005) ClinCancer Res , vol.11 , Issue.23 SUPPL.
    • Krssk, M.1    Kriz, M.2    Stefanic, M.3    Hilberg, F.4
  • 11
    • 77953191908 scopus 로고    scopus 로고
    • Safety, pharmakokinetics and pharmacodynamics (DCE-MRI) in patients with metastatic colorectal cancer treated in a phase I study with BIBF 1120, the first triple angiokinase inhibitor Abs A1
    • Safety, pharmakokinetics and pharmacodynamics (DCE-MRI) in patients with metastatic colorectal cancer treated in a phase I study with BIBF 1120, the first triple angiokinase inhibitor. Mross K, Strecker R, Frost A, Unger C, Hennig J, Stefanic M, Stopfer P, Deichsel G, Stehle G, de Rossi L ClinCancer Res 2005 11 23 Suppl Abs A1
    • (2005) ClinCancer Res , vol.11 , Issue.23 SUPPL.
    • Mross, K.1    Strecker, R.2    Frost, A.3    Unger, C.4    Hennig, J.5    Stefanic, M.6    Stopfer, P.7    Deichsel, G.8    Stehle, G.9    De Rossi, L.10
  • 12
    • 77953215292 scopus 로고    scopus 로고
    • Pharmacokinetics of an oral VEGF receptor tyrosine kinase inhibitor (PTK787/ZK222584) in patients with myelodysplastic syndrome (MDS): Cancer and Leukemia Group B Study 10105 Abs 6573
    • Pharmacokinetics of an oral VEGF receptor tyrosine kinase inhibitor (PTK787/ZK222584) in patients with myelodysplastic syndrome (MDS): Cancer and Leukemia Group B Study 10105. Gupta P, Miller AA, Owzar K, Murry DJ, Sanford BL, Vij R, Yu D, Hasserjian RP, Larson RA, Ratain MJ J CLIN ONCOL2006 24 18 Suppl Abs 6573
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Gupta, P.1    Miller, A.A.2    Owzar, K.3    Murry, D.J.4    Sanford, B.L.5    Vij, R.6    Yu, D.7    Hasserjian, R.P.8    Larson, R.A.9    Ratain, M.J.10
  • 13
    • 77953192174 scopus 로고    scopus 로고
    • A phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) given continuously to patients with advanced solid tumours, incorporating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) Abs 3015
    • A phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) given continuously to patients with advanced solid tumours, incorporating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Lee CP, Taylor NJ, Attard G, Nathan PD, De Bono JS, Temple G, Tang A, Padhani AR, Judson IR, Rustin GJ J ClinOncol 2006 24 18 Suppl Abs 3015
    • (2006) J ClinOncol , vol.24 , Issue.18 SUPPL.
    • Lee, C.P.1    Taylor, N.J.2    Attard, G.3    Nathan, P.D.4    De Bono, J.S.5    Temple, G.6    Tang, A.7    Padhani, A.R.8    Judson, I.R.9    Rustin, G.J.10
  • 14
    • 77953219687 scopus 로고    scopus 로고
    • FDA approves Avastin in combination with chemotherapy for first-line treatment of most common type of lung cancer, Genentech Inc Press Release2006 October 11
    • FDA approves Avastin in combination with chemotherapy for first-line treatment of most common type of lung cancer. Genentech Inc Press Release2006 October 11
  • 15
    • 33846244201 scopus 로고    scopus 로고
    • Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors
    • Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors. Kulimova E, Oelmann E, Bisping G, Bisping J, Mesters RM, Schwable J, Hilberg F, Roth GJ, Munzert G, Stefanic M, Steffen B et al Mol Cancer Ther 2006 5 12 3105-3112
    • (2006) Mol Cancer Ther , vol.5 , Issue.12 , pp. 3105-3112
    • Kulimova, E.1    Oelmann, E.2    Bisping, G.3    Bisping, J.4    Mesters, R.M.5    Schwable, J.6    Hilberg, F.7    Roth, G.J.8    Munzert, G.9    Stefanic, M.10    Steffen, B.11
  • 16
    • 77953189585 scopus 로고    scopus 로고
    • A phase I study of BMS-582664 (brivanib alaninate), an oral dual inhibitor of VEGFR and FGFR tyrosine kinases, in patients (pts) with advanced/metastatic solid tumors: Safety, pharmacokinetic (PK), and pharmacodynamic (PD) findings Abs 3559
    • A phase I study of BMS-582664 (brivanib alaninate), an oral dual inhibitor of VEGFR and FGFR tyrosine kinases, in patients (pts) with advanced/metastatic solid tumors: Safety, pharmacokinetic (PK), and pharmacodynamic (PD) findings. Jonker DJ, Rosen LS, Sawyer M, Wilding G, Noberasco C, Jayson G, Rustin G, McArthur G, Velasquez L, Galbraith S J ClinOncol 2007 25 18 Suppl Abs 3559
    • (2007) J ClinOncol , vol.25 , Issue.18 SUPPL.
    • Jonker, D.J.1    Rosen, L.S.2    Sawyer, M.3    Wilding, G.4    Noberasco, C.5    Jayson, G.6    Rustin, G.7    McArthur, G.8    Velasquez, L.9    Galbraith, S.10
  • 17
    • 77953188743 scopus 로고    scopus 로고
    • A phase I dose escalation and pharmacokinetic study of BIBF 1120 in combination with paclitaxel and carboplatin in patients with advanced gynecological malignancies Abs 3561
    • A phase I dose escalation and pharmacokinetic study of BIBF 1120 in combination with paclitaxel and carboplatin in patients with advanced gynecological malignancies. Harter P, Huober J, Pfisterer J, Wimberger P, Loibl S, Stopfer P, Kaiser R, Reichardt V, du Bois A J CLIN ONCOL2007 25 18 Suppl Abs 3561
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Harter, P.1    Huober, J.2    Pfisterer, J.3    Wimberger, P.4    Loibl, S.5    Stopfer, P.6    Kaiser, R.7    Reichardt, V.8    Du Bois, A.9
  • 18
    • 77953223061 scopus 로고    scopus 로고
    • A double blind phase II study of BIBF 1,120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC) Abs 7635
    • A double blind phase II study of BIBF 1,120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC). Von Pawel J, Kaiser R, Eschbach C, Stefanic M, Love J, Gatzemeier U, Reck M J CLIN ONCOL2007 25 18 Suppl Abs 7635
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Von Pawel, J.1    Kaiser, R.2    Eschbach, C.3    Stefanic, M.4    Love, J.5    Gatzemeier, U.6    Reck, M.7
  • 20
    • 77953193012 scopus 로고    scopus 로고
    • Avastin approved in Europe for first line treatment of women with metastatic breast cancer. Roche Holding AG Press Release2007 March 29
    • Avastin approved in Europe for first line treatment of women with metastatic breast cancer. Roche Holding AG Press Release2007 March 29
  • 21
    • 77953190121 scopus 로고    scopus 로고
    • Industry's highest growth rate recorded twice in 2 years: NBI. Pharma Jpn2007 2037 April, 16, 3
    • Industry's highest growth rate recorded twice in 2 years: NBI. Pharma Jpn2007 2037 April 16 3
  • 22
    • 77953203932 scopus 로고    scopus 로고
    • NCT00514683: Safety and efficacy of BIBF 1120 in idiopathic pulmonary fibrosis. Boehringer Ingelheim Pharmaceuticals clinicaltrials.gov 2007, August, 10
    • NCT00514683: Safety and efficacy of BIBF 1120 in idiopathic pulmonary fibrosis. Boehringer Ingelheim Pharmaceuticals clinicaltrials.gov 2007 August 10
  • 23
    • 77953177909 scopus 로고    scopus 로고
    • AstraZeneca provides update on RECENTINTM clinical development programme. AstraZeneca plc PRESSRELEASE 2008 February 27
    • AstraZeneca provides update on RECENTINTM clinical development programme. AstraZeneca plc PRESSRELEASE 2008 February 27
  • 24
    • 77953176237 scopus 로고    scopus 로고
    • Boehringer Ingelheim annual press conference, 2008. Boehringer Ingelheim Corp Company Presentation2008 April 08
    • Boehringer Ingelheim annual press conference 2008. Boehringer Ingelheim Corp Company Presentation2008 April 08
  • 25
    • 77953204217 scopus 로고    scopus 로고
    • Data suggests promising overall survival and progression-free survival with Vargatef (BIBF 1120). Boehringer Ingelheim Corp Press Release2008 April 28
    • Data suggests promising overall survival and progression-free survival with Vargatef (BIBF 1120). Boehringer Ingelheim Corp Press Release2008 April 28
  • 27
    • 77953210888 scopus 로고    scopus 로고
    • Pharmacokinetic (PK) analysis of a phase I study of continuous oral treatment with the angiokinase inhibitor BIBF 1120, in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer (NSCLC) Abs 3567
    • Pharmacokinetic (PK) analysis of a phase I study of continuous oral treatment with the angiokinase inhibitor BIBF 1120, in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer (NSCLC). Camidge DR, Conkling P, Stephenson JJ, Glassman PM, Zhao Y, Kaiser R, Stopfer P J CLIN ONCOL2008 26 15 Suppl Abs 3567
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Camidge, D.R.1    Conkling, P.2    Stephenson, J.J.3    Glassman, P.M.4    Zhao, Y.5    Kaiser, R.6    Stopfer, P.7
  • 28
  • 30
  • 31
    • 77953224443 scopus 로고    scopus 로고
    • NCT00706628: A multi-centre 3-arm randomised phase II trial of BIBF 1120 versus BIBW-2992 versus sequential administration of BIBF 1120 and BIBW-2992 in patients with hormone-resistant prostate cancer
    • NCT00706628: A multi-centre 3-arm randomised phase II trial of BIBF 1120 versus BIBW-2992 versus sequential administration of BIBF 1120 and BIBW-2992 in patients with hormone-resistant prostate cancer. Boehringer Ingelheim Pharmaceuticals clinicaltrials.gov 2006
    • (2006) Boehringer Ingelheim Pharmaceuticals Clinicaltrials.gov
  • 32
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy. Gschwind A, Fischer OM, Ullrich A NatRev Cancer2004, 4, 5,361-370
    • (2004) NatRev Cancer , vol.4 , Issue.5 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 33
    • 77953213372 scopus 로고    scopus 로고
    • First pivotal trials begin for Boehringer Ingelheim's novel triple angiokinase inhibitor vargatef (BIBF 1120). Boehringer Ingelheim Corp Press Release2008 November 17
    • First pivotal trials begin for Boehringer Ingelheim's novel triple angiokinase inhibitor vargatef (BIBF 1120). Boehringer Ingelheim Corp Press Release2008 November 17
  • 34
    • 77953222781 scopus 로고    scopus 로고
    • Amgen Takeda and Millennium provide update on phase 3 trial of motesanib in patients with non-small cell lung cancer. Amgen Inc; Takeda Pharmaceutical Co Ltd PRESSRELEASE, 2008 November, 19
    • Amgen, Takeda and Millennium provide update on phase 3 trial of motesanib in patients with non-small cell lung cancer. Amgen Inc; Takeda Pharmaceutical Co Ltd PRESSRELEASE 2008 November 19
  • 35
    • 84979863733 scopus 로고    scopus 로고
    • Pharmacokinetics of BIBF 1120 after administration of single doses of 100 mg [14C]-BIBF 1120
    • Pharmacokinetics of BIBF 1120 after administration of single doses of 100 mg [14C]-BIBF 1120. Stopfer P, Rathgen K, Liesener A, Gaschler-Markefski B, Kaiser R ANN ONCOL2008 19 Suppl,8,158-159
    • (2008) Ann Oncol , vol.19 , Issue.8 SUPPL. , pp. 158-159
    • Stopfer, P.1    Rathgen, K.2    Liesener, A.3    Gaschler-Markefski, B.4    Kaiser, R.5
  • 36
    • 77953180665 scopus 로고    scopus 로고
    • Pfizer discontinues global phase III trial of axitinib for futility in advanced pancreatic cancer. Pfizer Inc PRESSRELEASE 2009, January, 30
    • Pfizer discontinues global phase III trial of axitinib for futility in advanced pancreatic cancer. Pfizer Inc PRESSRELEASE 2009 January 30
  • 38
    • 77953185928 scopus 로고    scopus 로고
    • A randomized phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer (OC) Abs 5501
    • A randomized phase II placebo-controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer (OC). Ledermann JA, Rustin GJ, Hackshaw A, Kaye SB, Jayson G, Gabra H, James LE, Bell S, Temple G J CLIN ONCOL2009 27 15 Suppl Abs 5501
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Ledermann, J.A.1    Rustin, G.J.2    Hackshaw, A.3    Kaye, S.B.4    Jayson, G.5    Gabra, H.6    James, L.E.7    Bell, S.8    Temple, G.9
  • 39
    • 77953226940 scopus 로고    scopus 로고
    • Phase I clinical and biomarker study of BIBF 1120, an oral multitarget tyrosine kinase inhibitor, in patients with advanced solid tumors (ST): Impact of CD133- and CD117-positive cells on a biomarker of an antiangiogenic inhibitor Abs 3572
    • Phase I clinical and biomarker study of BIBF 1120, an oral multitarget tyrosine kinase inhibitor, in patients with advanced solid tumors (ST): Impact of CD133- and CD117-positive cells on a biomarker of an antiangiogenic inhibitor. Okamoto I, Kaneda H, Satoh T, Okamoto W, Terashima M, Arao T, Nishio K, Nakagawa K, Konishi K, Kaiser R J CLIN ONCOL2009 27 15 Suppl Abs 3572
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Okamoto, I.1    Kaneda, H.2    Satoh, T.3    Okamoto, W.4    Terashima, M.5    Arao, T.6    Nishio, K.7    Nakagawa, K.8    Konishi, K.9    Kaiser, R.10
  • 40
    • 77953196694 scopus 로고    scopus 로고
    • An open-label phase II study of first and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC) Abs 4577
    • An open-label phase II study of first and second-line treatment with brivanib in patients with hepatocellular carcinoma (HCC). Raoul JL, Finn RS, Kang YK, Park JW, Harris R, Coric V, Donica M, Walters I J CLIN ONCOL2009 27 15 Suppl Abs 4577
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Raoul, J.L.1    Finn, R.S.2    Kang, Y.K.3    Park, J.W.4    Harris, R.5    Coric, V.6    Donica, M.7    Walters, I.8
  • 42
    • 77953223935 scopus 로고    scopus 로고
    • NCT00806819: Lume lung 2: BIBF 1120 plus pemetrexed compared to placebo plus pemetrexed in 2nd line nonsquamous NSCLC. Boehringer Ingelheim Pharmaceuticals clinicaltrials.gov, 2009
    • NCT00806819: Lume lung 2: BIBF 1120 plus pemetrexed compared to placebo plus pemetrexed in 2nd line nonsquamous NSCLC. Boehringer Ingelheim Pharmaceuticals clinicaltrials.gov 2009
  • 43
    • 77953207714 scopus 로고    scopus 로고
    • European Commission approves broader label for Avastin allowing combination with docetaxel for the first-linetreatment of advanced (metastatic) breast cancer. Roche Holding AG Press Release2009 July 29
    • European Commission approves broader label for Avastin allowing combination with docetaxel for the first-linetreatment of advanced (metastatic) breast cancer. Roche Holding AG Press Release2009 July 29
  • 45
    • 77953228865 scopus 로고    scopus 로고
    • A phase II double-blind study to investigate efficacy and safety of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small cell lung cancer Abs P1.236
    • A phase II double-blind study to investigate efficacy and safety of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small cell lung cancer. Reck M, Kaiser R, Eschbach C, Stefanie M, Love J, Staab A, Freiwald M, Bruno R, Stopfer P, Gatzemeier U, von Pawel J J ThoracicOncol 2009 4 9 Suppl 1 Abs P1.236
    • (2009) J ThoracicOncol , vol.4 , Issue.9 SUPPL. 1
    • Reck, M.1    Kaiser, R.2    Eschbach, C.3    Stefanie, M.4    Love, J.5    Staab, A.6    Freiwald, M.7    Bruno, R.8    Stopfer, P.9    Gatzemeier, U.10    Von Pawel, J.11
  • 46
    • 77953183182 scopus 로고    scopus 로고
    • FDA approves new treatment for advanced form of kidney cancer. The Food and Drug Administration Press Release2009 October 19
    • FDA approves new treatment for advanced form of kidney cancer. The Food and Drug Administration Press Release2009 October 19
  • 47
    • 77953184829 scopus 로고    scopus 로고
    • Astrazeneca withdraws regulatory submissions for Zactima (vandetanib) in combination with chemotherapy for advanced NSCLC. AstraZeneca plc PRESSRELEASE 2009, October 28
    • Astrazeneca withdraws regulatory submissions for Zactima (vandetanib) in combination with chemotherapy for advanced NSCLC. AstraZeneca plc PRESSRELEASE 2009 October 28
  • 49
    • 77953217733 scopus 로고    scopus 로고
    • Antitumor activity of a novel angiogenesis inhibitor BIBF 1120 for hepatocellular carcinoma and a new pharmacodynamic biomarker in blood samples
    • Antitumor activity of a novel angiogenesis inhibitor BIBF 1120 for hepatocellular carcinoma and a new pharmacodynamic biomarker in blood samples. Kudo M, Kudo K, Arao T, Nishio K HEPATOLOGY2009 50 Suppl 4 1099A
    • (2009) Hepatology , vol.50 , Issue.4 SUPPL.
    • Kudo, M.1    Kudo, K.2    Arao, T.3    Nishio, K.4
  • 50
    • 77953219958 scopus 로고    scopus 로고
    • Boehringer Ingelheim initiates first phase III clinical trial in ovarian cancer. Boehringer Ingelheim Corp Press Release2009 December 17
    • Boehringer Ingelheim initiates first phase III clinical trial in ovarian cancer. Boehringer Ingelheim Corp Press Release2009 December 17
  • 51
    • 77953180943 scopus 로고    scopus 로고
    • Phase I dose-escalation study of continuous oral treatment with the angiokinase inhibitor BIBF 1120 in patients with advanced solid tumors
    • Phase I dose-escalation study of continuous oral treatment with the angiokinase inhibitor BIBF 1120 in patients with advanced solid tumors. Kaneda H, Okamoto I, Satoh T, Arao T, Nishio K, Sarashina A, Konishi K, Stopfer P, Kaiser R, Nakagawa K EJC Suppl 2009 7 2 133
    • (2009) EJC Suppl , vol.7 , Issue.2 , pp. 133
    • Kaneda, H.1    Okamoto, I.2    Satoh, T.3    Arao, T.4    Nishio, K.5    Sarashina, A.6    Konishi, K.7    Stopfer, P.8    Kaiser, R.9    Nakagawa, K.10
  • 52
    • 77953205016 scopus 로고    scopus 로고
    • Pharmacokinetic (PK) analysis of two dosing schedules of the angiokinase inhibitor BIBF 1120 in patients with hormone- refractory prostate cancer (HRPC) who progressed after docetaxel treatment Abs 14578
    • Pharmacokinetic (PK) analysis of two dosing schedules of the angiokinase inhibitor BIBF 1120 in patients with hormone- refractory prostate cancer (HRPC) who progressed after docetaxel treatment. Droz JP, Flechon A, Joly F, de Mont-Serrat H, Kaiser R, Stopfer P, Oudard S J CLIN ONCOL2008 26 15 Suppl Abs 14578
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Droz, J.P.1    Flechon, A.2    Joly, F.3    De Mont-Serrat, H.4    Kaiser, R.5    Stopfer, P.6    Oudard, S.7
  • 53
    • 77953198321 scopus 로고    scopus 로고
    • AstraZeneca development pipeline, 28 January 2010. AstraZeneca plc COMPANYWORLDWIDE WEB SITE 2010 January 28
    • AstraZeneca development pipeline, 28 January 2010. AstraZeneca plc COMPANYWORLDWIDE WEB SITE 2010 January 28
  • 54
    • 77951895481 scopus 로고    scopus 로고
    • A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies
    • A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies. Du Bois A, Huober J, Stopfer P, Pfisterer J, Wimberger P, Loibl S, Reichardt VL, Harter P AnnOncol 2010 21 2 370-375
    • (2010) AnnOncol , vol.21 , Issue.2 , pp. 370-375
    • Du Bois, A.1    Huober, J.2    Stopfer, P.3    Pfisterer, J.4    Wimberger, P.5    Loibl, S.6    Reichardt, V.L.7    Harter, P.8
  • 56
    • 45849085389 scopus 로고    scopus 로고
    • Quantitative mapping of hepatic perfusion index using MR imaging: A potential reproducible tool for assessing tumour response to treatment with the antiangiogenic compound BIBF 1120, a potent triple angiokinase inhibitor
    • Quantitative mapping of hepatic perfusion index using MR imaging: A potential reproducible tool for assessing tumour response to treatment with the antiangiogenic compound BIBF 1120, a potent triple angiokinase inhibitor. Miyazaki K, Collins DJ, Walker-Samuel S, Taylor JN, Padhani AR, Leach MO, Koh DM Eur Radiol 2008 18 7 1414-1421
    • (2008) Eur Radiol , vol.18 , Issue.7 , pp. 1414-1421
    • Miyazaki, K.1    Collins, D.J.2    Walker-Samuel, S.3    Taylor, J.N.4    Padhani, A.R.5    Leach, M.O.6    Koh, D.M.7
  • 57
    • 51549109927 scopus 로고    scopus 로고
    • Targeting the endothelin pathway in the idiopathic pulmonary fibrosis: The role of bosentan.
    • Targeting the endothelin pathway in the idiopathic pulmonary fibrosis: The role of bosentan. Antoniu SA EXPERT OPIN THERTARGETS2008 12 9 1077-1084
    • (2008) Expert Opin Thertargets , vol.12 , Issue.9 , pp. 1077-1084
    • Antoniu, S.A.1
  • 58
    • 77950688983 scopus 로고    scopus 로고
    • Anti-angiogenic tyrosine kinase inhibitors: What is their mechanism of action?
    • Anti-angiogenic tyrosine kinase inhibitors: What is their mechanism of action? Gotink KJ, Verheul HM Angiogenesis 2010 13 1 1-14
    • (2010) Angiogenesis , vol.13 , Issue.1 , pp. 1-14
    • Gotink, K.J.1    Verheul, H.M.2
  • 59
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Tumor angiogenesis. Kerbel RS N Engl J Med 2008 358 19 2039-2049
    • (2008) Engl J Med , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel Rs, N.1
  • 61
    • 76149087441 scopus 로고    scopus 로고
    • Antiangiogenic agents and vascular disrupting agents for the treatment of lung cancer: A review
    • Antiangiogenic agents and vascular disrupting agents for the treatment of lung cancer: A review. Clement-Duchene C, Wakelee H J ThoracOncol 2010 5 1 129-139
    • (2010) J ThoracOncol , vol.5 , Issue.1 , pp. 129-139
    • Clement-Duchene, C.1    Wakelee, H.2
  • 62
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Casanovas O, Hicklin DJ, Bergers G, Hanahan D Cancer Cell 2005 8 4 299-309
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 64
    • 66449098872 scopus 로고    scopus 로고
    • VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats
    • VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. Farkas L, Farkas D, Ask K, Moller A, Gauldie J, Margetts P,Inman M, Kolb M J ClinInvest2009 119 5 1298-1311
    • (2009) J ClinInvest , vol.119 , Issue.5 , pp. 1298-1311
    • Farkas, L.1    Farkas, D.2    Ask, K.3    Moller, A.4    Gauldie, J.5    Margetts, P.6    Inman, M.7    Kolb, M.8
  • 65
    • 77953224442 scopus 로고    scopus 로고
    • Pharmacokinetic (PK) analysis of a phase I trial investigating continuous treatment with the angiokinase inhibitor BIBF 1120 combined with pemetrexed in previously treated patients with non-small cell lung cancer (NSCLC) Abs 14511
    • Pharmacokinetic (PK) analysis of a phase I trial investigating continuous treatment with the angiokinase inhibitor BIBF 1120 combined with pemetrexed in previously treated patients with non-small cell lung cancer (NSCLC). Hanna NH, Zhao Y, Kaiser R, Stopfer P, Gyorffy S Ellis PM J CLIN ONCOL2008 26 15 Suppl Abs 14511
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Hanna, N.H.1    Zhao, Y.2    Kaiser, R.3    Stopfer, P.4    Gyorffy, S.5    Ellis, P.M.6
  • 67
    • 77953223359 scopus 로고    scopus 로고
    • Angiogenesis inhibition in cancer therapy: Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: Biological functions and role in malignancy.
    • Angiogenesis inhibition in cancer therapy: Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: Biological functions and role in malignancy. Appelmann I, Liersch R, Kessler T, Mesters RM, Berdel WE RECENT RESULTSCANCERRES2010 180 51-81
    • (2010) Recent Resultscancerres , vol.180 , pp. 51-81
    • Appelmann, I.1    Liersch, R.2    Kessler, T.3    Mesters, R.M.4    Berdel, W.E.5
  • 68
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: From development to cancer
    • Fibroblast growth factor signalling: From development to cancer. Turner N, Grose R NatRev Cancer 2010 10 116-129
    • (2010) NatRev Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 71
    • 77953206902 scopus 로고    scopus 로고
    • Efficacy of BIBF 1120, a potent triple angiokinase inhibitor, in models of human non-small cell lung cancer is augmented by chemotherapy
    • Efficacy of BIBF 1120, a potent triple angiokinase inhibitor, in models of human non-small cell lung cancer is augmented by chemotherapy. Hilberg F, Brandstetter I J THORACIC ONCOL2007 2 8 S380
    • (2007) J Thoracic Oncol , vol.2 , Issue.8
    • Hilberg, F.1    Brandstetter, I.2
  • 72
    • 77953190689 scopus 로고    scopus 로고
    • An open label randomized phase ii study of oral triple angiokinase inhibitor BIBF 1120 in hormone refractory prostate cancer (HRPC) patients who progressed after docetaxel
    • An open label randomized phase ii study of oral triple angiokinase inhibitor BIBF 1120 in hormone refractory prostate cancer (HRPC) patients who progressed after docetaxel. Oudard S, Chevreau C, Flechon A, Gunzer K, Houede N, Krakowski I, de Mont-Serrat H, Rouyrre N, Kaiser R, Droz JP EJC SUPPL2007 5 4 280
    • (2007) EJC Suppl , vol.5 , Issue.4 , pp. 280
    • Oudard, S.1    Chevreau, C.2    Flechon, A.3    Gunzer, K.4    Houede, N.5    Krakowski, I.6    De Mont-Serrat, H.7    Rouyrre, N.8    Kaiser, R.9    Droz, J.P.10
  • 74
    • 77953178486 scopus 로고    scopus 로고
    • NCT01004003: Phase I/II comparison of efficacy and safety of BIBF 1120 and sorafenib in patients with advanced hepatocellular carcinoma, Boehringer Ingelheim Corp CLINICALTRIALS.GOV2009
    • NCT01004003: Phase I/II comparison of efficacy and safety of BIBF 1120 and sorafenib in patients with advanced hepatocellular carcinoma. Boehringer Ingelheim Corp CLINICALTRIALS.GOV2009
  • 75
    • 77953190120 scopus 로고    scopus 로고
    • NCT01024920: Compare safety and efficacy of BIBF 1120 versus sunitinib, Boehringer Ingelheim Corp CLINICALTRIALS.GOV2009
    • NCT01024920: Compare safety and efficacy of BIBF 1120 versus sunitinib. Boehringer Ingelheim Corp CLINICALTRIALS.GOV2009


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