메뉴 건너뛰기




Volumn 15, Issue 3, 2010, Pages 209-217

Renin-angiotensin-aldosterone system (RAAS) pharmacogenomics: Implications in heart failure management

Author keywords

ACE inhibitors; Aldosterone antagonists; Angiotensin receptor blockers; Pharmacogenetics; Pharmacogenomics; Renin angiotensin aldosterone System

Indexed keywords

ALDOSTERONE ANTAGONIST; ALDOSTERONE SYNTHASE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANGIOTENSINOGEN; BENAZEPRIL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRADYKININ B2 RECEPTOR; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; LOSARTAN; MINERALOCORTICOID RECEPTOR; PERINDOPRIL; RENIN; SPIRONOLACTONE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN RECEPTOR; ANTIHYPERTENSIVE AGENT;

EID: 77953182003     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10741-008-9092-z     Document Type: Review
Times cited : (9)

References (42)
  • 1
    • 77956884598 scopus 로고    scopus 로고
    • Hospitalization in the United States, AHRQ Publication No. 00-0031, May. Agency for Healthcare Research and Quality, Rockville, MD
    • Hospitalization in the United States (1997) HCUP Fact Book No 1. AHRQ Publication No. 00-0031, May 2000. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/data/hcup/factbk1
    • (1997) HCUP Fact Book No 1
  • 2
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    • Cohn JN, Tognoni G (2001) A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 345(23):1667-1675
    • (2001) N Engl J Med , vol.345 , Issue.23 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 3
    • 0041408235 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: The CHARM-added trial
    • DOI 10.1016/S0140-6736(03)14283-3
    • McMurray JJ, Ostergren J, Swedberg K, Granger CB, Held P, Michelson EL et al (2003) Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARMAdded trial. Lancet 362(9386):767-771 (Pubitemid 37093916)
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 767-771
    • McMurray, J.J.V.1    Ostergren, J.2    Swedberg, K.3    Granger, C.B.4    Held, P.5    Michelson, E.L.6    Olofsson, B.7    Yusuf, S.8    Pfeffer, M.A.9
  • 4
    • 0242490542 scopus 로고    scopus 로고
    • Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    • Pfeffer MA, McMurray JJ, Velazquez EJ, Rouleau JL, Kober L, Maggioni AP et al (2003) Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 349(20):1893-1906
    • (2003) N Engl J Med , vol.349 , Issue.20 , pp. 1893-1906
    • Ma, P.1    McMurray, J.J.2    Velazquez, E.J.3    Rouleau, J.L.4    Kober, L.5    Maggioni, A.P.6
  • 5
    • 33746806364 scopus 로고    scopus 로고
    • Pharmacogenetics of chronic cardiovascular drugs: Applications and implications
    • Zineh I, Johnson JA (2006) Pharmacogenetics of chronic cardiovascular drugs: applications and implications. Expert Opin Pharmacother 7(11):1417-1427
    • (2006) Expert Opin Pharmacother , vol.7 , Issue.11 , pp. 1417-1427
    • Zineh, I.1    Johnson, J.A.2
  • 6
    • 0025165779 scopus 로고
    • An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels
    • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F (1990) An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86(4):1343-1346
    • (1990) J Clin Invest , vol.86 , Issue.4 , pp. 1343-1346
    • Rigat, B.1    Hubert, C.2    Alhenc-Gelas, F.3    Cambien, F.4    Corvol, P.5    Soubrier, F.6
  • 7
    • 0027419508 scopus 로고
    • Angiotensin I-converting enzyme in human circulating mononuclear cells: Genetic polymorphism of expression in Tlymphocytes
    • Costerousse O, Allegrini J, Lopez M, Alhenc-Gelas F (1993) Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in Tlymphocytes. Biochem J 290(Pt 1):33-40
    • (1993) Biochem J , vol.290 , Issue.PART 1 , pp. 33-40
    • Costerousse, O.1    Allegrini, J.2    Lopez, M.3    Alhenc-Gelas, F.4
  • 8
    • 0026675062 scopus 로고
    • Deletion polymorphism in the gene for angiotensinconverting enzyme is a potent risk factor for myocardial infarction
    • Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D et al (1992) Deletion polymorphism in the gene for angiotensinconverting enzyme is a potent risk factor for myocardial infarction. Nature 359(6396):641-644
    • (1992) Nature , vol.359 , Issue.6396 , pp. 641-644
    • Cambien, F.1    Poirier, O.2    Lecerf, L.3    Evans, A.4    Cambou, J.P.5    Arveiler, D.6
  • 11
    • 0030893575 scopus 로고    scopus 로고
    • A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro
    • Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M et al (1997) A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 99(7):1786-1797
    • (1997) J Clin Invest , vol.99 , Issue.7 , pp. 1786-1797
    • Inoue, I.1    Nakajima, T.2    Williams, C.S.3    Quackenbush, J.4    Puryear, R.5    Powers, M.6
  • 12
    • 0035147118 scopus 로고    scopus 로고
    • Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinct
    • Martin MM, Willardson BM, Burton GF, White CR, McLaughlin JN, Bray SM et al (2001) Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinct. Mol Endocrinol 15(2):281-293
    • (2001) Mol Endocrinol , vol.15 , Issue.2 , pp. 281-293
    • Martin, M.M.1    Willardson, B.M.2    Burton, G.F.3    White, C.R.4    McLaughlin, J.N.5    Bray, S.M.6
  • 13
    • 0032726402 scopus 로고    scopus 로고
    • Analysis and functional characterization of alternatively spliced angiotensin II type 1 and 2 receptor transcripts in the human heart
    • Warnecke C, Surder D, Curth R, Fleck E, Regitz-Zagrosek V (1999) Analysis and functional characterization of alternatively spliced angiotensin II type 1 and 2 receptor transcripts in the human heart. J Mol Med 77(10):718-727
    • (1999) J Mol Med , vol.77 , Issue.10 , pp. 718-727
    • Warnecke, C.1    Surder, D.2    Curth, R.3    Fleck, E.4    Regitz-Zagrosek, V.5
  • 14
    • 34047227863 scopus 로고    scopus 로고
    • Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits
    • Abdollahi MR, Lewis RM, Gaunt TR, Cumming DV, Rodriguez S, Rose-Zerilli M et al (2007) Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Hum Mutat 28(4):365-373
    • (2007) Hum Mutat , vol.28 , Issue.4 , pp. 365-373
    • Abdollahi, M.R.1    Lewis, R.M.2    Gaunt, T.R.3    Cumming, D.V.4    Rodriguez, S.5    Rose-Zerilli, M.6
  • 15
    • 0031019956 scopus 로고    scopus 로고
    • Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency
    • Lung CC, Chan EK, Zuraw BL (1997) Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency. J Allergy Clin Immunol 99(1 Pt 1):134-146
    • (1997) J Allergy Clin Immunol , vol.99 , Issue.1 PART 1 , pp. 134-146
    • Lung, C.C.1    Chan, E.K.2    Zuraw, B.L.3
  • 16
    • 0036232406 scopus 로고    scopus 로고
    • Differential regulation of aldosterone synthase and 11betahydroxylase transcription by steroidogenic factor-1
    • Bassett MH, Zhang Y, Clyne C, White PC, Rainey WE (2002) Differential regulation of aldosterone synthase and 11betahydroxylase transcription by steroidogenic factor-1. J Mol Endocrinol 28(2):125-135
    • (2002) J Mol Endocrinol , vol.28 , Issue.2 , pp. 125-135
    • Bassett, M.H.1    Zhang, Y.2    Clyne, C.3    White, P.C.4    Rainey, W.E.5
  • 17
    • 0033524747 scopus 로고    scopus 로고
    • Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing
    • Lee-Kirsch MA, Gaudet F, Cardoso MC, Lindpaintner K (1999) Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ Res 84(2):240-246
    • (1999) Circ Res , vol.84 , Issue.2 , pp. 240-246
    • Ma, L.1    Gaudet, F.2    Cardoso, M.C.3    Lindpaintner, K.4
  • 18
    • 8144221236 scopus 로고    scopus 로고
    • Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    • McNamara DM, Holubkov R, Postava L, Janosko K, MacGowan GA, Mathier M et al (2004) Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. J Am Coll Cardiol 44(10):2019-2026
    • (2004) J Am Coll Cardiol , vol.44 , Issue.10 , pp. 2019-2026
    • McNamara, D.M.1    Holubkov, R.2    Postava, L.3    Janosko, K.4    MacGowan, G.A.5    Mathier, M.6
  • 19
    • 33846106986 scopus 로고    scopus 로고
    • Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure
    • Shin J, Lobmeyer MT, Gong Y, Zineh I, Langaee TY, Yarandi H et al (2007) Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure. Am J Cardiol 99(2):250-255
    • (2007) Am J Cardiol , vol.99 , Issue.2 , pp. 250-255
    • Shin, J.1    Lobmeyer, M.T.2    Gong, Y.3    Zineh, I.4    Langaee, T.Y.5    Yarandi, H.6
  • 20
    • 17144384399 scopus 로고    scopus 로고
    • Genetic contribution to the acute effects of angiotensin II type 1 receptor blockade
    • Spiering W, Kroon AA, Fuss-Lejeune MJ, de Leeuw PW (2005) Genetic contribution to the acute effects of angiotensin II type 1 receptor blockade. J Hypertens 23(4):753-758
    • (2005) J Hypertens , vol.23 , Issue.4 , pp. 753-758
    • Spiering, W.1    Kroon, A.A.2    Fuss-Lejeune, M.J.3    De Leeuw, P.W.4
  • 21
    • 16844374196 scopus 로고    scopus 로고
    • A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension
    • Sookoian S, Castano G, Garcia SI, Viudez P, Gonzalez C, Pirola CJ (2005) A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension. Am J Gastroenterol 100(3):636-642
    • (2005) Am J Gastroenterol , vol.100 , Issue.3 , pp. 636-642
    • Sookoian, S.1    Castano, G.2    Garcia, S.I.3    Viudez, P.4    Gonzalez, C.5    Pirola, C.J.6
  • 22
    • 27944460391 scopus 로고    scopus 로고
    • The effect of angiotensin receptor blockade ARB on the regression of left ventricular hypertrophy in hemodialysis patients: Comparison between patients with D allele and non-D allele ACE gene polymorphism
    • Nakayama M, Nakano H, Tsuboi N, Kurosawa T, Tsuruta Y, Iwasaki Y et al (2005) The effect of angiotensin receptor blockade ARB on the regression of left ventricular hypertrophy in hemodialysis patients: comparison between patients with D allele and non-D allele ACE gene polymorphism. Clin Nephrol 64(5):358-363
    • (2005) Clin Nephrol , vol.64 , Issue.5 , pp. 358-363
    • Nakayama, M.1    Nakano, H.2    Tsuboi, N.3    Kurosawa, T.4    Tsuruta, Y.5    Iwasaki, Y.6
  • 23
    • 0037360987 scopus 로고    scopus 로고
    • B2 bradykinin receptor (B2BKR) polymorphism and change in left ventricular mass in response to antihypertensive treatment: Results from the Swedish irbesartan left ventricular hypertrophy investigation versus atenolol (SILVHIA) trial
    • Hallberg P, Lind L, Michaelsson K, Karlsson J, Kurland L, Kahan T et al (2003) B2 bradykinin receptor (B2BKR) polymorphism and change in left ventricular mass in response to antihypertensive treatment: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial. J Hypertens 21(3):621-624
    • (2003) J Hypertens , vol.21 , Issue.3 , pp. 621-624
    • Hallberg, P.1    Lind, L.2    Michaelsson, K.3    Karlsson, J.4    Kurland, L.5    Kahan, T.6
  • 24
    • 33144478117 scopus 로고    scopus 로고
    • Comprehensive heart failure practice guideline
    • Heart Failure Society of A. HFSA 2006
    • Heart Failure Society Of A. HFSA 2006 (2006) Comprehensive Heart Failure Practice Guideline. J Card Fail 12(1):e1-e2
    • (2006) J Card Fail , vol.12 , Issue.1
  • 25
    • 0035369667 scopus 로고    scopus 로고
    • Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD genotype
    • Cicoira M, Zanolla L, Rossi A, Golia G, Franceschini L, Cabrini G et al (2001) Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD genotype. J Am Coll Cardiol 37(7):1808-1812
    • (2001) J Am Coll Cardiol , vol.37 , Issue.7 , pp. 1808-1812
    • Cicoira, M.1    Zanolla, L.2    Rossi, A.3    Golia, G.4    Franceschini, L.5    Cabrini, G.6
  • 26
    • 2342563834 scopus 로고    scopus 로고
    • Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure
    • Cicoira M, Rossi A, Bonapace S, Zanolla L, Perrot A, Francis DP et al (2004) Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure. Am J Med 116(10):657-661
    • (2004) Am J Med , vol.116 , Issue.10 , pp. 657-661
    • Cicoira, M.1    Rossi, A.2    Bonapace, S.3    Zanolla, L.4    Perrot, A.5    Francis, D.P.6
  • 27
    • 0030865823 scopus 로고    scopus 로고
    • Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype
    • Ohmichi N, Iwai N, Uchida Y, Shichiri G, Nakamura Y, Kinoshita M (1997) Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype. Am J Hypertens 10(8):951-955
    • (1997) Am J Hypertens , vol.10 , Issue.8 , pp. 951-955
    • Ohmichi, N.1    Iwai, N.2    Uchida, Y.3    Shichiri, G.4    Nakamura, Y.5    Kinoshita, M.6
  • 28
    • 0033837696 scopus 로고    scopus 로고
    • Predicting response to chronic antihypertensive treatment with fosinopril: The role of angiotensin-converting enzyme gene polymorphism
    • Stavroulakis GA, Makris TK, Krespi PG, Hatzizacharias AN, Gialeraki AE, Anastasiadis G et al (2000) Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism. Cardiovasc Drugs Ther 14(4):427-432
    • (2000) Cardiovasc Drugs Ther , vol.14 , Issue.4 , pp. 427-432
    • Stavroulakis, G.A.1    Makris, T.K.2    Krespi, P.G.3    Hatzizacharias, A.N.4    Gialeraki, A.E.5    Anastasiadis, G.6
  • 29
    • 0032542030 scopus 로고    scopus 로고
    • ACE (I/D) genotype as a predictor of the magnitude and duration of the response to an ACE inhibitor drug (enalaprilat) in humans
    • Ueda S, Meredith PA, Morton JJ, Connell JM, Elliott HL (1998) ACE (I/D) genotype as a predictor of the magnitude and duration of the response to an ACE inhibitor drug (enalaprilat) in humans. Circulation 98(20):2148-2153
    • (1998) Circulation , vol.98 , Issue.20 , pp. 2148-2153
    • Ueda, S.1    Meredith, P.A.2    Morton, J.J.3    Connell, J.M.4    Elliott, H.L.5
  • 30
    • 21544440123 scopus 로고    scopus 로고
    • Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: The genetics of hypertension-associated treatment (GenHAT) study
    • Arnett DK, Davis BR, Ford CE, Boerwinkle E, Leiendecker-Foster C, Miller MB et al (2005) Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study. Circulation 111(25):3374-3383
    • (2005) Circulation , vol.111 , Issue.25 , pp. 3374-3383
    • Arnett, D.K.1    Davis, B.R.2    Ford, C.E.3    Boerwinkle, E.4    Leiendecker-Foster, C.5    Miller, M.B.6
  • 31
    • 10744222959 scopus 로고    scopus 로고
    • The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition
    • Harrap SB, Tzourio C, Cambien F, Poirier O, Raoux S, Chalmers J et al (2003) The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition. Hypertension 42(3):297-303
    • (2003) Hypertension , vol.42 , Issue.3 , pp. 297-303
    • Harrap, S.B.1    Tzourio, C.2    Cambien, F.3    Poirier, O.4    Raoux, S.5    Chalmers, J.6
  • 32
    • 34447547666 scopus 로고    scopus 로고
    • Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women
    • Fan X, Wang Y, Sun K, Zhang W, Yang X, Wang S et al (2007) Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. Clin Pharmacol Ther 82(2):187-196
    • (2007) Clin Pharmacol Ther , vol.82 , Issue.2 , pp. 187-196
    • Fan, X.1    Wang, Y.2    Sun, K.3    Zhang, W.4    Yang, X.5    Wang, S.6
  • 33
    • 33847153057 scopus 로고    scopus 로고
    • Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitor
    • Su X, Lee L, Li X, Lv J, Hu Y, Zhan S et al (2007) Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitor. Circulation 115(6):725-732
    • (2007) Circulation , vol.115 , Issue.6 , pp. 725-732
    • Su, X.1    Lee, L.2    Li, X.3    Lv, J.4    Hu, Y.5    Zhan, S.6
  • 34
    • 33744816503 scopus 로고    scopus 로고
    • Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors
    • Yu HM, Lin SG, Liu GZ, Zhang YQ, Ma WJ, Deng CY (2006) Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors. Clin Pharmacol Ther 79(6):581-589
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.6 , pp. 581-589
    • Yu, H.M.1    Lin, S.G.2    Liu, G.Z.3    Zhang, Y.Q.4    Ma, W.J.5    Deng, C.Y.6
  • 35
    • 0036381531 scopus 로고    scopus 로고
    • Categorization of humans in biomedical research: Genes, race and disease
    • comment: 2007
    • Risch N, Burchard E, Ziv E, Tang H (2002) Categorization of humans in biomedical research: genes, race and disease. Genome Biol 3(7):comment 2007
    • (2002) Genome Biol , vol.3 , Issue.7
    • Risch, N.1    Burchard, E.2    Ziv, E.3    Tang, H.4
  • 36
    • 0346730904 scopus 로고    scopus 로고
    • Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON)
    • Cohn JN, Pfeffer MA, Rouleau J, Sharpe N, Swedberg K, Straub M et al (2003) Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON). Eur J Heart Fail 5(5):659-667
    • (2003) Eur J Heart Fail , vol.5 , Issue.5 , pp. 659-667
    • Cohn, J.N.1    Ma, P.2    Rouleau, J.3    Sharpe, N.4    Swedberg, K.5    Straub, M.6
  • 37
    • 0035957036 scopus 로고    scopus 로고
    • Results of targeted anti-tumor necrosis factor therapy with etanercept (ENBREL) in patients with advanced heart failure
    • Bozkurt B, Torre-Amione G, Warren MS, Whitmore J, Soran OZ, Feldman AM et al (2001) Results of targeted anti-tumor necrosis factor therapy with etanercept (ENBREL) in patients with advanced heart failure. Circulation 103(8):1044-1047
    • (2001) Circulation , vol.103 , Issue.8 , pp. 1044-1047
    • Bozkurt, B.1    Torre-Amione, G.2    Warren, M.S.3    Whitmore, J.4    Soran, O.Z.5    Feldman, A.M.6
  • 38
    • 11144355788 scopus 로고    scopus 로고
    • Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: A randomized controlled trial
    • Gheorghiade M, Gattis WA, O'Connor CM, Adams KF Jr, Elkayam U, Barbagelata A et al (2004) Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. JAMA 291(16):1963-1971
    • (2004) JAMA , vol.291 , Issue.16 , pp. 1963-1971
    • Gheorghiade, M.1    Gattis, W.A.2    O'connor, C.M.3    Adams Jr., K.F.4    Elkayam, U.5    Barbagelata, A.6
  • 39
    • 33947719178 scopus 로고    scopus 로고
    • Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: The EVEREST clinical status trials
    • Gheorghiade M, Konstam MA, Burnett JC Jr, Grinfeld L, Maggioni AP, Swedberg K et al (2007) Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials. JAMA 297(12):1332-1343
    • (2007) JAMA , vol.297 , Issue.12 , pp. 1332-1343
    • Gheorghiade, M.1    Ma, K.2    Burnett Jr., J.C.3    Grinfeld, L.4    Maggioni, A.P.5    Swedberg, K.6
  • 40
    • 33947606366 scopus 로고    scopus 로고
    • Drug discovery for heart failure: A new era or the end of the pipeline?
    • Kaye DM, Krum H (2007) Drug discovery for heart failure: a new era or the end of the pipeline? Nat Rev Drug Discov 6(2):127-139
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.2 , pp. 127-139
    • Kaye, D.M.1    Krum, H.2
  • 41
    • 4344684441 scopus 로고    scopus 로고
    • Pharmacogenetics and drug development: The path to safer and more effective drugs
    • Roses AD (2004) Pharmacogenetics and drug development: the path to safer and more effective drugs. Nat Rev Genet 5(9):645-656
    • (2004) Nat Rev Genet , vol.5 , Issue.9 , pp. 645-656
    • Roses, A.D.1
  • 42
    • 0023266532 scopus 로고
    • Effects of enalapril on mortality in severe congestive heart failure. Results of the cooperative north scandinavian enalapril survival study (CONSENSUS)
    • The CONSENSUS Trial Study Group
    • Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS) (1987) The CONSENSUS Trial Study Group. N Engl J Med 316(23):1429-1435
    • (1987) N Engl J Med , vol.316 , Issue.23 , pp. 1429-1435


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.