Androgen receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate cancer cells

Cancer Research

Volumn 70, Issue 11, 2010, Pages 4560-4568

  Mehraein Ghomi, Farideh ^a   Basu, Hirak S ^a   Church, Dawn R ^a   Hoffmann, F Michael ^a,b   Wilding, George ^a,c  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; POLYAMINE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR JUND;

AMINO ACID SEQUENCE; ARTICLE; CELL STRAIN LNCAP; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACETYLTRANSFERASES; ANDROGENS; BASE SEQUENCE; CELL LINE, TUMOR; CELL NUCLEUS; GENE EXPRESSION; HUMANS; IMMUNOPRECIPITATION; MALE; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-JUN; REACTIVE OXYGEN SPECIES; RECEPTORS, ANDROGEN;

EID: 77953147739     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3596     Document Type: Article

References (36)

1. Karihtala P, Soini Y. Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies. Acta Pathol Microbiol Immunol Scand 2007;115:81-103.
2. Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 2003;112: 481-490
3. Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 2004;44:239-267
4. Bokov A, Chaudhuri A, Richardson A. The role of oxidative damage and stress in aging. Mech Ageing Dev 2004;125:811-826
5. Cerutti PA. Prooxidant states and tumor promotion. Science 1985; 227:375-381
6. Dargel R. Lipid peroxidation - a common pathogenic mechanism? Exp Toxic Pathol 1992;44:169-181
7. Oberley TD, Oberley LW. Oxygen radicals and cancer. In: Yu BP, editor. Free radicals in aging. CRC Press: Ann Arbor; 1993, p. 247-267
8. Nelson WG, De Marzo AM, DeWeese TL, Issacs WB. The role of inflammation in the pathogenesis of prostate cancer. J Urol 2004; 172:S6-12; discussion S11-12.
9. Bostwick DG, Alexander EE, Singh R, et al. Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer. Cancer 2000;89:123-134
10. Schulze-Osthoff K, Bauer M, Vogt M, Wesselborg S, Baeuerle PA. Reactive oxygen species as primary and second messengers in the activation of transcription factors. In: Forman HJ, Cadenas E, editors. Oxidative stress and signal transduction. New York: Chapman and Hall; 1997, p. 239-259.
11. Oberley TD, Zhong W, Szweda LI, Oberley LW. Localization of antioxidant enzymes and oxidative damage products in normal and malignant prostate epithelium. Prostate 2000;44:144-155
12. Tam NN, Nyska A, Maronpot RR, et al. Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesion in TRAMP mice by dietary antioxidants. Prostate 2006;66:57-69.
13. Sun XY, Donald SP, Phang JM. Testosterone and prostate specific antigen stimulate generation of reactive oxygen species in prostate cancer cells. Carcinogenesis 2001;22:1775-1780 (Pubitemid 33064841)
14. Feig DI, Reid TM, Loeb LA. Reactive oxygen species in tumorigenesis. Cancer Res 1994;54:1890-4s.
15. Hatziapostolou M, Polytarchou C, Katsoris P, Courty J, Papadimitriou E. Heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells. J Biol Chem 2006;281:32217-32226
16. Wilding G. Endocrine control of prostate cancer. Cancer Surv 1995; 23:43-62.
17. Ripple MO, Henry WF, Rago RP, Wilding G. Prooxidant-antioxidant shift induced by androgen treatment of human prostate carcinoma cells. J Natl Cancer Inst 1997;89:40-48 (Pubitemid 26428076)
18. Ripple MO, Hagopian K, Oberley TD, Schatten H, Weindruch R. Androgen-induced oxidative stress in human LNCaP prostate cancer cells is associated with multiple mitochondrial modifications. Antiox Redox Signal 1999;1:71-81. (Pubitemid 129619764)
19. Church DR, Lee E, Thompson TA, et al. Induction of AP-1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells. Prostate 2005;63:155-168
20. Mehraein-Gomi F, Lee E, Church DR, Thompson TA, Basu HS, Wilding G. JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. Prostate 2008;68:924-934
21. Basu HS, Thompson TA, Church DR, et al. A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res 2009;69:7689-7695
22. Thompson TA, Wilding G. Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol in human prostate carcinoma cells. Mol Cancer Ther 2003;2:797-803.
23. Gerald D, Berra E, Frapart YM, et al. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 2004;118:781-794
24. Tsuji Y. JunD activates transcription of the human ferretin H gene through an antioxidant response element during oxidative stress. Oncogene 2005;24:7567-7578
25. Zhou H, Gao J, Lu ZY, Lu L, Dai W, Xu M. Role of c-Fos/JunD in protecting stress-induced cell death. Cell Prolif 2007;40:431-444
26. Hock TD, Liby K, Wright MM, et al. JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. J Biol Chem 2007;282:6875-6886
27. http://www.medpagetoday.com/HematologyOncology/ProstateCancer/4465.
28. Veeramani S, Yuan TC, Lin FF, Lin MF. Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells. Oncogene 2008;27:5057-5068
29. Sharifi N, Hurt EM, Thomas SB, Farrar WL. Effects of manganese superoxide dismutase silencing on androgen receptor function and gene regulation: implications for castration-resistant prostate cancer. Clin Cancer Res 2008;14:6073-6080
30. Remy I, Michnick SW. A highly sensitive protein-protein interaction assay based on Gaussia luciferase. Nat Methods 2006;3:977-979
31. Cai C, Hsieh CL, Shemshedini L. c-Jun has multiple enhancing activities in the novel cross talk between the androgen and Ets variant gene 1 in prostate cancer. Mol Cancer Res 2007;5:725-735
32. Gingras AC, Gstaiger M, Raught B, Aebersold R. Analysis of protein complexes using mass spectrometry. Nat Rev Mol Cell Biol 2007; 8:645-654
33. Babbar N, Hacker A, Huang Y, Casero RA, Jr. Tumor necrosis factor α induces spermidine/spermine N1-acetyltransferase through nuclear factor κB in non-small cell lung cancer cells. J Biol Chem 2006;281:24182-24192
34. Ignatenko NA, Babbar N, Mehta D, Casero RA, Jr., Gerner EW. Suppression of polyamine catabolism by activated ki-ras in human colon cancer cells. Mol Carcinog 2004;39:91-102.
35. Tomitori H, Nenoi M, Mita K, Daino K, Igrashi K, Ichimura S. Functional characterization of the human spermidine/spermine N(1)-acetyltransferase gene promoter. Biochim Biophys Acta 2002; 1579:180-184
36. Angel P, Karin M. The role of Jun, Fos, and the AP-1 complex in cell proliferation and transformation. Biochim Biophys Acta 1991; 1072:129-157