Self inhibition of phagocytosis: The affinity of 'marker of self' CD47 for SIRPα dictates potency of inhibition but only at low expression levels

Blood Cells, Molecules, and Diseases

Volumn 45, Issue 1, 2010, Pages 67-74

  Tsai, Richard K ^a   Rodriguez, Pia L ^a   Discher, Dennis E ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CD47; Circulation; Macrophages; Phagocytosis; Polymorphisms; Red blood cells; SIRP; Stem cells

Indexed keywords

CD47 ANTIGEN; IMMUNOGLOBULIN; REGULATOR PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

ANIMALS; ANTIGENS, CD47; ANTIGENS, DIFFERENTIATION; CELL LINE; GENE EXPRESSION; HUMANS; MACROPHAGES; MICE; PHAGOCYTOSIS; POLYMORPHISM, GENETIC; RECEPTORS, IMMUNOLOGIC;

EID: 77953145255     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2010.02.016     Document Type: Article

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