Expression of muscle segment homeobox genes in the developing myocardium

Anatomical Record

Volumn 293, Issue 6, 2010, Pages 998-1001

  Boogerd, Cornelis J J ^a   Moorman, Antoon F M ^a   Barnett, Phil ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Cardiac conduction system; Heart development; Msx1; Msx2; Muscle segment homeobox genes

Indexed keywords

ANIMAL TISSUE; ARTICLE; GENE; GENE EXPRESSION; HEART DEVELOPMENT; HEART MUSCLE; MOUSE; MUSCLE SEGMENT HOMEOBOX 1 GENE; MUSCLE SEGMENT HOMEOBOX 2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; BODY PATTERNING; ENDOCARDIAL CUSHIONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HEART; HEART CONDUCTION SYSTEM; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MSX1 TRANSCRIPTION FACTOR; MYOCARDIUM; ORGANOGENESIS;

EID: 77953140418     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.21112     Document Type: Article

References (26)

1. Abdelwahid E, Rice D, Pelliniemi LJ, Jokinen E. 2001. Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart. Cell Tissue Res 305:67-78. (Pubitemid 32681869)
2. Bei M, Maas R. 1998. FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development. Development 125:4325-4333. (Pubitemid 28528939)
3. Boogerd KJ, Wong LYE, Christoffels VM, Klarenbeek M, Ruijter JM, Moorman AFM, Barnett P. 2008. Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of connexin 43. Cardiovasc Res 78:485-493.
4. Chan-Thomas PS, Thompson RP, Robert B, Yacoub MH, Barton PJR. 1993. Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick. Dev Dyn 197:203-216.
5. Chen YH, Ishii M, Sucov HM, Maxson RE, Jr. 2008. Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol 8:75.
6. Chen YH, Ishii M, Sun J, Sucov HM, Maxson RE, Jr. 2007. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308:421-437.
7. Christoffels VM, Habets PEMH, Franco D, Campione M, de Jong F, Lamers WH, Bao ZZ, Palmer S, Biben C, Harvey RP, Moorman AFM. 2000. Chamber formation and morphogenesis in the developing mammalian heart. Dev Biol 223:266-278.
8. Christoffels VM, Hoogaars WMH, Tessari A, Clout DEW, Moorman AFM, Campione M. 2004. T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev Dyn 229:763-770.
9. Habets PEMH, Moorman AFM, Clout DEW, van Roon MA, Lingbeek M, Lohuizen M, Campione M, Christoffels VM. 2002. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev 16:1234-1246.
10. Hill RE, Jones PF, Rees AR, Sime CM, Justice MJ, Copeland NG, Jenkins NA, Graham E, Davidson DR. 1989. A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1. Genes Dev 3:26-37.
11. Hoogaars WMH, Barnett P, Moorman AFM, Christoffels VM. 2007. T-box factors determine cardiac design. Cell Mol Life Sci 64:646-660.
12. Houzelstein D, Cohen A, Buckingham ME, Robert B. 1997. Insertional mutation of the mouse Msx1 homeobox gene by an nlacZ reporter gene. Mech Dev 65:123-133.
13. Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE, Jr. 2005. Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development 132:4937-4950.
14. Kwang SJ, Brugger SM, Lazik A, Merrill AE, Wu LY, Liu YH, Ishii M, Sangiorgi FO, Rauchman M, Sucov HM, Maas RL, Maxson RE, Jr. 2002. Msx2 is an immediate downstream effector of Pax3 in the development of themurine cardiac neural crest. Development 129:527-538. (Pubitemid 34863817)
15. Lallemand Y, Nicola MA, Ramos C, Bach A, Cloment CS, Robert B. 2005. Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development. Development 132:3003-3014. (Pubitemid 41086735)
16. Ma L, Lu MF, Schwartz RJ, Martin JF. 2005. Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132:5601-5611. (Pubitemid 43125885)
17. MacKenzie A, Ferguson MW, Sharpe PT. 1992. Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape. Development 115:403-420.
18. MacKenzie A, Leeming GL, Jowett AK, Ferguson MW, Sharpe PT. 1991. The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro. Development 111:269-285.
19. Monaghan AP, Davidson DR, Sime C, Graham E, Baldock R, Bhattacharya SS, Hill RE. 1991. The Msh-like homeobox genes define domains in the developing vertebrate eye. Development 112:1053-1061. (Pubitemid 21900306)
20. Moorman AFM, Houweling AC, de Boer PAJ, Christoffels VM. 2001. Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol. J Histochem Cytochem 49:1-8.
21. Robert B, Sassoon D, Jacq B, Gehring W, Buckingham M. 1989. Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J 8:91-100. (Pubitemid 19273950)
22. Satokata I, Ma L, Ohshima H, Bei M, Woo I, Nishizawa K, Maeda T, Takano Y, Uchiyama M, Heaney S, Peters H, Tang Z, Maxson R, Maas R. 2000. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet 24:391-395. (Pubitemid 30187439)
23. Satokata I, Maas R. 1994. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet 6:348-356. (Pubitemid 24190017)
24. Singh R, Horsthuis T, Farin HF, Grieskamp T, Norden J, Petry M, Wakker V, Moorman AF, Christoffels VM, Kispert A. 2009. Tbx20 interacts with smads to confine Tbx2 expression to the atrioventricular canal. Circ Res 105:442-452.
25. Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S. 1999. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream ofmultiple genes essential for heart development. Development 126:1269-1280. (Pubitemid 29182122)
26. Thomas PS, Kasahara H, Edmonson AM, Izumo S, Yacoub MH, Barton PJR, Gourdie RG. 2001. Elevated expression of Nkx-2.5 in developing myocardial conduction cells. Anat Rec 263:307-313. (Pubitemid 32606317)