New aryldithiolethione derivatives as potent histone deacetylase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4187-4194

  Tazzari, Valerio ^a   Cappelletti, Graziella ^b   Casagrande, Manolo ^b   Perrino, Elena ^a   Renzi, Luigi ^b   Del Soldato, Piero ^a   Sparatore, Anna ^a,b  

^a Progress Srl   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Anticancer agents; Dithiolethione derivatives; Histone deacetylase inhibitor

Indexed keywords

1,3 DITHIOLE 2 THIOXO 4 CARBOXYLIC ACID; 4 (3 THIOXO 3H 1,2 DITHIOL 4 YL)BENZOIC ACID; 4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL 4 PHENYLBUTANOATE; 4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL 8 (HYDROXYAMINO) 8 OXOOCTANOATE; 4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL 8 OXO 8 (PHENYLAMINO)OCTANOATE; 5 (4 HYDROXYPHENYL) 3H 1,2 DITHIOLE 3 THIONE; [2 METHOXY 4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENOXY]ACETIC ACID; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE INHIBITOR; N HYDROXY 5 [4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENOXY]PENTANAMIDE; N HYDROXY 7 [4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENOXY]HEPTANAMIDE; N PHENYL 5 [4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENOXY]PENTANAMIDE; N PHENYL 7 [4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENOXY]HEPTANAMIDE; N(2 AMINOPHENYL) 7 [4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENOXY]HEPTANAMIDE; N1 PHENYL N8 (2 THIOXO 1,3 DITHIOLE 4 CARBONYLOXY)OCTANEDIAMIDE; N1 PHENYL N8 [4 (3 THIOXO 3H 1,2 DITHIOL 4 YL)BENZOYLOXY]OCTANDEIAMIDE; UNCLASSIFIED DRUG; VORINOSTAT; HISTONE DEACETYLASE; HYDROXAMIC ACID; N-HYDROXY-5-(4-(3-THIOXO-3H-1,2-DITHIOL-5-YL)PHENOXY)PENTANAMIDE; N-HYDROXY-7-(4-(3-THIOXO-3H-1,2-DITHIOL-5-YL)PHENOXY)HEPTANAMIDE; THIOPHENE DERIVATIVE; VALPROIC ACID;

ACETYLATION; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG ADENOCARCINOMA; CHEMISTRY; DRUG SCREENING; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; THIOPHENES; VALPROIC ACID;

EID: 77953140001     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.011     Document Type: Article

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