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Volumn 18, Issue 10, 2010, Pages 3506-3517
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Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity
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Author keywords
Molecular modeling; PDE4 inhibitors; Pyrazoles; Pyrazolo 3,4 d pyridazinones; Structure activity relationship
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Indexed keywords
2 (2 CHLOROPHENYL) 6 ETHYL 4 (HYDROXYMETHYL) 3 METHYL 2H PYRAZOLO[3,4 D]PYRIDAZIN 7(6H) ONE;
2 (2 CHLOROPHENYL) 6 ETHYL 4 (METHOXYMETHYL) 3 METHYL 2H PYRAZOLO[3,4 D]PYRIDAZIN 7(6H) ONE;
2 (2 CHLOROPHENYL) 6 ETHYL 6,7 DIHYDRO 3 METHYL 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBONITRILE;
2 (2 CHLOROPHENYL) 6 ETHYL 6,7 DIHYDRO 3 METHYL 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXAMIDE;
2 (2,6 DICHLOROPHENYL) 6 ETHYL 6,7 DIHYDRO 3 METHYL 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBONITRILE;
6 ETHYL 3 METHYL 4 (5 METHYL 1,3,4 OXADIAZOL 2 YL) 2 (3 NITROPHENYL) 2H PYRAZOLO[3,4 D]PYRIDAZIN 7(6H)ONE;
6 ETHYL 6,7 DIHYDRO 3 METHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLIC ACID;
6 ETHYL 6,7 DIHYDRO N,3 DIMETHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXAMIDE;
6 ETHYL 6,7 DIHYDRO N,N,3 TRIMETHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXAMIDE;
ALKYL GROUP;
ETHYL 2 (3 (METHOXYCARBONYL)BENZYL) 6 ETHYL 6,7 DIHYDRO 3 METHYL 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
ETHYL 2 (3 METHYL 2 (3 NITROPHENYL) 7 OXO 4 PHENYL 2H PYRAZOLO[3,4 D] 6(7H) YL)ACETATE;
ETHYL 2 (4 CYANOBENZYL) 6 ETHYL 6,7 DIHYDRO 3 METHYL 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
ETHYL 2 (4 NITROBENZYL) 6 ETHYL 6,7 DIHYDRO 3 METHYL 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
ETHYL 2(2 CHLOROPHENYL) 6 ETHYL 6,7 DIHYDRO 3 METHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
ETHYL 3 (3 METHYL 2 (3 NITROPHENYL) 7 OXO 4 PHENYL 2H PYRAZOLO[3,4 D] 6(7H) YL)PROPANOATE;
ETHYL 6 ETHYL 6,7 DIHYDRO 3 METHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
ETHYL 6 ETHYL 6,7 DIHYDRO 3 METHYL 7 OXO 2 PHENYL 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
ETHYL 6 ETHYL 6,7 DIHYDRO 3 METHYL 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
ISOPROPYL 6 ETHYL 6,7 DIHYDRO 3 METHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
METHYL 6 ETHYL 6,7 DIHYDRO 3 METHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
N,2,6 DICHLORO(4 PYRIDIN) 6 ETHYL 6,7 DIHYDRO 2 PHENYL 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXAMIDE;
N,6 DIETHYL 6,7 DIHYDRO N,3 DIMETHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXAMIDE;
PHOSPHODIESTERASE IV;
PHOSPHODIESTERASE IV INHIBITOR;
PROPYL 6 ETHYL 6,7 DIHYDRO 3 METHYL 2 (3 NITROPHENYL) 7 OXO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4 CARBOXYLATE;
PYRAZOLE DERIVATIVE;
PYRIDAZINONE DERIVATIVE;
TUMOR NECROSIS FACTOR ALPHA;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ARTICLE;
CYTOKINE RELEASE;
DRUG PROTEIN BINDING;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
HUMAN;
IC 50;
IN VITRO STUDY;
PERIPHERAL BLOOD MONONUCLEAR CELL;
STRUCTURE ACTIVITY RELATION;
CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4;
HUMANS;
INHIBITORY CONCENTRATION 50;
MALE;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
PHOSPHODIESTERASE INHIBITORS;
PYRAZOLES;
PYRIDAZINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
SUBSTRATE SPECIFICITY;
TUMOR NECROSIS FACTOR-ALPHA;
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EID: 77953139426
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2010.03.066 Document Type: Article |
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Times cited : (21)
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References (39)
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