Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 10, 2010, Pages 3481-3493

  Leiris, Simon J ^a   Khdour, Omar M ^a   Segerman, Zachary J ^a   Tsosie, Krystal S ^a   Chapuis, Jean Charles ^a   Hecht, Sidney M ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Mitochondrial complex I; NADH oxidase; NADH ubiquinone oxidoreductase; Verticipyrone analogues

Indexed keywords

2 (2 HYDROXY 7 PHENOXYHEPTYL) 6 METHOXY 3,5 DIMETHYL 4H PYRAN 4 ONE; 2 (2 HYDROXY 8 PHENYLOCTYL) 6 METHOXY 3,5 DIMETHYL 4H PYRAN 4 ONE; 2 (2 HYDROXYHEXYL) 6 METHOXY 3,5 DIMETHYL 4H PYRAN 4 ONE; 2 (2 HYDROXYUNDECYL) 6 METHOXY 3,5 DIMETHYL 4H PYRAN 4 ONE; 2 [2 HYDROXY 7 (4 PHENYL)PHENOXYHEPTYL] 6 METHOXY 3,5 DIMETHYL 4H PYRAN 4 ONE; 2 [3 HYDROXY 3 METHYLUNDECYL] 3,5,6 TRIMETHYL 4H PYRAN 4 ONE; 2 [3 HYDROXY 3 METHYLUNDECYL] 6 METHOXY 3,5 DIMETHYL 4H PYRAN 4 ONE; 6 [3 HYDROXY 3 METHYLUNDECYL] 3,5 DIMETHYL 4 HYDROXYPYRAN 2 ONE; 6 [3 HYDROXY 3 METHYLUNDECYL] 3,5 DIMETHYL 4 HYDROXYPYRIDIN 2 ONE; ANTIMYCIN A1; OXIDOREDUCTASE INHIBITOR; PYRONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; UNCLASSIFIED DRUG; VERTICIPYRONE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LEWIS CARCINOMA; LUNG CARCINOMA; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN;

ALKENES; MITOCHONDRIA; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA; VERTICILLIUM SP.;

EID: 77953138590     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.070     Document Type: Article

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