The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis

Journal of Organic Chemistry

Volumn 72, Issue 14, 2007, Pages 5085-5090

  Surup, Frank ^a   Wagner, Oliver ^a   Von Frieling, Jan ^a   Schleicher, Michael ^b   Oess, Stefanie ^b   Müller, Peter ^c   Grond, Stephanie ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IROMYCINS; MEDICAL THERAPY; NITRIC OXIDE SYNTHASES (NOS); STREPTOMYCES SP.;

BACTERIA; BIOSYNTHESIS; DETOXIFICATION; ENZYME INHIBITION; NITRIC OXIDE;

METABOLITES;

ENDOTHELIAL NITRIC OXIDE SYNTHASE; IROMYCIN; IROMYCIN A; IROMYCIN B; IROMYCIN C; IROMYCIN D; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; ENZYME INHIBITION; NITROGEN NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STREPTOMYCES;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE; PYRIDINES; STREPTOMYCES;

EID: 34447326165     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0703303     Document Type: Article

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