Brain nonoxidative carbohydrate consumption is not explained by export of an unknown carbon source: Evaluation of the arterial and jugular venous metabolome

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 6, 2010, Pages 1240-1246

  Rasmussen, Peter ^a,b,c   Nyberg, Nils ^d   Jaroszewski, Jerzy W ^d   Krogh Madsen, Rikke ^a,b   Secher, Niels H ^a,b   Quistorff, Bjørn ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Carbohydrate; Lactate; Metabolism; NMR

Indexed keywords

CARBOHYDRATE; CARBON; GLUCOSE; LACTIC ACID;

ADULT; ARTICLE; BRACHIAL ARTERY; CARBOHYDRATE INTAKE; CARBOHYDRATE METABOLISM; HUMAN; HUMAN EXPERIMENT; JUGULAR VEIN; MALE; METABOLOME; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ADULT; BLOOD GLUCOSE; BRAIN; CARBON; EXERCISE; HUMANS; JUGULAR VEINS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; OXIDATION-REDUCTION;

EID: 77953134828     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.25     Document Type: Article

References (28)

1. Ball KK, Cruz NF, Mrak RE, Dienel GA (2010) Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes. J Cereb Blood Flow Metab 30:162-176
2. 2 tension. Neuroradiology 10:257-262
3. Dalsgaard MK (2006) Fuelling cerebral activity in exercising man. J Cereb Blood Flow Metab 26:731-750
4. Dalsgaard MK, Ide K, Cai Y, Quistorff B, Secher NH (2002) The intent to exercise influences the cerebral O(2)/carbohydrate uptake ratio in humans. J Physiol 540: 681-689
5. Dalsgaard MK, Quistorff B, Danielsen ER, Selmer C, Vogelsang T, Secher NH (2004) A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain. J Physiol 554:571-578
6. Fox PT, Raichle ME, Mintun MA, Dence C (1988) Non-oxidative glucose consumption during focal physiologic neural activity. Science 241:462-464
7. Friedman DB, Friberg L, Mitchell JH, Secher NH (1991) Effect of axillary blockade on regional cerebral blood flow during static handgrip. J Appl Physiol 71:651-656
8. Giller CA, Bowman G, Dyer H, Mootz L, Krippner W, Loftus CM, Muizelaar JP (1993) Cerebral arterial diameters during changes in blood-pressure and carbon-dioxide during craniotomy. Neurosurgery 32:737-742
9. Hasselbalch S, Knudsen G, Jakobsen J, Hageman L, Holm S, Paulson OB (1994) Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab 14: 125-131
10. Hellström G, Fischer-Colbrie W, Wahlgren NG, Jögestrand T (1996) Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise. J Appl Physiol 81:413-418
11. Ide K, Horn A, Secher N (1999) Cerebral metabolic response to submaximal exercise. J Appl Physiol 87: 1604-1608
12. Jørgensen LG (1995) Transcranial Doppler ultrasound for cerebral perfusion. Acta Physiol Scand Suppl 625:1-44
13. Kemppainen J, Aalto S, Fujimoto T, Kalliokoski KK, Langsjo J, Oikonen V, Rinne J, Nuutila P, Knuuti J (2005) High intensity exercise decreases global brain glucose uptake in humans. J Physiol 568:323-332
14. Kristeva-Feige R, Fritsch C, Timmer J, Lucking CH (2002) Effects of attention and precision of exerted force on beta range EEG-EMG synchronization during a maintained motor contraction task. Clin Neurophysiol 113: 124-131
15. Madsen PL, Cruz NF, Sokoloff L, Dienel GA (1999) Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. J Cereb Blood Flow Metab 19:393-400
16. Madsen PL, Holm S, Herning M, Lassen NA (1993) Average blood flow and oxygen uptake in the human brain during resting wakefulness: a critical appraisal of the Kety-Schmidt technique. J Cereb Blood Flow Metab 13:646-655
17. 2 uptake in humans. J Appl Physiol 73:420-426
18. Nicholson JK, Buckingham MJ, Sadler PJ (1983) High resolution proton NMR studies of vertebrate blood and plasma. Biochem J 211:605-615
19. Nicholson JK, Wilson ID (1989) High resolution proton magnetic resonance spectroscopy of biological fluids. Prog Nucl Magn Reson Spectrosc 21:449-501
20. 2 supplementation. Am J Physiol Heart Circ Physiol 277:H1045-52
21. Quistorff B, Secher NH, Van Lieshout JJ (2008) Lactate fuels the human brain during exercise. FASEB J 22:3443-3449
22. Rasmussen P, Madsen CA, Nielsen HB, Zaar M, Gjedde A, Secher NH, Quistorff B (2009) Coupling between the blood lactate to pyruvate ratio and MCA Vmean at the onset of exercise in humans. J Appl Physiol 107: 1799-1805
23. Rasmussen P, Plomgaard P, Krogh-Madsen R, Kim YS, van Lieshout JJ, Secher NH, Quistorff B (2006) MCA Vmean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip. J Appl Physiol 101: 1406-1411
24. Rasmussen P, Stie H, Nybo L, Nielsen B (2004) Heat induced fatigue and changes of the EEG is not related to reduced perfusion of the brain during prolonged exercise in humans. J Therm Biol 29:731-737
25. Seifert T, Rasmussen P, Brassard P, Homann PH, Wissen-berg M, Nordby P, Stallknecht B, Secher NH, Nielsen HB (2009) Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males. Am J Physiol Regul Integr Comp Physiol 297:R867-76
26. Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL (2000) MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31:1672-1678
27. van Hall G, Stromstad M, Rasmussen P, Jans O, Zaar M, Gam C, Quistorff B, Secher NH, Nielsen HB (2009) Blood lactate is an important energy source for the human brain. J Cereb Blood Flow Metab 29: 1121-1129
28. Volianitis S, Fabricius-Bjerre A, Overgaard A, Stromstad M, Bjarrum M, Carlsson C, Petersen N, Rasmussen P, Secher NH, Nielsen HB (2008) The cerebral metabolic ratio is not affected by oxygen availability during maximal exercise in humans. J Physiol 586:107-112