Improvement and induction property of radiation-responsive promoter through DNA shuffling of 5′-flanking regions of the human p21 gene

Journal of Bioscience and Bioengineering

Volumn 110, Issue 1, 2010, Pages 118-123

  Kagiya, Go ^a,b   Ogawa, Ryohei ^c   Cook, John A ^b   Choudhuri, Rajani ^b   Hatashita, Masanori ^d   Tanaka, Yoshikazu ^d   DeGraff, Bill G ^b   Mitchell, James B ^b  

^a KITASATO UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF TOYAMA   (Japan)

^d WAKASA WAN ENERGY RESEARCH CENTER   (Japan)

Author keywords

DNA shuffling; p21; p53 responsive element; Radiation; Radiation responsive promoter

Indexed keywords

CELL LINES; CIS-ACTING ELEMENT; DNA FRAGMENT; DNA SHUFFLING; FLANKING REGIONS; IMPROVE-A; NUCLEOTIDE SEQUENCE ANALYSIS; P21; PROMOTER FRAGMENTS;

BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CELL CULTURE; GENE EXPRESSION; GENE THERAPY; GENETIC ENGINEERING; IONIZING RADIATION; RADIATION SHIELDING; RADIOACTIVITY;

DNA;

CIS ACTING ELEMENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR FACTOR Y; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA FLANKING REGION; DNA FRAGMENTATION; DNA SHUFFLING; FEMALE; GAMMA IRRADIATION; GAMMA RADIATION; GENE EXPRESSION; GENE INDUCTION; GENE LIBRARY; HUMAN; HUMAN CELL; IONIZING RADIATION; MALE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RADIATION RESPONSE; SEQUENCE ANALYSIS;

5' FLANKING REGION; BASE SEQUENCE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA, RECOMBINANT; HELA CELLS; HT29 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RADIATION, IONIZING; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTOR AP-1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953122196     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2009.12.013     Document Type: Article

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