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Volumn 70, Issue 9, 2010, Pages 1189-1213

Maraviroc: A review of its use in the management of CCR5-Tropic HIV-1 infection

Author keywords

Adis Drug Evaluations; HIV infections; Maraviroc, general

Indexed keywords

ALANINE AMINOTRANSFERASE; AMYLASE; ASPARTATE AMINOTRANSFERASE; ATAZANAVIR; BILIRUBIN; CHEMOKINE RECEPTOR CCR5; CLARITHROMYCIN; DARUNAVIR; DARUNAVIR PLUS RITONAVIR; EFAVIRENZ; ETRAVIRINE; HYPERICUM PERFORATUM EXTRACT; IMMUNOGLOBULIN E; ITRACONAZOLE; KETOCONAZOLE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; MARAVIROC; RIFAMPICIN; RITONAVIR PLUS SAQUINAVIR; TELITHROMYCIN; TRIACYLGLYCEROL LIPASE;

EID: 77953097279     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11203940-000000000-00000     Document Type: Review
Times cited : (85)

References (64)
  • 2
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society USA panel
    • Aug 6
    • Hammer SM, Eron Jr JJ, Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society USA panel. JAMA 2008 Aug 6; 300 (5): 555-570
    • (2008) JAMA , vol.300 , Issue.5 , pp. 555-570
    • Hammer, S.M.1    Eron Jr., J.J.2    Reiss, P.3
  • 3
    • 77953087014 scopus 로고    scopus 로고
    • European AIDS Clinical Society. Guidelines for the clinical management and treatment of HIV-infected adults in Europe [online] [Accessed 2010 May 23]
    • European AIDS Clinical Society. Guidelines for the clinical management and treatment of HIV-infected adults in Europe [online]. Available from URL: http://www.european aidsclinicalsociety.org/guidelinespdf/1-Treatment-of-HIV- Infected-Adults.pdf [Accessed 2010 May 23]
  • 4
    • 52749083531 scopus 로고    scopus 로고
    • British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008
    • Gazzard BG, Anderson J, Babiker A, et al. British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. HIV Med 2008; 9: 563-608
    • (2008) HIV Med , vol.9 , pp. 563-608
    • Gazzard, B.G.1    Anderson, J.2    Babiker, A.3
  • 5
    • 48049107573 scopus 로고    scopus 로고
    • Potential for new anti-retrovirals to address unmet needs in the management of HIV-1 infection
    • Jun
    • Moyle G, Gatell J, Perno CF, et al. Potential for new anti-retrovirals to address unmet needs in the management of HIV-1 infection. AIDS Patient Care STDS 2008 Jun; 22 (6): 459-471
    • (2008) AIDS Patient Care STDS , vol.22 , Issue.6 , pp. 459-471
    • Moyle, G.1    Gatell, J.2    Perno, C.F.3
  • 6
    • 59749083393 scopus 로고    scopus 로고
    • Novel targets for antiretroviral ther-apy: Clinical progress to date
    • Dau B, Holodniy M. Novel targets for antiretroviral ther-apy: clinical progress to date. Drugs 2009; 69 (1): 31-50
    • (2009) Drugs , vol.69 , Issue.1 , pp. 31-50
    • Dau, B.1    Holodniy, M.2
  • 7
    • 40549088890 scopus 로고    scopus 로고
    • A review of the clinical pharmacology of maraviroc: Introduction
    • Apr
    • Boffito M, Abel S. A review of the clinical pharmacology of maraviroc: introduction. Br J Clin Pharmacol 2008 Apr; 65 Suppl. 1: 1-4
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 1-4
    • Boffito, M.1    Abel, S.2
  • 8
    • 46349097362 scopus 로고    scopus 로고
    • Reviews of anti-infective agents. Maraviroc: The first of a new class of antiretroviral agents
    • Jul 15
    • MacArthur RD, Novak RM. Reviews of anti-infective agents. Maraviroc: the first of a new class of antiretroviral agents. Clin Infect Dis 2008 Jul 15; 47 (2): 236-241
    • (2008) Clin Infect Dis , vol.47 , Issue.2 , pp. 236-241
    • MacArthur, R.D.1    Novak, R.M.2
  • 9
    • 33646755473 scopus 로고    scopus 로고
    • Discovery and development of small-molecule chemokine coreceptor CCR5 antagonists
    • Palani A, Tagat JR. Discovery and development of small-molecule chemokine coreceptor CCR5 antagonists. J Med Chem 2006; 49 (10): 2851-2857
    • (2006) J Med Chem , vol.49 , Issue.10 , pp. 2851-2857
    • Palani, A.1    Tagat, J.R.2
  • 10
    • 35548961311 scopus 로고    scopus 로고
    • Genotypic coreceptor analysis
    • Oct 15
    • Sierra S, Kaiser R, Thielen A, et al. Genotypic coreceptor analysis. Eur J Med Res 2007 Oct 15; 12 (9): 453-462
    • (2007) Eur J Med Res , vol.12 , Issue.9 , pp. 453-462
    • Sierra, S.1    Kaiser, R.2    Thielen, A.3
  • 11
    • 40849098660 scopus 로고    scopus 로고
    • Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists
    • Mar
    • Kondru R, Zhang J, Ji C, et al. Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists. Mol Pharmacol 2008 Mar; 73 (3): 789-800
    • (2008) Mol Pharmacol , vol.73 , Issue.3 , pp. 789-800
    • Kondru, R.1    Zhang, J.2    Ji, C.3
  • 12
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pre-treatment CXCR4-using virus reservoir
    • May
    • Westby M, Lewis M, Whitcomb J, et al. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pre-treatment CXCR4-using virus reservoir. J Virol 2006 May; 80 (10): 4909-4920
    • (2006) J Virol , vol.80 , Issue.10 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3
  • 13
    • 77749268003 scopus 로고    scopus 로고
    • Maraviroc for treatment-naive patients with HIV-1 infection: Is the glass half empty or half full?
    • Mar 15
    • Sax PE. Maraviroc for treatment-naive patients with HIV-1 infection: is the glass half empty or half full? J Infect Dis 2010 Mar 15; 201: 797-799
    • (2010) J Infect Dis , vol.201 , pp. 797-799
    • Sax, P.E.1
  • 14
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
    • Mar
    • Westby M, Smith-Burchnell C, Mori J, et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry. J Virol 2007 Mar; 81 (5): 2359-2371
    • (2007) J Virol , vol.81 , Issue.5 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3
  • 15
    • 77953111933 scopus 로고    scopus 로고
    • Celsentri (maraviroc): Summary of product characteristics
    • European Medicines Agency Jan 11 [online]. Available from URL:, [Accessed 2010 May 23]
    • European Medicines Agency. Celsentri (maraviroc): summary of product characteristics. Updated 2010 Jan 11 [online]. Available from URL: http://www.emea.europa.eu/human docs/PDFs/EPAR/celsentri/emea-combined-h811en. pdf [Accessed 2010 May 23]
    • (2010) Updated
  • 16
    • 77953104148 scopus 로고    scopus 로고
    • Pfizer Inc. Selzentry (maraviroc) US prescribing information. Revised 11/2009 [online]. Available from URL: [Accessed 2010 May 23]
    • Pfizer Inc. Selzentry (maraviroc) US prescribing information. Revised 11/2009 [online]. Available from URL: http://us.gsk.com/products/assets/us- selzentry.pdf [Accessed 2010 May 23]
  • 17
    • 64649102626 scopus 로고    scopus 로고
    • Design and validation of new genotypic tools for easy and reliable estimation of HIV tropism before using CCR5 antagonists
    • May
    • Poveda E, Seclen E, Gonzalez M del M, et al. Design and validation of new genotypic tools for easy and reliable estimation of HIV tropism before using CCR5 antagonists. J Antimicrob Chemother 2009 May; 63 (5): 1006-1010
    • (2009) J Antimicrob Chemother , vol.63 , Issue.5 , pp. 1006-1010
    • Poveda, E.1    Seclen, E.2    Gonzalez Del M, M.3
  • 18
    • 54849146700 scopus 로고    scopus 로고
    • Maraviroc for previously treated patients with R5 HIV-1 infection
    • Oct 2
    • Gulick RM, Lalezari J, Goodrich J, et al. Maraviroc for previously treated patients with R5 HIV-1 infection. N Engl J Med 2008 Oct 2; 359 (14): 1429-1441
    • (2008) N Engl J Med , vol.359 , Issue.14 , pp. 1429-1441
    • Gulick, R.M.1    Lalezari, J.2    Goodrich, J.3
  • 19
    • 77749271329 scopus 로고    scopus 로고
    • Maraviroc versus efavirenz, both in combination with zidovudine- lamivudine, for the treatment of antiretroviral-naive subjects with CCR5-tropic HIV-1 infection
    • Mar 15
    • Cooper DA, Heera J, Goodrich J, et al. Maraviroc versus efavirenz, both in combination with zidovudine-lamivudine, for the treatment of antiretroviral-naive subjects with CCR5-tropic HIV-1 infection. J Infect Dis 2010 Mar 15; 201: 803-813
    • (2010) J Infect Dis , vol.201 , pp. 803-813
    • Cooper, D.A.1    Heera, J.2    Goodrich, J.3
  • 20
    • 77953112610 scopus 로고    scopus 로고
    • The MERIT study of maraviroc in antiretroviral-naive patients with R5 HIV-1: 96-week results [slide presentation TUAB103]
    • Jul Capetown
    • Heera J, Ive M, Botes M. The MERIT study of maraviroc in antiretroviral-naive patients with R5 HIV-1: 96-week results [slide presentation TUAB103]. 5th International AIDS Society Conference on HIV Pathogenesis; 2009 Jul 19-22; Capetown
    • (2009) 5th International AIDS Society Conference on HIV Pathogenesis; , pp. 19-22
    • Heera, J.1    Ive, M.2    Botes, M.3
  • 21
    • 56549123524 scopus 로고    scopus 로고
    • Virological correlates asso-ciated with treatment failure at week 48 in the phase 3 study of maraviroc in treatment-naive patients [abstract no. 40LB]
    • Feb 3-6 Boston (MA) 22.
    • Heera J, Saag M, Ive P, et al. Virological correlates asso-ciated with treatment failure at week 48 in the phase 3 study of maraviroc in treatment-naive patients [abstract no. 40LB]. 15th Conference on Retroviruses and Opportunistic Infections; 2008 Feb 3-6; Boston (MA) 22.
    • (2008) 15th Conference on Retroviruses and Opportunistic Infections;
    • Heera, J.1    Saag, M.2    Ive, P.3
  • 22
    • 35048840600 scopus 로고    scopus 로고
    • Maraviroc
    • discussion 2289-2290
    • Carter NJ, Keating GM. Maraviroc. Drugs 2007; 67 (15): 2277-88; discussion 2289-2290
    • (2007) Drugs , vol.67 , Issue.15 , pp. 2277-88
    • Carter, N.J.1    Keating, G.M.2
  • 23
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UK-427 857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
    • Nov
    • Dorr P, Westby M, Dobbs S, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother 2005 Nov; 49 (11): 4721-4732
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.11 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3
  • 24
    • 54849145400 scopus 로고    scopus 로고
    • Subgroup analyses of maraviroc in previously treated R5 HIV-1 infection
    • Oct 2
    • Fatkenheuer G, Nelson M, Lazzarin A, et al. Subgroup analyses of maraviroc in previously treated R5 HIV-1 infection. N Engl J Med 2008 Oct 2; 359 (14): 1442-1455
    • (2008) N Engl J Med , vol.359 , Issue.14 , pp. 1442-1455
    • Fatkenheuer, G.1    Nelson, M.2    Lazzarin, A.3
  • 25
    • 66949122460 scopus 로고    scopus 로고
    • Drug interactions with new and investigational antiretrovirals
    • Brown KC, Paul S, Kashuba AD. Drug interactions with new and investigational antiretrovirals. Clin Pharmaco-kinet 2009; 48 (4): 211-241
    • (2009) Clin Pharmaco-kinet , vol.48 , Issue.4 , pp. 211-241
    • Brown, K.C.1    Paul, S.2    Kashuba, A.D.3
  • 26
    • 55249097908 scopus 로고    scopus 로고
    • Primary geno-typic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients
    • Oct 18
    • Soulie C, Malet I, Lambert-Niclot S, et al. Primary geno-typic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients. AIDS 2008 Oct 18; 22 (16): 2212-2214
    • (2008) AIDS , vol.22 , Issue.16 , pp. 2212-2214
    • Soulie, C.1    Malet, I.2    Lambert-Niclot, S.3
  • 27
    • 18644369147 scopus 로고    scopus 로고
    • The appealing story of HIV entry inhibitors: From discovery of biological mechanisms to drug development
    • Castagna A, Biswas P, Beretta A, et al. The appealing story of HIV entry inhibitors: from discovery of biological mechanisms to drug development. Drugs 2005; 65 (7): 879-904
    • (2005) Drugs , vol.65 , Issue.7 , pp. 879-904
    • Castagna, A.1    Biswas, P.2    Beretta, A.3
  • 28
    • 55249099476 scopus 로고    scopus 로고
    • Changes in V3 loop sequence associated with failure of maraviroc treatment in patients enrolled in the MOTIVATE 1 and 2 trials [abstract no. 871]
    • Feb Boston (MA)
    • Lewis M, Mori J, Simpson P, et al. Changes in V3 loop sequence associated with failure of maraviroc treatment in patients enrolled in the MOTIVATE 1 and 2 trials [abstract no. 871]. 15th Conference on Retroviruses and Opportunistic Infections; 2008 Feb 3-6; Boston (MA)
    • (2008) 15th Conference on Retroviruses and Opportunistic Infections; , pp. 3-6
    • Lewis, M.1    Mori, J.2    Simpson, P.3
  • 29
    • 40649110404 scopus 로고    scopus 로고
    • Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic HIV-1 in MOTIVATE 1 and MOTIVATE 2 [abstract no. 10]
    • Jun Barbados
    • Mori J, Lewis M, Simpson P, et al. Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic HIV-1 in MOTIVATE 1 and MOTIVATE 2 [abstract no. 10]. XVI International HIV Drug Resistance Workshop; 2007 Jun 12-16; Barbados
    • (2007) XVI International HIV Drug Resistance Workshop; , pp. 12-16
    • Mori, J.1    Lewis, M.2    Simpson, P.3
  • 30
    • 65749090989 scopus 로고    scopus 로고
    • Dual-tropic virus clones from patients enrolled in the MOTIVATE studies may respond differently in vivo to maraviroc based on their V3 loop sequence [abstract no. 50]
    • Mar Budapest
    • Lewis M, Simpson P, Xiting L, et al. Dual-tropic virus clones from patients enrolled in the MOTIVATE studies, may respond differently in vivo to maraviroc based on their V3 loop sequence [abstract no. 50]. Sixth European HIV Drug Resistance Workshop; 2008 Mar 26-28; Budapest
    • (2008) Sixth European HIV Drug Resistance Workshop; , pp. 26-28
    • Lewis, M.1    Simpson, P.2    Xiting, L.3
  • 31
    • 65749098603 scopus 로고    scopus 로고
    • Maraviroc: Perspectives for use in antiretroviral-naive HIV-1-infected patients
    • Jun
    • Vandekeckhove L, Verhofstede C, Vogelaers D. Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients. J Antimicrob Chemother 2009 Jun; 63 (6): 1087-1096
    • (2009) J Antimicrob Chemother , vol.63 , Issue.6 , pp. 1087-1096
    • Vandekeckhove, L.1    Verhofstede, C.2    Vogelaers, D.3
  • 32
    • 77953115471 scopus 로고    scopus 로고
    • Ultradeep pyrosequencing and phenotypic analysis to characterize the V3 genetic diversity among HIV-1 primary isolates and their responses to maraviroc [slide presentation]
    • Mar Stockholm
    • Svicher V, Balestra E, Vandenbroucke I, et al. Ultradeep pyrosequencing and phenotypic analysis to characterize the V3 genetic diversity among HIV-1 primary isolates and their responses to maraviroc [slide presentation]. 7th European HIV Drug Resistance Workshop; 2009 Mar 25-27; Stockholm
    • (2009) 7th European HIV Drug Resistance Workshop; , pp. 25-27
    • Svicher, V.1    Balestra, E.2    Vandenbroucke, I.3
  • 33
    • 77953095023 scopus 로고    scopus 로고
    • Low detection of non-CCR5 using strains by ultra deep sequencing does not compromise response to maraviroc containing regimen [abstract no. 22]
    • Mar Sorrento
    • Garcia F, Chueca N, Alvarez M, et al. Low detection of non-CCR5 using strains by ultra deep sequencing does not compromise response to maraviroc containing regimen [abstract no. 22]. 8th European HIV Drug Resistance Workshop; 2010 Mar 17-19; Sorrento
    • (2010) 8th European HIV Drug Resistance Workshop , pp. 17-19
    • Garcia, F.1    Chueca, N.2    Alvarez, M.3
  • 34
    • 72949118928 scopus 로고    scopus 로고
    • CCR5-tropic resistance to maraviroc is uncommon even among patients on functional maraviroc monotherapy or with ongoing low-level replication [abstract no. 639]
    • Feb Montreal (QC)
    • Jubb B, Lewis M, Simpson P, et al. CCR5-tropic resistance to maraviroc is uncommon even among patients on functional maraviroc monotherapy or with ongoing low-level replication [abstract no. 639]. 16th Conference on Retroviruses and Opportunistic Infections; 2009 Feb 8-11; Montreal (QC)
    • (2009) 16th Conference on Retroviruses and Opportunistic Infections; , pp. 8-11
    • Jubb, B.1    Lewis, M.2    Simpson, P.3
  • 35
    • 77949401302 scopus 로고    scopus 로고
    • Are the proposed env mutations actually associated with resistance to mar-aviroc? [letter]
    • April 1
    • Saracino A, Monno L, Brindicci G, et al. Are the proposed env mutations actually associated with resistance to mar-aviroc? [letter]. J Acquir Immune Defic Syndr 2010 April 1; 53 (4): 550-552
    • (2010) J Acquir Immune Defic Syndr , vol.53 , Issue.4 , pp. 550-552
    • Saracino, A.1    Monno, L.2    Brindicci, G.3
  • 36
    • 77953090824 scopus 로고    scopus 로고
    • Mechanisms of virologic failure with maraviroc in treatment-naive HIV-infected patients through 96 weeks [abstract plus poster no. 536]
    • Feb San Francisco (CA)
    • Craig C, Heera J, Lewis M, et al. Mechanisms of virologic failure with maraviroc in treatment-naive HIV-infected patients through 96 weeks [abstract plus poster no. 536]. 17th Conference on Retroviruses and Opportunistic Infections; 2010 Feb 16-19; San Francisco (CA)
    • (2010) 17th Conference on Retroviruses and Opportunistic Infections , pp. 16-19
    • Craig, C.1    Heera, J.2    Lewis, M.3
  • 37
    • 77953112270 scopus 로고    scopus 로고
    • CXCR4-using virus detected in patients receiving maraviroc in the phase 3 studies MOTIVATE 1 and MOTIVATE 2 originates from a pre-existing minority of CXCR4-using virus [abstract no. 56 plus poster and oral presentation]
    • Jun Barbados
    • Lewis M, Simpson P, Fransen S, et al. CXCR4-using virus detected in patients receiving maraviroc in the phase 3 studies MOTIVATE 1 and MOTIVATE 2 originates from a pre-existing minority of CXCR4-using virus [abstract no. 56 plus poster and oral presentation]. XVI International HIV Drug Resistance Workshop; 2007 Jun 12-16; Barbados
    • (2007) XVI International HIV Drug Resistance Workshop; , pp. 12-16
    • Lewis, M.1    Simpson, P.2    Fransen, S.3
  • 38
    • 77953109463 scopus 로고    scopus 로고
    • Effect of CCR5 locus polymorphisms on virologic response to maraviroc in antiretroviral-experienced CCR5-tropic individuals in MOTIVATE 1 and 2 [abstract no. P4.4/04]
    • Oct Mtadrid
    • Sanders F, Wheeler JG, Myrand SP, et al. Effect of CCR5 locus polymorphisms on virologic response to maraviroc in antiretroviral-experienced CCR5-tropic individuals in MOTIVATE 1 and 2 [abstract no. P4.4/04]. 11th European AIDS Conference; 2007 Oct 24-27; Madrid, 51
    • (2007) 11th European AIDS Conference; , vol.51 , pp. 24-27
    • Sanders, F.1    Wheeler, J.G.2    Myrand, S.P.3
  • 39
    • 68449086889 scopus 로고    scopus 로고
    • Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women
    • Aug 15
    • Dumond JB, Patterson KB, Pecha AL, et al. Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women. J Acquir Immune Defic Syndr 2009 Aug 15; 51 (5): 546-553
    • (2009) J Acquir Immune Defic Syndr , vol.51 , Issue.5 , pp. 546-553
    • Dumond, J.B.1    Patterson, K.B.2    Pecha, A.L.3
  • 40
    • 79251529143 scopus 로고    scopus 로고
    • Maraviroc levels in cerebrospinal fluid (CSF) and seminal plasma from HIV-infected patients [abstract plus poster no. 114]
    • Feb San Francisco (CA)
    • Tiraboschi JM, Curto J, Niubo J, et al. Maraviroc levels in cerebrospinal fluid (CSF) and seminal plasma from HIV-infected patients [abstract plus poster no. 114]. 17th Conference on Retroviruses and Opportunistic Infections; 2010 Feb 16-19; San Francisco (CA)
    • (2010) 17th Conference on Retroviruses and Opportunistic Infections , pp. 16-19
    • Tiraboschi, J.M.1    Curto, J.2    Niubo, J.3
  • 41
    • 77953089918 scopus 로고    scopus 로고
    • Antiretrovirals for prevention: Maraviroc exposure in the semen and rectal tissue of healthy male volunteers after single and multiple dosing [abstract no. 85]
    • Feb San Francisco (CA)
    • Brown K, Patterson K, Malone S, et al. Antiretrovirals for prevention: maraviroc exposure in the semen and rectal tissue of healthy male volunteers after single and multiple dosing [abstract no. 85]. 17th Conference on Retroviruses and Opportunistic Infections; 2010 Feb 16-19; San Francisco (CA)
    • (2010) 17th Conference on Retroviruses and Opportunistic Infections , pp. 16-19
    • Brown, K.1    Patterson, K.2    Malone, S.3
  • 42
    • 72949113630 scopus 로고    scopus 로고
    • Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients
    • Nov 27
    • Yilmaz A, Watson V, Else L, et al. Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients. AIDS 2009 Nov 27; 23 (18): 2537-2540
    • (2009) AIDS , vol.23 , Issue.18 , pp. 2537-2540
    • Yilmaz, A.1    Watson, V.2    Else, L.3
  • 43
    • 51649088021 scopus 로고    scopus 로고
    • Maraviroc: In vitro assessment of drug-drug interaction potential
    • Oct
    • Hyland R, Dickins M, Collins C, et al. Maraviroc: in vitro assessment of drug-drug interaction potential. Br J Clin Pharmacol 2008 Oct; 66 (4): 498-507
    • (2008) Br J Clin Pharmacol , vol.66 , Issue.4 , pp. 498-507
    • Hyland, R.1    Dickins, M.2    Collins, C.3
  • 44
    • 40549124307 scopus 로고    scopus 로고
    • The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers
    • DOI 10.1111/j.1365-2125.2008.03135.x
    • Abel S, Russell D, Whitlock LA, et al. The effects of cotri-moxazole or tenofovir co-administration on the pharmaco-kinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008 Apr; 65 Suppl. 1: 47-53 (Pubitemid 351366538)
    • (2008) British Journal of Clinical Pharmacology , vol.65 , Issue.SUPPL. 1 , pp. 47-53
    • Abel, S.1    Russell, D.2    Whitlock, L.A.3    Ridgway, C.E.4    Muirhead, G.J.5
  • 45
    • 40549090550 scopus 로고    scopus 로고
    • Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers
    • DOI 10.1111/j.1365-2125.2008.03132.x
    • Abel S, Russell D, Whitlock LA, et al. Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/ levonorgestrel in healthy volunteers. Br J Clin Pharmacol 2008 Apr; 65 Suppl. 1: 19-26 (Pubitemid 351366535)
    • (2008) British Journal of Clinical Pharmacology , vol.65 , Issue.SUPPL. 1 , pp. 19-26
    • Abel, S.1    Russell, D.2    Whitlock, L.A.3    Ridgway, C.E.4    Muirhead, G.J.5
  • 46
    • 72949119327 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetics of co-administered maraviroc and ralte-gravir
    • Jan
    • Andrews E, Glue P, Fang J, et al. Assessment of the pharmacokinetics of co-administered maraviroc and ralte-gravir. Br J Clin Pharmacol 2010 Jan; 69 (1): 51-57
    • (2010) Br J Clin Pharmacol , vol.69 , Issue.1 , pp. 51-57
    • Andrews, E.1    Glue, P.2    Fang, J.3
  • 47
    • 40549086936 scopus 로고    scopus 로고
    • Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
    • DOI 10.1111/j.1365-2125.2008.03134.x
    • Abel S, Jenkins TM, Whitlock LA, et al. Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008 Apr; 65 Suppl. 1: 38-46 (Pubitemid 351366537)
    • (2008) British Journal of Clinical Pharmacology , vol.65 , Issue.SUPPL. 1 , pp. 38-46
    • Abel, S.1    Jenkins, T.M.2    Whitlock, L.A.3    Ridgway, C.E.4    Muirhead, G.J.5
  • 48
    • 40549127134 scopus 로고    scopus 로고
    • Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
    • Apr
    • Abel S, Russell D, Taylor-Worth RJ, et al. Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008 Apr; 65 Suppl. 1: 27-37
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.1 SUPPL. , pp. 27-37
    • Abel, S.1    Russell, D.2    Taylor-Worth, R.J.3
  • 49
    • 34249089383 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in vire-mic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results from a phase 2b/3 study in the US and Canada [abstract no. 104bLB plus oral presentation]
    • Feb Los Angeles (CA)
    • Lalezari J, Goodrich J, DeJesus E, et al. Efficacy and safety of maraviroc plus optimized background therapy in vire-mic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results from a phase 2b/3 study in the US and Canada [abstract no. 104bLB plus oral presentation]. 14th Conference on Retroviruses and Opportunistic Infections; 2007 Feb 25-28; Los Angeles (CA)
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections; , pp. 25-28
    • Lalezari, J.1    Goodrich, J.2    Dejesus, E.3
  • 50
    • 34249075565 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1 in Europe Australia and North America: 24-week results [abstract no. 104aLB plus oral presentation]
    • Feb Los Angeles (CA)
    • Nelson M, Fatkenheuer G, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia and North America: 24-week results [abstract no. 104aLB plus oral presentation]. 14th Conference on Retroviruses and Opportunistic Infections; 2007 Feb 25-28; Los Angeles (CA)
    • (2007) 14th Conference on Retroviruses and Opportunistic Infections , pp. 25-28
    • Nelson, M.1    Fatkenheuer, G.2    Konourina, I.3
  • 51
    • 77953107394 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc in treatment-experienced patients infected with R5 HIV-I: 96-week combined analysis of the MOTIVATE 1 and 2 studies [oral presentation plus abstract no. O425]
    • Nov Glasgow
    • Hardy WD, Gulick R, Mayer HB, et al. Efficacy and safety of maraviroc in treatment-experienced patients infected with R5 HIV-I: 96-week combined analysis of the MOTIVATE 1 and 2 studies [oral presentation plus abstract no. O425]. 9th International Congress on Drug Therapy in HIV Infection; 2008 Nov 9-13; Glasgow
    • (2008) 9th International Congress on Drug Therapy in HIV Infection; , pp. 9-13
    • Hardy, W.D.1    Gulick, R.2    Mayer, H.B.3
  • 53
    • 77953090090 scopus 로고    scopus 로고
    • Incidence of ma-lignancies in treatment-experienced (TE) patients in the MOTIVATE studies of maraviroc (MVC) +optimized background therapy (OBT): 96 week follow-up [abstract plus poster no. WEPEB246]
    • Jul Cape Town
    • Ayoub A, Walmsley R, Campo R, et al. Incidence of ma-lignancies in treatment-experienced (TE) patients in the MOTIVATE studies of maraviroc (MVC) +optimized background therapy (OBT): 96 week follow-up [abstract plus poster no. WEPEB246]. 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention; 2009 Jul 19-22; Cape Town
    • (2009) 5th IAS Conference on HIV Pathogenesis Treatment and Prevention; , pp. 19-22
    • Ayoub, A.1    Walmsley, R.2    Campo, R.3
  • 54
    • 54849146400 scopus 로고    scopus 로고
    • A new class of anti-HIV therapy and new chal-lenges
    • Oct 2
    • Dolin R. A new class of anti-HIV therapy and new chal-lenges. N Engl J Med 2008 Oct 2; 359 (14): 1509-1511
    • (2008) N Engl J Med , vol.359 , Issue.14 , pp. 1509-1511
    • Dolin, R.1
  • 55
    • 77952577892 scopus 로고    scopus 로고
    • Factors asso-ciated with proviral DNA HIV-1 tropism in antiretroviral therapy-treated patients with fully suppressed plasma HIV viral load: Implications for the clinical use of CCR5 antagonists
    • Apr
    • Soulie C, Fourati S, Lambert-Niclot S, et al. Factors asso-ciated with proviral DNA HIV-1 tropism in antiretroviral therapy-treated patients with fully suppressed plasma HIV viral load: implications for the clinical use of CCR5 antagonists. J Antimicrob Chemother 2010 Apr; 65 (4): 749-751
    • (2010) J Antimicrob Chemother , vol.65 , Issue.4 , pp. 749-751
    • Soulie, C.1    Fourati, S.2    Lambert-Niclot, S.3
  • 56
    • 58849097831 scopus 로고    scopus 로고
    • The relationship of CCR5 inhibitors to CD4 cell count changes: A meta-analysis of recent clinical trials in treatment-experienced subjects [abstract no. 800]
    • Feb Boston (MA)
    • Wilkin T, Ribaudo H, Gulick R. The relationship of CCR5 inhibitors to CD4 cell count changes: a meta-analysis of recent clinical trials in treatment-experienced subjects [abstract no. 800]. 15th Conference on Retroviruses and Opportunistic Infections; 2008 Feb 3-6; Boston (MA)
    • (2008) 15th Conference on Retroviruses and Opportunistic Infections; , pp. 3-6
    • Wilkin, T.1    Ribaudo, H.2    Gulick, R.3
  • 57
    • 67650694310 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of maraviroc in treatment-experienced patients infected with non-R5 HIV-1
    • Jun 1
    • Saag M, Goodrich J, Fatkenheuer G, et al. A double-blind, placebo-controlled trial of maraviroc in treatment-experienced patients infected with non-R5 HIV-1. J Infect Dis 2009 Jun 1; 199 (11): 1638-1647
    • (2009) J Infect Dis , vol.199 , Issue.11 , pp. 1638-1647
    • Saag, M.1    Goodrich, J.2    Fatkenheuer, G.3
  • 58
    • 33747859618 scopus 로고    scopus 로고
    • The cost of antiretroviral drugs and influence on prescribing policies
    • Jones R, Gazzard B. The cost of antiretroviral drugs and influence on prescribing policies. Int J STD AIDS 2006; 17: 499-506
    • (2006) Int J STD AIDS , vol.17 , pp. 499-506
    • Jones, R.1    Gazzard, B.2
  • 59
    • 77953084801 scopus 로고    scopus 로고
    • Modelling the cost-effectiveness of maraviroc for antiretroviral treatment-experienced individuals [abstract plus poster no. P10.4/02]
    • Oct Madrid
    • Kuehne FC, Chancellor J, Mollon P, et al. Modelling the cost-effectiveness of maraviroc for antiretroviral treatment-experienced individuals [abstract plus poster no. P10.4/02]. 11th European AIDS Conference; 2007 Oct 24-27; Madrid, 108
    • (2007) 11th European AIDS Conference; , vol.108 , pp. 24-27
    • Kuehne, F.C.1    Chancellor, J.2    Mollon, P.3
  • 60
    • 77953100912 scopus 로고    scopus 로고
    • A microsimulation of the cost-effectiveness of maraviroc for antiretroviral treatment-experienced HIV-infected individuals [abstract no. IN3]
    • May 30
    • Chancellor JV, Kuehne FC, Mollon P, et al. A microsimulation of the cost-effectiveness of maraviroc for antiretroviral treatment-experienced HIV-infected individuals [abstract no. IN3]. Value Health 2008 May 30; 11 (No.3): A24
    • (2008) Value Health , vol.11 , Issue.3
    • Chancellor, J.V.1    Kuehne, F.C.2    Mollon, P.3
  • 63
    • 77953101876 scopus 로고    scopus 로고
    • A cost-effectiveness analysis of maraviroc in treatment-experienced HIV patients in Scotland [abstract no. P315]
    • Nov Glasgow
    • Lekander I, Berg J, Christie A, et al. A cost-effectiveness analysis of maraviroc in treatment-experienced HIV patients in Scotland [abstract no. P315]. 9th International Congress on Drug Therapy in HIV Infection; 2008 Nov 9-13; Glasgow
    • (2008) 9th International Congress on Drug Therapy in HIV Infection; , pp. 9-13
    • Lekander, I.1    Berg, J.2    Christie, A.3
  • 64
    • 35048814879 scopus 로고    scopus 로고
    • Maraviroc: A viewpoint
    • Fatkenheuer G. Maraviroc: a viewpoint. Drugs 2007; 67: 2289-2290
    • (2007) Drugs , vol.67 , pp. 2289-2290
    • Fatkenheuer, G.1


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