Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation—An Increasingly Recognized Manifestation of Chronic Graft-versus-Host Disease

Biology of Blood and Marrow Transplantation

Volumn 16, Issue 1, 2010, Pages S106-S114

  Chien, Jason W ^a   Duncan, Steven ^b   Williams, Kirsten M ^c   Pavletic, Steven Z ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN;

ANIMAL; BRONCHIOLITIS OBLITERANS; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; HUMAN; IMMUNOLOGY; REVIEW;

ANIMALS; BRONCHIOLITIS OBLITERANS; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; ISOANTIGENS; TRANSPLANTATION IMMUNOLOGY;

MLCS; MLOWN;

EID: 77953071972     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2009.11.002     Document Type: Article

References (88)

1. Dudek, A.Z., Mahaseth, H., DeFor, T.E., Weisdorf, D.J., Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes. Biol Blood Marrow Transplant 9 (2003), 657–666.
2. Nicod, L.P., Mechanisms of airway obliteration after lung transplantation. Proc Am Thorac Soc 3 (2006), 444–449.
3. Filipovich, A.H., Weisdorf, D., Pavletic, S., et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 11 (2005), 945–956.
4. Santo Tomas, L.H., Loberiza, F.R. Jr., Klein, J.P., et al. Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia. Chest 128 (2005), 153–161.
5. Marras, T.K., Chan, C.K., Lipton, J.H., et al. Long-term pulmonary function abnormalities and survival after allogeneic marrow transplantation. Bone Marrow Transplant 33 (2004), 509–517.
6. Holland, H.K., Wingard, J.R., Beschorner, W.E., Saral, R., Santos, G.W., Bronchiolitis obliterans in bone marrow transplantation and its relationship to chronic graft-v-host disease and low serum IgG. Blood 72 (1988), 621–627.
7. Chien, J.W., Martin, P.J., Gooley, T.A., et al. Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation. Am J Respir Crit Care Med 168 (2003), 208–214.
8. Watkins, T.R., Chien, J.W., Crawford, S.W., Graft versus host-associated pulmonary disease and other idiopathic pulmonary complications after hematopoietic stem cell transplant. Semin Respir Crit Care Med 26 (2005), 482–489.
9. Yoshihara, S., Tateishi, U., Ando, T., et al. Lower incidence of bronchiolitis obliterans in allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning compared with myeloablative conditioning. Bone Marrow Transplant 35 (2005), 1195–1200.
10. Clark, J.G., Schwartz, D.A., Flournoy, N., et al. Risk factors for airflow obstruction in recipients of bone marrow transplants. Ann Intern Med 107 (1987), 648–656.
11. Chien, J.W., Madtes, D.K., Clark, J.G., Pulmonary function testing prior to hematopoietic stem cell transplantation. Bone Marrow Transplant 35 (2005), 429–435.
12. Curtis, D.J., Smale, A., Thien, F., Schwarer, A.P., Szer, J., Chronic airflow obstruction in long-term survivors of allogeneic bone marrow transplantation. Bone Marrow Transplant 16 (1995), 169–173.
13. Duncker, C., Dohr, D., Harsdorf, S., et al. Non-infectious lung complications are closely associated with chronic graft-versus-host disease: a single center study of incidence, risk factors and outcome. Bone Marrow Transplant 25 (2000), 1263–1268.
14. Schwarer, A.P., Hughes, J.M., Trotman-Dickenson, B., Krausz, T., Goldman, J.M., A chronic pulmonary syndrome associated with graft-versus-host disease after allogeneic marrow transplantation. Transplantation 54 (1992), 1002–1008.
15. Beinert, T., Dull, T., Wolf, K., et al. Late pulmonary impairment following allogeneic bone marrow transplantation. Eur J Med Res 1 (1996), 343–348.
16. Tait, R.C., Burnett, A.K., Robertson, A.G., et al. Subclinical pulmonary function defects following autologous and allogeneic bone marrow transplantation: relationship to total body irradiation and graft-versus-host disease. Int J Radiat Oncol Biol Phys 20 (1991), 1219–1227.
17. Erard, V., Chien, J.W., Kim, H.W., et al. Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses. J Infect Dis 193 (2006), 1619–1625.
18. Stein-Streilein, J., Lipscomb, M.F., Hart, D.A., Darden, A., Graft-versus-host reaction in the lung. Transplantation 32 (1981), 38–44.
19. Epler, G.R., Colby, T.V., The spectrum of bronchiolitis obliterans. Chest 83 (1983), 161–162.
20. Belperio, J.A., Keane, M.P., Burdick, M.D., et al. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J Clin Invest 108 (2001), 547–556.
21. Aris, R.M., Walsh, S., Chalermskulrat, W., Hathwar, V., Neuringer, I.P., Growth factor upregulation during obliterative bronchiolitis in the mouse model. Am J Respir Crit Care Med 166 (2002), 417–422.
22. Boehler, A., Bai, X.H., Liu, M., et al. Upregulation of T-helper 1 cytokines and chemokine expression in post-transplant airway obliteration. Am J Respir Crit Care Med 159 (1999), 1910–1917.
23. Boehler, A., Chamberlain, D., Kesten, S., et al. Lymphocytic airway infiltration as a precursor to fibrous obliteration in a rat model of bronchiolitis obliterans. Transplantation 64 (1997), 311–317.
24. Neuringer, I.P., Chalermskulrat, W., Aris, R., Obliterative bronchiolitis or chronic lung allograft rejection: a basic science review. J Heart Lung Transplant 24 (2005), 3–19.
25. Michel, O., Kips, J., Duchateau, J., et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 154 (1996), 1641–1646.
26. Michel, O., Ginanni, R., Duchateau, J., et al. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 21 (1991), 441–448.
27. Kline, J.N., Cowden, J.D., Hunninghake, G.W., et al. Variable airway responsiveness to inhaled lipopolysaccharide. Am J Respir Crit Care Med 160 (1999), 297–303.
28. Savov, J.D., Brass, D.M., Lawson, B.L., et al. Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide. Am J Physiol Lung Cell Mol Physiol 289 (2005), L329–L337.
29. Chien, J.W., Zhao, L.P., Hansen, J.A., et al. Genetic variation in bactericidal/permeability-increasing protein influences the risk of developing rapid airflow decline after hematopoietic cell transplantation. Blood 107 (2006), 2200–2207.
30. Hildebrandt, G.C., Granell, M., Urbano-Ispizua, A., et al. Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. Biol Blood Marrow Transplant 14 (2008), 67–74.
31. Palmer, S.M., Klimecki, W., Yu, L., et al. Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14. Am J Transplant 7 (2007), 693–699.
32. Chalermskulrat, W., Neuringer, I.P., Brickey, W.J., et al. Hierarchical contributions of allorecognition pathways in chronic lung rejection. Am J Respir Crit Care Med 167 (2003), 999–1007.
33. Richards, D.M., Dalheimer, S.L., Ehst, B.D., et al. Indirect minor histocompatibility antigen presentation by allograft recipient cells in the draining lymph node leads to the activation and clonal expansion of CD4 + T cells that cause obliterative airways disease. J Immunol 172 (2004), 3469–3479.
34. Duncan, S.R., Capetanakis, N.G., Lawson, B.R., Theofilopoulos, A.N., Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival. J Clin Invest 109 (2002), 755–764.
35. Kelly, K.E., Hertz, M.I., Mueller, D.L., T-cell and major histocompatibility complex requirements for obliterative airway disease in heterotopically transplanted murine tracheas. Transplantation 66 (1998), 764–771.
36. Neuringer, I.P., Mannon, R.B., Coffman, T.M., et al. Immune cells in a mouse airway model of obliterative bronchiolitis. Am J Respir Cell Mol Biol 19 (1998), 379–386.
37. Sakaida, E., Nakaseko, C., Harima, A., et al. Late-onset noninfectious pulmonary complications after allogeneic stem cell transplantation are significantly associated with chronic graft-versus-host disease and with the graft-versus-leukemia effect. Blood 102 (2003), 4236–4242.
38. Trulock, E.P., Christie, J.D., Edwards, L.B., et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult lung and heart-lung transplantation report—2007. J Heart Lung Transplant 26 (2007), 782–795.
39. Estenne, M., Hertz, M.I., Bronchiolitis obliterans after human lung transplantation. Am J Respir Crit Care Med 166 (2002), 440–444.
40. Knoop, C., Estenne, M., Acute and chronic rejection after lung transplantation. Semin Respir Crit Care Med 27 (2006), 521–533.
41. Hopkins, P.M., Aboyoun, C.L., Chhajed, P.N., et al. Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis. Am J Respir Crit Care Med 170 (2004), 1022–1026.
42. Verleden, G.M., Dupont, L.J., Van Raemdonck, D.E., Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal?. Eur Respir J 25 (2005), 221–224.
43. Girnita, A.L., Duquesnoy, R., Yousem, S.A., et al. HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunction. Am J Transplant 5 (2005), 131–138.
44. Daud, S.A., Yusen, R.D., Meyers, B.F., et al. Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 175 (2007), 507–513.
45. Duncan, S.R., Paradis, I.L., Yousem, S.A., et al. Sequelae of cytomegalovirus pulmonary infections in lung allograft recipients. Am Rev Respir Dis 146 (1992), 1419–1425.
46. Gao, L.H., Zheng, S.S., Cytomegalovirus and chronic allograft rejection in liver transplantation. World J Gastroenterol 10 (2004), 1857–1861.
47. Kostareli, E., Hadzidimitriou, A., Stavroyianni, N., et al. Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Leukemia 23 (2009), 919–924.
48. Duncan, S.R., Cook, D.J., Survival of ganciclovir-treated heart transplant recipients with cytomegalovirus pneumonitis. Transplantation 52 (1991), 910–913.
49. Krensky, A.M., Weiss, A., Crabtree, G., Davis, M.M., Parham, P., T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med 322 (1990), 510–517.
50. Ely, L.K., Burrows, S.R., Purcell, A.W., Rossjohn, J., McCluskey, J., T-cells behaving badly: structural insights into alloreactivity and autoimmunity. Curr Opin Immunol 20 (2008), 575–580.
51. Duncan, S.R., Valentine, V., Roglic, M., et al. T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitis. J Clin Invest 97 (1996), 2642–2650.
52. Duncan, S.R., Leonard, C., Theodore, J., et al. Oligoclonal CD4(+) T cell expansions in lung transplant recipients with obliterative bronchiolitis. Am J Respir Crit Care Med 165 (2002), 1439–1444.
53. Kuo, E., Bharat, A., Dharmarajan, S., et al. Animal models for bronchiolitis obliterans syndrome following human lung transplantation. Immunol Res 33 (2005), 69–81.
54. George, M.P., Zhu, X., Stoner, M.W., Myerburg, M., Duncan, S.R., A human-murine chimeric model of lung transplantation. Proc Am Thorac Soc, 2006, A538.
55. Stewart, S., Fishbein, M.C., Snell, G.I., et al. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J Heart Lung Transplant 26 (2007), 1229–1242.
56. Estenne, M., Maurer, J.R., Boehler, A., et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant 21 (2002), 297–310.
57. Studer, S.M., George, M.P., Zhu, X., et al. CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipients. Am J Respir Crit Care Med 178 (2008), 765–773.
58. Vallejo, A.N., Weyand, C.M., Goronzy, J.J., T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol. Med 10 (2004), 119–124.
59. Gadgil, A.S., Zhu, Z., Stoner, M.W., Duncan, S.R., Allograft tolerance conferred by adoptive transfer of splenic dendritic cells. Proc Am Thorac Soc, 2005, A859.
60. Clark, J.G., Crawford, S.W., Madtes, D.K., Sullivan, K.M., Obstructive lung disease after allogeneic marrow transplantation. Clinical presentation and course. Ann Intern Med 111 (1989), 368–376.
61. White, D.A., Wong, P.W., Downey, R., The utility of open lung biopsy in patients with hematologic malignancies. Am J Respir Crit Care Med 161 (2000), 723–729.
62. Suzuki, T., Saijo, Y., Ebina, M., et al. Bilateral pneumothoraces with multiple bullae in a patient with asymptomatic bronchiolitis obliterans 10 years after bone marrow transplantation. Bone Marrow Transplant 23 (1999), 829–831.
63. Chadwick, C., Marven, S.M., Vora, A.J., Autologous blood pleurodesis for pneumothorax complicating graft-versus-host disease-related bronchiolitis obliterans. Bone Marrow Transplant 33 (2004), 451–453.
64. Kumar, S., Tefferi, A., Spontaneous pneumomediastinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic bone marrow transplantation—case report and review of literature. Ann Hematol 80 (2001), 430–435.
65. Vogelsang, G.B., Lee, L., Bensen-Kennedy, D.M., Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant. Annu Rev Med 54 (2003), 29–52.
66. Yokoi, T., Hirabayashi, N., Ito, M., et al. Broncho-bronchiolitis obliterans as a complication of bone marrow transplantation: a clinicopathological study of eight autopsy cases. Nagoya BMT Group. Virchows Arch 431 (1997), 275–282.
67. Diez Herranz, A., RV/TLC% ratio: alternative criteria of normality. Eur Respir J 8 (1995), 1812–1813.
68. Guttadauria, M., Ellman, H., Emmanuel, G., Kaplan, D., Diamond, H., Pulmonary function in scleroderma. Arthritis Rheum 20 (1977), 1071–1079.
69. Gunn, M.L., Godwin, J.D., Kanne, J.P., Flowers, M.E., Chien, J.W., High-resolution CT findings of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. J Thorac Imaging 23 (2008), 244–250.
70. Williams, K.M., Chien, J.W., Gladwin, M.T., Pavletic, S.Z., Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. JAMA 302 (2009), 306–314.
71. Clark, J.G., The challenge of bone marrow transplantation. Mayo Clin Proc 65 (1990), 111–114.
72. Chan, C.K., Hyland, R.H., Hutcheon, M.A., et al. Small-airways disease in recipients of allogeneic bone marrow transplants. An analysis of 11 cases and a review of the literature. Medicine (Baltimore) 66 (1987), 327–340.
73. Hollmen, M., Tikkanen, J.M., Nykanen, A.I., Koskinen, P.K., Lemstrom, K.B., Tacrolimus treatment effectively inhibits progression of obliterative airway disease even at later stages of disease development. J Heart Lung Transplant 27 (2008), 856–864.
74. Snell, G.I., Esmore, D.S., Williams, T.J., Cytolytic therapy for the bronchiolitis obliterans syndrome complicating lung transplantation. Chest 109 (1996), 874–878.
75. Fullmer, J.J., Fan, L.L., Dishop, M.K., Rodgers, C., Krance, R., Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade. Pediatrics 116 (2005), 767–770.
76. Ratjen, F., Rjabko, O., Kremens, B., High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children. Bone Marrow Transplant 36 (2005), 135–138.
77. Duncan, C.N., Buonanno, M.R., Barry, E.V., et al. Bronchiolitis obliterans following pediatric allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 41 (2008), 971–975.
78. Khalid, M., Al Saghir, A., Saleemi, S., et al. Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study. Eur Respir J 25 (2005), 490–493.
79. Bashoura, L., Gupta, S., Jain, A., et al. Inhaled corticosteroids stabilize constrictive bronchiolitis after hematopoietic stem cell transplantation. Bone Marrow Transplant 41 (2008), 63–67.
80. Smith, E.P., Sniecinski, I., Dagis, A.C., et al. Extracorporeal photochemotherapy for treatment of drug-resistant graft-vs.-host disease. Biol Blood Marrow Transplant 4 (1998), 27–37.
81. Besnier, D.P., Chabannes, D., Mahe, B., et al. Treatment of graft-versus-host disease by extracorporeal photochemotherapy: a pilot study. Transplantation 64 (1997), 49–54.
82. Ilhan, O., Arat, M., Arslan, O., et al. Extracorporeal photoimmunotherapy for the treatment of steroid refractory progressive chronic graft-versus-host disease. Transfus Apher Sci 30 (2004), 185–187.
83. Majhail, N.S., Schiffer, C.A., Weisdorf, D.J., Improvement of pulmonary function with imatinib mesylate in bronchiolitis obliterans following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 12 (2006), 789–791.
84. Johnson, B.A., Iacono, A.T., Zeevi, A., McCurry, K.R., Duncan, S.R., Statin use is associated with improved function and survival of lung allografts. Am J Respir Crit Care Med 167 (2003), 1271–1278.
85. Or, R., Gesundheit, B., Resnick, I., et al. Sparing effect by montelukast treatment for chronic graft versus host disease: a pilot study. Transplantation 83 (2007), 577–581.
86. Islam, S.A., Thomas, S.Y., Hess, C., et al. The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans. Blood 107 (2006), 444–453.
87. Wilborn, J., Bailie, M., Coffey, M., et al. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest 97 (1996), 1827–1836.
88. Medoff, B.D., Seung, E., Wain, J.C., et al. BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. J Exp Med 202 (2005), 97–110.