Novel isosteric charge-deficient spermine analogue-1,12-diamino-3,6,9- triazadodecane: Synthesis, pKa measurement and biological activity

Amino Acids

Volumn 38, Issue 2, 2010, Pages 501-507

  Weisell, Janne ^a   Hyvönen, Mervi T ^a   Vepsäläinen, Jouko ^a   Alhonen, Leena ^a   Keinänen, Tuomo A ^a   Khomutov, Alex R ^b   Soininen, Pasi ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

Cell growth; NMR spectroscopy; pKa; Polyamines; Spermine analogues

Indexed keywords

1,12 DIAMINO 3,6,9 TRIAZADODECANE; ADENOSYLMETHIONINE DECARBOXYLASE; EFLORNITHINE; ORNITHINE DECARBOXYLASE; SPERMINE; SPERMINE DERIVATIVE; TRIENTINE; UNCLASSIFIED DRUG; 1,12-DIAMINO-3,6,9-TRIAZADODECANE; CARBOXYLYASE; DRUG DERIVATIVE; METHIONINE DECARBOXYLASE; POLYAMINE;

BIOLOGICAL ACTIVITY; CARCINOMA CELL; CELL GROWTH; CELL LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; FEASIBILITY STUDY; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; MOLECULAR INTERACTION; NITROGEN NUCLEAR MAGNETIC RESONANCE; PH MEASUREMENT; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; ARTICLE; CELL PROLIFERATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; KINETICS; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

MAMMALIA;

CARBOXY-LYASES; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; KINETICS; ORNITHINE DECARBOXYLASE; POLYAMINES; SPERMINE;

EID: 77953046262     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0409-6     Document Type: Conference Paper

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