Effects of capsaicin-induced sensory denervation on bone metabolism in adult rats

Bone

Volumn 46, Issue 6, 2010, Pages 1591-1596

  Ding, Yuxiang ^a,b   Arai, Michitsugu ^a   Kondo, Hisataka ^a   Togari, Akifumi ^a  

^a AICHI GAKUIN UNIVERSITY   (Japan)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Biomechanical property; Bone metabolism; Capsaicin; Denervation; Sensory nerve

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME 5B; CAPSAICIN; OSTEOCALCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOMECHANICS; BONE DUCTILITY; BONE FRAGILITY; BONE GROWTH; BONE MASS; BONE METABOLISM; BONE REMODELING; BONE STRENGTH; BONE TOUGHNESS; CONTROLLED STUDY; DENERVATION; ELASTICITY; LUMBAR VERTEBRA; MALE; MORPHOMETRICS; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PHYSICAL PARAMETERS; PROTEIN BLOOD LEVEL; RAT; SENSORY NERVE; TRABECULAR BONE;

ACID PHOSPHATASE; ANIMALS; BIOMECHANICS; BODY WEIGHT; BONE AND BONES; CAPSAICIN; FEMUR; ISOENZYMES; LUMBAR VERTEBRAE; MALE; OSTEOCALCIN; RATS; RATS, WISTAR; SENSORY SYSTEM AGENTS; TIBIA;

EID: 77953026832     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.02.022     Document Type: Article

References (32)

1. Togari A., Arai M., Mizutani S., Mizutani S., Koshihara Y., Nagatsu T. Expression of mRNAs for neuropeptide receptors and β-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells. Neurosci Lett 1997, 233:125-128.
2. Togari A., Mogi M., Arai M., Yamamoto S., Koshihara Y. Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts. Brain Res 2000, 878:204-209.
3. Togari A. Adrenergic regulation of bone metabolism: possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells. Microsc Res Tech 2002, 58:77-84.
4. Takeda S., Elefteriou F., Levasseur R., Liu X., Zhao L., Parker K.L., Armstrong D., Ducy P., Karsenty G. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002, 111:305-317.
5. Togari A., Arai M., Kondo A. The role of the sympathetic nervous system in controlling bone metabolism. Expert Opin Ther Targets 2005, 9:931-940.
6. Togari A., Arai M. Pharmacological topics of bone metabolism: the physiological function of the sympathetic nervous system in modulating bone resorption. J Pharmacol Sci 2008, 106:542-546.
7. Hill E.L., Elde R. Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat. Cell Tissue Res 1991, 264:469-480.
8. Ishizuka K., Hirukawa K., Nakamura H., Togari A. Inhibitory effect of CGRP on osteoclast formation by mouse bone marrow cells treated with isoproterenol. Neurosci Lett 2005, 379:47-51.
9. Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., Julius D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 1997, 389:816-824.
10. Caterina M.J., Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 2001, 24:487-517.
11. Nagy J.I., Iversen L.L., Goedert M., Chapman D., Hunt S.P. Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J Neurosci 1983, 3:399-406.
12. Buck S.H., Burks T.F. The neuropharmacology of capsaicin: Review of some recent observations. Pharmacol Rev 1986, 38:179-226.
13. Virus R.M., McManus D.Q., Gebhart G.F. Capsaicin treatment in adult Wistar-Kyoto and spontaneously hypertensive rats: Effects on substance P contents of peripheral and central nervous system tissues. Eur J Pharmacol 1982, 81:67-73.
14. Hill E.L., Turner R., Elde R. Effects of neonatal sympathectomy and capsaicin treatment on bone remodeling in rats. Neuroscience 1991, 44:747-755.
15. Adam C., Llorens A., Baroukh B., Cherruau M., Saffar J.L. Effects of capsaicin-induced sensory denervation on osteoclastic resorption in adult rats. Exp Physiol 2000, 85:61-66.
16. Offley S.C., Guo T.Z., Wei T., Clark J.D., Vogel H., Lindsey D.P., Jacobs C.R., Yao W., Lane N.E., Kingery W.S. Capsaicin-sensitive sensory neurons contribute to the caintenance of trabecular bone integrity. J Bone Miner Res 2005, 20:257-267.
17. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., Ott S.M., Recker R.R. Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
18. Ali K.Z., Dickson G.R. Influence of the fibula on growth of the rat tibia. J Anat 1994, 184:347-353.
19. Holzer P. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 1991, 43:143-201.
20. Bjurholm A., Kreicbergs A., Brodin E., Schultzberg M. Substance P and CGRP-immunoreactive nerves in bone. Peptides 1988, 9:165-171.
21. Hara I.F., Amizuka N., Ozawa H. Immunohistochemical and ultrastructural localization of CGRP-positive nerve fibers at the epiphyseal trabecules facing the growth plate of rat femurs. Bone 1996, 18:29-39.
22. Imai S., Matsusue Y. Neural regulation of bone metabolism and anabolism: Calcitonin gene-related peptide-, substance P-, and tyrosine hydroxylase-containing nerves and bone. Microsc Res Tech 2002, 58:61-69.
23. Zaidi M., Fuller K., Bevis P.J., GainesDas R.E., Chambers T.J., MacIntyre I. Calcitonin gene-related peptide inhibits osteoclastic bone resorption: a comparative study. Calcif Tissue Int 1987, 40:149-154.
24. Valentijn K., Gutow A.P., Troiano N., Gundberg C., Gilligan J.P., Vignery A. Effects of calcitonin gene-related peptide on bone turnover in ovariectomized rats. Bone 1997, 21:269-274.
25. Sohn S.J. Substance P upregulates osteoclastogenesis by activating nuclear factor kappa B in osteoclast precursors. Acta Otolaryngol 2005, 125:130-133.
26. Matayoshi T., Goto T., Fukuhara E., Takano H., Kobayashi S., Takahashi T. Neuropeptide substance P stimulates the formation of osteoclasts via synovial fibroblastic cells. Biochem Biophys Res Commun 2005, 327:756-764.
27. Azuma H., Kido J., Ikedo D., Kataoka M., Nagata T. Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Porphyromonas gingivalis. J Periodontol 2004, 75:974-981.
28. Adamus M.A., Dabrowski Z.J. Effect of the neuropeptide substance P on the rat bone marrow-derived osteogenic cells in vitro. J Cell Biochem 2001, 81:499-506.
29. Goto T., Nakao K., Gunjigake K.K., Kido M.A., Kobayashi S., Tanaka T. Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors. Neuropeptides 2007, 41:25-31.
30. Lerner U.H., Persson E. Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Musculoskelet Neuronal Interact 2008, 8:154-165.
31. Hukkanen M., Konttinen Y.T., Santavirta S., Paavolainen P., Gu X.H., Terenghi G., Polak J.M. Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling. Neuroscience 1993, 54:969-979.
32. Rameshwar P., Ganea D., Gascon P. In vitro stimulatory effect of substance P on hematopoiesis. Blood 1993, 81:391-398.