Effect of gabapentin on pain after cardiac surgery: A randomised, double-blind, placebo-controlled trial

Anaesthesia and Intensive Care

Volumn 38, Issue 3, 2010, Pages 445-451

  Rapchuk, I L ^a   O'Connell, L ^a   Liessmann, C D ^a   Cornelissen, H R ^a   Fraser, J F ^a  

^a THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

Cardiac surgery; Gabapentin; Postoperative analgesia

Indexed keywords

ANTIEMETIC AGENT; DIAZEPAM; FENTANYL; GABAPENTIN; ISOFLURANE; MAGNESIUM; METOCLOPRAMIDE; MIDAZOLAM; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PARACETAMOL; PETHIDINE; PLACEBO; PROPOFOL; RANITIDINE; SCOPOLAMINE; SEVOFLURANE; TEMAZEPAM; THIOPENTAL; TRAMADOL;

ADULT; ARTICLE; BODY MOVEMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG USE; EVENING DOSAGE; FEMALE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART SURGERY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; PAIN ASSESSMENT; PERIOPERATIVE PERIOD; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL; SEDATION; SHIVERING; SIDE EFFECT; SLEEP PATTERN;

EID: 77952969459     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x1003800306     Document Type: Article

References (27)

1. Lahtinen P, kokki H, Hynynen M. Pain after cardiac surgery: a prospective cohort study of 1-year incidence and intensity. Anesthesiology 2006; 105:794-800.
2. Alston RP, Pechon P. Dysaesthesia associated with sternotomy for heart surgery. Br J Anaesth 2005; 95:153-158.
3. Milgrom LB, Brooks JA, Qi R, Bunnell K, Wuestfeld S, Beckman D. Pain levels experienced with activities after cardiac surgery. Am J Crit Care 2004; 13:116-125. (Pubitemid 39456751)
4. Lynch EP, Lazor MA, Gellis JE, Orav J, Goldman L, Marcantonio ER. Patient experience of pain after elective noncardiac surgery. Anesth Analg 1997; 85:117-123. (Pubitemid 27342286)
5. Mueller XM, Tinguely F, Tevaearai HT, Revelly JP, Chiolero R, von Segesser LK. Pain location, distribution, and intensity after cardiac surgery. Chest 2000; 118:391-396. (Pubitemid 30637805)
6. Chaney MA. How important is postoperative pain after cardiac surgery? J Cardiothorac Vasc Anesth 2005; 19:705-707.
7. Eisenberg E, Pultorak Y, Pud D, Bar-El Y. Prevalence and characteristics of post coronary artery bypass graft surgery pain (PCP). Pain 2001; 92:11-17. (Pubitemid 32367932)
8. Ott E, Nussmeier NA, Duke PC, Feneck RO, Alston RP, Snabes MC et al. Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery. J Thorac Cardiovasc Surg 2003; 125:1481-1492. (Pubitemid 36759251)
9. Nussmeier NA, Whelton AA, Brown MT, Langford RM, Hoeft A, Parlow JL et al. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 2005; 352:1081-1091. (Pubitemid 40365349)
10. Magnano D, Montalbano R, Lamarra M, Ferri F, Lorini L, Clarizia S. Ineffectiveness of local wound anesthesia to reduce postoperative pain after median sternotomy. J Card Surg 2005; 20:314-318.
11. Hansdottir V, Philip J, Olsen MF, Eduard C, Houltz E, Ricksten S-E. Thoracic epidural versus intravenous patient-controlled analgesia after cardiac surgery: a randomized controlled trial on length of hospital stay and patient-perceived quality of recovery. Anesthesiology 2006; 104:142-151.
12. Mathiesen O, Moiniche S, Dahl JB. Gabapentin and postoperative pain: a qualitative and quantitative systematic review, with focus on procedure. BMC Anesthesiol 2007; 7:6.
13. Kong VKF, Irwin MG. Gabapentin: a multimodal perioperative drug? Br J Anaesth 2007; 99:775-786.
14. Tiippana EM, Hamunen K, kontinen VK, kalso E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg 2007; 104:1545-1556.
15. Hurley RW, Cohen SP, Williams KA, Rowlingson AJ, Wu CL. The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis. Reg Anesth Pain Med 2006; 31:237-247.
16. Ho K-Y, Gan TJ, Habib AS. Gabapentin and postoperative pain-a systematic review of randomized controlled trials. Pain 2006; 126:91-101.
17. Seib RK, Paul JE. Preoperative gabapentin for postoperative analgesia: a meta-analysis. Can J Anaesth 2006; 53:461-469.
18. Huot M-P, Chouinard P, Girard F, Ruel M, Lafontaine ER, Ferraro P. Gabapentin does not reduce post-thoracotomy shoulder pain: a randomized, double-blind placebo-controlled study. Can J Anaesth 2008; 55:337-343.
19. Myles PS, Hunt JO, Nightingale CE, Fletcher H, Beh T, Tanil D et al. Development and psychometric testing of a quality of recovery score after general anesthesia and surgery in adults. Anesth Analg 1999; 88:83-90. (Pubitemid 29025152)
20. McCartney CJL, Sinha A, katz J. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesth Analg 2004; 98:1385-1400.
21. Begon S, Pickering G, Eschalier A, Dubray C. Magnesium increases morphine analgesic effect in different experimental models of pain. Anesthesiology 2002; 96:627-632. (Pubitemid 34193503)
22. Prabhakar H, Arora R, Bithal PK, Rath GP, Dash HH. The analgesic effects of preemptive gabapentin in patients undergoing surgery for brachial plexus injury-a preliminary study. J Neurosurg Anesthesiol 2007; 19:235-238. (Pubitemid 47480714)
23. Mikkelsen S, Hilsted KL, Andersen PJ, Hjortso N-C, Enggaard TP, Jorgensen DG et al. The effect of gabapentin on post-operative pain following tonsillectomy in adults. Acta Anaesthesiol Scand 2006; 50:809-815. (Pubitemid 44034231)
24. Al-Mujadi H, A-Refai AR, katzarov MG, Dehrab NA, Batra YK, Al-Qattan AR. Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery. Can J Anaesth 2006; 53:268-273.
25. Fassoulaki A, Stamatakis E, Petropoulos G, Siafaka I, Hassiakos D, Sarantopoulos C. Gabapentin attenuates late but not acute pain after abdominal hysterectomy. Eur J Anaesthesiol 2006; 23:136-141. (Pubitemid 43144222)
26. Pandey CK, Navkar DV, Giri PJ, Raza M, Behari S, Singh RB et al. Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. J Neurosurg Anesthesiol 2005; 17:65-68.
27. Van Elstraete AC, Tirault M, Lebrun T, Sandefo I, Bernard J-C, Polin B et al. The median effective dose of preemptive gabapentin on postoperative morphine consumption after posterior lumbar spinal fusion. Anesth Analg 2008; 106:305-308.